MPD: Data set: Leiter2

Leiter2: NOD x 129.H2g7 backcross delineates 129S1/SvImJ-derived genomic regions modulating type 1 diabetes development in mice (2009)

Leiter EH, Reifsnyder PC, Wallace R, Li R, King B, Churchill GC. NOD x 129.H2(g7) backcross delineates 129S1/SvImJ-derived genomic regions modulating type 1 diabetes development in mice. Diabetes. 2009 Jul;58(7):1700-3. Epub 2009 Mar 31. PubMed 19336673 FullText

A backcross of NOD × (NOD × 129.H2g7) was generated to identify 129S1/SvJ non-MHC regions contributing to type 1 diabetes development. A genome scan for QTLs affecting clinical diabetes, age of diabetes onset, and insulitis severity was performed for detection of diabetes susceptibility loci in 310 female mice from this cross. For detailed information see Leiter et al 2009.

Note on studied population: NOD x 129.H2g7 backcross.

Procedures conducted:

• study archive

Type 1 diabetes development study.

Leiter2 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.

Ontology terms mapped to Leiter2 measures:

MA:0002501 plasma
MP:0000180 abnormal circulating cholesterol level
MP:0000184 abnormal circulating HDL cholesterol level
MP:0000188 abnormal circulating glucose level
MP:0001259 abnormal body weight
MP:0001553 abnormal circulating free fatty acids level
MP:0001560 abnormal circulating insulin level
MP:0003959 abnormal lean body mass
MP:0005457 abnormal percent body fat/body weight
MP:0005667 abnormal circulating leptin level
MP:0010119 abnormal bone mineral density
MP:0010122 abnormal bone mineral content
MP:0011969 abnormal circulating triglyceride level
MP:0012320 abnormal body fat mass
MP:0012321 abnormal total tissue mass
MP:0020086 abnormal susceptibility to non-insulin-dependent diabetes
VT:0000180 blood cholesterol amount
VT:0000184 blood HDL cholesterol amount
VT:0000188 blood glucose amount
VT:0001259 body mass
VT:0001553 blood free fatty acid amount
VT:0001560 blood insulin amount
VT:0001764 homeostasis trait
VT:0002644 blood triglyceride amount
VT:0005007 bone mineral mass
VT:0005667 blood leptin amount
VT:0010139 immune response trait
VT:0010482 body fat mass
VT:0010483 body lean mass

Investigators	Ed Leiter The Jackson Laboratory, Bar Harbor, ME
Participants	Reifsnyder PC, Wallace R, Li R, King B, Churchill GC
Contact	Ed Leiter ed.leiter@jax.org
Affiliated Center	QTL Archive
Acknowledgements	This work was supported by grants NIH-RR09781 and DK75000 (E.H.L.) and GM070683 (G.C.C.). Institutional shared services were supported by NCI Center Support Grant CA34196.
Project type	QTL Archive data set
MPD identifiers	Leiter2 MPD:240
Data changelog	No updates/corrections. Initial release date: 01/2008.

QTL data set parameters:

Progenitor strains	129S1/Sv.NOD-H2g7 NOD/ShiLtJ
Cross direction notation	NOD x (NOD x 129.H2g7)
Cross type	Backcross
Population size	310 ♀ 0 ♂
Notes	N2 progeny

Measured phenotypes: To access these data use the QTL Data Downloads button at bottom of page.

Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	Sex	Age	Sample Size (Avg)
Leiter2	health assessment	(none)	age of diabetes onset (dash = no diabetes) [wks] Onset 24001	QTL population	f	14-40wks	N=310

Leiter2	health assessment	(none)	1 = diabetes, 0 = no diabetes [score] DB1_0 24002	QTL population	f	14-40wks	N=310

Leiter2	histopathology	(none)	combination score of age at type 1 diabetes onset, and insulitis severity / extent (see excel file) [score] Insulities_TimeOnset 24003	QTL population	f	14-40wks	N=310

Leiter2	histopathology	(none)	insulitis severity / extent score (0-4, see excel file) [score] Insulitis 24004	QTL population	f	14-40wks	N=310

Leiter2	histopathology	(none)	group mice by insulitis score (0-3, see excel file) [score] GroupInsulitis_Diabetes 24005	QTL population	f	14-40wks	N=310

Leiter2	body weight	(none)	body weight at 30 wks of age (if alive, mice were sacrificed when determined to be diabetic 2 wks in a row) [g] 30wk 24006	QTL population	f	30wks	N=310

Leiter2	body weight	(none)	body weight at 40 wks of age (if alive, mice were sacrificed when determined to be diabetic 2 wks in a row) [g] 40wk 24007	QTL population	f	40wks	N=310

Leiter2	body weight	(none)	body weight of whole mouse at time of DXA [g] BW 24008	QTL population	f	14-40wks	N=310

Leiter2	DXA	(none)	bone mineral density (BMD), as determined by DXA, head excluded [g/cm²] BMD 24009	QTL population	f	14-40wks	N=310

Leiter2	DXA	(none)	bone mineral content (BMC), as determined by DXA, head excluded [g] BMC 24010	QTL population	f	14-40wks	N=310

Leiter2	DXA	(none)	bone mineral area, as determined by DXA, head excluded [cm²] Area 24011	QTL population	f	14-40wks	N=310

Leiter2	DXA	(none)	weight of muscle and organs, as determined by DXA [g] Lean 24012	QTL population	f	14-40wks	N=310

Leiter2	DXA	(none)	weight of fat, as determined by DXA [g] Fat 24013	QTL population	f	14-40wks	N=310

Leiter2	DXA	(none)	total weight, as determined by DXA [g] Total 24014	QTL population	f	14-40wks	N=310

Leiter2	DXA	(none)	percentage of fat of total weight as determined by DXA [%] %Fat 24015	QTL population	f	14-40wks	N=310

Leiter2	hormone quantification	(none)	leptin in plasma [ng/mL] Leptin 24016	QTL population	f	14-40wks	N=310

Leiter2	hormone quantification	(none)	insulin in plasma [ng/mL] Insulin 24017	QTL population	f	14-40wks	N=310

Leiter2	lipid profile	(none)	total cholesterol in plasma [mg/dL] CHOL 24018	QTL population	f	14-40wks	N=310

Leiter2	lipid profile	(none)	HDLD cholesterol in plasma [mg/dL] HDLD 24019	QTL population	f	14-40wks	N=310

Leiter2	metabolic panel	(none)	glucose in plasma [mg/dL] Glucose 24020	QTL population	f	14-40wks	N=310

Leiter2	lipid profile	(none)	non-Esterified Fatty Acids in plasma [mEq/L] NEFA 24021	QTL population	f	14-40wks	N=310

Leiter2	lipid profile	(none)	triglycerides in plasma [mg/dL] TG 24022	QTL population	f	14-40wks	N=310

To see more rows use the paging control at top.

Project / data set: Leiter2 a.k.a. Leiter_2009
Excel file: Data_Description_NODx129_Leiter2009.xlsx
CSV file: Leiter2009_NODx129_B37_Data.csv
Readme / text file: readme_Leiter2009.txt
QC plots, figures, etc.: QCReport_Leiter2009.pdf