MPD: Data set: Ishimori1

Ishimori1: Plasma HDL cholesterol, obesity, and atherosclerosis susceptibility in F2 progeny from a C57BL/6J x 129S1/SvImJ intercross (2004)

Ishimori N, Churchill GA With: Li R, Kelmenson PM, Korstanje R, Walsh KA, Forsman-Semb K, Paigen B

Ishimori1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.

Ontology terms mapped to Ishimori1 measures:

MA:0000009 adipose tissue
MA:0000059 blood
MA:0000062 aorta
MA:0000309 vertebra
MA:0000358 liver
MA:0002501 plasma
MP:0000180 abnormal circulating cholesterol level
MP:0000184 abnormal circulating HDL cholesterol level
MP:0001259 abnormal body weight
MP:0002903 abnormal circulating parathyroid hormone level
MP:0004847 abnormal liver weight
MP:0005340 altered susceptibility to atherosclerosis
MP:0005457 abnormal percent body fat/body weight
MP:0010119 abnormal bone mineral density
MP:0011969 abnormal circulating triglyceride level
MP:0020098 abnormal susceptibility to diet-induced aortic fatty streak lesions
MP:0020151 abnormal circulating non-HDL cholesterol level
MP:0020182 abnormal body mass index
VT:0000180 blood cholesterol amount
VT:0000184 blood HDL cholesterol amount
VT:0000272 aorta morphology trait
VT:0001259 body mass
VT:0002644 blood triglyceride amount
VT:0002903 blood parathyroid hormone amount
VT:0003402 liver mass
VT:0005007 bone mineral mass
VT:0010474 blood non-HDL cholesterol amount
VT:0010482 body fat mass

Investigators	N Ishimori Gary A Churchill The Jackson Laboratory, Bar Harbor, ME
Participants	Li R, Kelmenson PM, Korstanje R, Walsh KA, Forsman-Semb K, Paigen B
Contact	Gary A Churchill gary.churchill@jax.org
Affiliated Center	QTL Archive
Acknowledgements	Funding provided by NIH Grants CA34196, HL66611 and AR43618; AstraZeneca; Japan Heart Foundation/BayerYakuhin Research Grant Abroad; Japan Heart Foundation/Pfizer Grant for Research on Hypertension, Hyperlipidemia, and Vascular Metabolism.
Project type	QTL Archive data set
MPD identifiers	Ishimori1 MPD:140
Data changelog	No updates/corrections. Initial release date: 01/2008.

An intercross between C57BL/6J and 129S1/SvImJ inbred mouse strains was generated to identify QTLs involved in plasma HDL cholesterol concentrations, obesity, and susceptibility to atherosclerosis. Body and liver weight, body composition, bone mineral density, blood lipids, parathyroid hormone levels, and aortic lesion size were measured in mice administered a high-fat (15%) diet from 6-20 wks of age (14 wks on high fat diet). Plasma was obtained from fasted mice (4 hr). For detailed protocols see publications (below).

QTL data set parameters:

Progenitor strains	129S1/SvImJ C57BL/6J
Cross direction notation	(B6x129) F1 x (B6x129) F1
Cross type	F2 intercross
Population size	294 ♀ 0 ♂
Age	20wks

Measured phenotypes: To access these data use the QTL Data Downloads button at bottom of page.

Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	Sex	Age	Sample Size (Avg)
Ishimori1	body weight	high-fat diet	body weight [g] bw 14001	QTL population	f	20wks	N=294

Ishimori1	organ weights	high-fat diet	liver weight [g] liver_wt 14002	QTL population	f	20wks	N=294

Ishimori1	lipid profile	high-fat diet	HDL cholesterol (plasma) [mg/dL] HDLC 14003	QTL population	f	20wks	N=294

Ishimori1	lipid profile	high-fat diet	HDL cholesterol (plasma), log transformed [log(mg/dL)] HDLC_log 14004	QTL population	f	20wks	N=294

Ishimori1	lipid profile	high-fat diet	non-HDL cholesterol (plasma) [mg/dL] nonHDLC 14005	QTL population	f	20wks	N=294

Ishimori1	lipid profile	high-fat diet	non-HDL cholesterol (plasma), log transformed [log(mg/dL)] nonHDL_log 14006	QTL population	f	20wks	N=294

Ishimori1	lipid profile	high-fat diet	total cholesterol (plasma) [mg/dL] chol 14007	QTL population	f	20wks	N=294

Ishimori1	lipid profile	high-fat diet	triglycerides (plasma) [mg/dL] TG 14008	QTL population	f	20wks	N=294

Ishimori1	histopathology	high-fat diet	fatty streak aortic lesions (0=absent, 1=present) [score] aortic_lesion_presence 14009	QTL population	f	20wks	N=294

Ishimori1	histopathology	high-fat diet	fatty streak aortic lesion size [µm²] aortic_lesion 14010	QTL population	f	20wks	N=294

Ishimori1	histopathology	high-fat diet	fatty streak aortic lesion size, log transformed [log(µm²)] aortic_lesion_log 14011	QTL population	f	20wks	N=294

Ishimori1	DXA	high-fat diet	total body area bone mineral density (BMD) [mg/mm²] BMD_total 14012	QTL population	f	20wks	N=294

Ishimori1	DXA	high-fat diet	vertebral areal bone mineral density (BMD) [mg/mm²] BMD_vertebral 14013	QTL population	f	20wks	N=294

Ishimori1	DXA	high-fat diet	percentage of body weight that is fat [%] pct_fat 14014	QTL population	f	20wks	N=294

Ishimori1	body weight	high-fat diet	body mass index (BMI) [g/cm²] BMI 14015	QTL population	f	20wks	N=294

Ishimori1	body weight	high-fat diet	body mass index (BMI), log transformed [log(g/cm²)] BMI_log 14016	QTL population	f	20wks	N=294

Ishimori1	hormone quantification	high-fat diet	parathyroid hormone [pg/mL] PTH 14017	QTL population	f	20wks	N=294

Ishimori1	hormone quantification	high-fat diet	parathyroid hormone, log transformed [log(pg/mL)] PTH_log 14018	QTL population	f	20wks	N=294

To see more rows use the paging control at top.

Associated genomic features

MGI-curated QTL / genomic features that have been associated with this data set:
Aorls1 Ath17 Ath18 Ath19 Ath20 Ath21 Bmd20 Bmd21 Bmd22 Bmd23 Hdlq14 Hdlq15 Hdlq16 Hdlq17 Hdlq18 Hdlq19 Mobq2 Nhdlq1 Nhdlq14 Nhdlq4 Nhdlq5 Nhdlq6 Nhdlq7 Obq16 Obq17 Obq18 Obq19 Tgq1 Tgq2 Tgq3

Project / data set: Ishimori1 a.k.a. Ishimori_2004
Excel file: Data_Description_B6x129_Ishimori2004.xlsx
CSV file: Ishimori2004_B6x129_B37_Data.csv
Readme / text file: readme_Ishimori2004.txt
QC plots, figures, etc.: QCReport_Ishimori2004.pdf

References (chronological)

1. Ishimori N, Li R, Kelmenson PM, Korstanje R, Walsh KA, Churchill GA, Forsman-Semb K, Paigen B. Quantitative Trait Loci Analysis for Plasma HDL-Cholesterol Concentrations and Atherosclerosis Susceptibility Between Inbred Mouse Strains C57BL/6J and 129S1/SvImJ. Arterioscler Thromb Vasc Biol. 2004 Jan;24(1):161-6. Epub 2003 Oct 30. PubMed 14592847

2. Ishimori N, Li R, Kelmenson PM, Korstanje R, Walsh KA, Churchill GA, Forsman-Semb K, Paigen B. Quantitative trait loci that determine plasma lipids and obesity in C57BL/6J and 129S1/SvImJ inbred mice. J Lipid Res. 2004 Sep;45(9):1624-32. Epub 2004 Jun 21. PubMed 15210844

3. Ishimori N, Li R, Walsh KA, Korstanje R, Rollins JA, Petkov P, Pletcher MT, Wiltshire T, Donahue LR, Rosen CJ, Beamer WG, Churchill GA, Paigen B. Quantitative trait loci that determine BMD in C57BL/6J and 129S1/SvImJ inbred mice. J Bone Miner Res. 2006 Jan;21(1):105-12. Epub 2005 Sep 9. PubMed 16355279

4. Ackert-Bicknell CL, Karasik D, Li Q, Smith RV, Hsu YH, Churchill GA, Paigen BJ, Tsaih SW. Mouse BMD quantitative trait loci show improved concordance with human genome-wide association loci when recalculated on a new, common mouse genetic map. J Bone Miner Res. 2010 Aug;25(8):1808-20. PubMed 20200990