MPD: Data set: McMullan3

McMullan3: Body composition responses following voluntary exercise in aging females of 43 Collaborative Cross strains of mice (2017)

McMullan RC, Pomp D, Pardo-Manuel de Villena F

McMullan3 downloads
• Download McMullan3 project data set animal data, as uploaded
• Download McMullan3 animal data matrix with factor-related expansion applied as necessary
• Download McMullan3 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to McMullan3 measures:

MA:0000009 adipose tissue
MP:0003959 abnormal lean body mass
MP:0005449 abnormal food intake
MP:0005457 abnormal percent body fat/body weight
MP:0012321 abnormal total tissue mass
VT:0001259 body mass
VT:0001431 eating behavior trait
VT:0005452 adipose amount
VT:0010482 body fat mass
VT:0010483 body lean mass

Investigators	Rachel C McMullan University of North Carolina, Chapel Hill, NC Daniel Pomp University of North Carolina, Chapel Hill, NC Fernando Pardo-Manuel de Villena University of North Carolina, Chapel Hill, NC
Contact	Fernando Pardo-Manuel de Villena fernando@med.unc.edu Lab web site
Part of a series:	• amount of voluntary exercise see McMullan2 • body composition after exercise (this project) McMullan3
Acknowledgements	Funding provided by NIH MH100241. Acknowledgements: Kunjie Hua and the Animal Metabolism & Phenotyping Core in NORC (Nutrition Obesity Research Center) University of North Carolina – Chapel Hill (DK05350). System Genetics Core and UNC U19 Project (NIH 1U19Al100625-01) for providing retired breeders.
Project type	Phenotype strain survey data set
MPD identifiers	McMullan3 MPD:606
Data changelog	No updates/corrections. Initial release date: 02/2018.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Female mice (n =186) from 43 CC strains were obtained from other experiments or from the System Genetics Core at UNC-Chapel Hill. The female mice in the experiment were all retired breeders and varied in life history and age. Mice had voluntary access to running wheels for 4 weeks. Body composition measures were taken before access to running wheels, after 2 weeks of exercise, and after 4 weeks of exercise.

Procedures conducted:

• body weight		Body weight before, during, and after several weeks of exercise.
• MRI		Body composition (fat and lean mass) before, during, and after several weeks of exercise.
• intake monitoring		Food intake, before, during, and after several weeks of exercise.

Mice: CC 43 strains ♀ age 20-88wks 1 experimental group

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
McMullan3:1	McMullan3	colony observation	(none)	age (local parameter) [mo] age_mo 60601	CC	43	f	20-88wks	N=4

McMullan3:11	McMullan3	body weight	(none)	body weight [g] body_wt 60611 start 2 wks 4 wks	CC	43	f	20-88wks	N=4

McMullan3:21	McMullan3	MRI	(none)	percentage of body mass that is fat [%] fat 60621 start 2 wks 4 wks	CC	43	f	20-88wks	N=4

McMullan3:31	McMullan3	MRI	(none)	percentage of body mass that is lean [%] lean 60631 start 2 wks 4 wks	CC	43	f	20-88wks	N=4

McMullan3:41	McMullan3	body weight	(none)	body weight response [%] body_wt_start 60641 start to 2 wks 2 wks to 4 wks start to 4 wks	CC	43	f	20-88wks	N=4

McMullan3:51	McMullan3	MRI	(none)	fat mass response [%] fat_start 60651 start to 2 wks 2 wks to 4 wks start to 4 wks	CC	43	f	20-88wks	N=4

McMullan3:61	McMullan3	MRI	(none)	lean mass response [%] lean_start 60661 start to 2 wks 2 wks to 4 wks start to 4 wks	CC	43	f	20-88wks	N=4

McMullan3:71	McMullan3	intake monitoring	(none)	food intake [g] food_start 60671 start to 2 wks 2 wks to 4 wks	CC	43	f	20-88wks	N=4