HMDPpheno11: Diet effects on aortic lesion size in 103 Hybrid Mouse Diversity Panel strains that are transgenic for human APOE*3Leiden and human CETP (F1 hybrids) (2015)
Bennett BJ, Davis RC, Civelek M, Orozco L, Wu J, Qi H, Pan C, Packard RR, Eskin E, Yan M, Kirchgessner T, Wang Z, Li X, Gregory JC, Hazen SL, Gargalovic PS, Lusis AJ. Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains.
PLoS Genet. 2015 Dec;11(12):e1005711. doi: 10.1371/journal.pgen.1005711. Epub 2015 Dec 22.
HMDPpheno11 downloads
• Download HMDPpheno11 project data set animal data, as uploaded
• Download HMDPpheno11 animal data matrix with factor-related expansion applied as necessary
• Download HMDPpheno11 strain means, SD, N, etc. one row per strain/sex/measure
• Download HMDPpheno11 project data set animal data, as uploaded
• Download HMDPpheno11 animal data matrix with factor-related expansion applied as necessary
• Download HMDPpheno11 strain means, SD, N, etc. one row per strain/sex/measure
Ontology terms mapped to HMDPpheno11 measures:
| Investigators |
Brian J Bennett University of North Carolina, Chapel Hill, NC Aldons J Lusis University of California, Los Angeles, Los Angeles, CA |
| Participants | Davis RC, Civelek M, Orozco L, Wu J, Qi H, Pan C, Packard RR, Eskin E, Yan M, Kirchgessner T, Wang Z, Li X, Gregory JC, Hazen SL, Gargalovic PS |
| Contact | Aldons J Lusis jlusis@mednet.ucla.edu
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| Affiliated Center | Hybrid Mouse Diversity Panel Group (HMDP) |
| Acknowledgements | Mice carrying the human ApoE3 Leiden variant were kindly provided by Dr. L. Havekes, Leiden University Medical Center, Leiden, Netherlands |
| Funding Provided By | Funding provided by NIH HL103866, HL113452, HL30568, HL28481, HL102223, HL121172; Transatlantic Networks of Excellence Award (12CVD03) from Foundation Leducq |
| Phenotype strain survey data set | |
| MPD identifiers | HMDPpheno11 MPD:1013 |
| No updates/corrections. Initial release date: 01/2020. | |
|
Click above to copy-paste the entire citation for this MPD web page. |
Male C57BL/6J mice carrying the dominant human transgenes for ApoE*3 Leiden variant and CETP were crossed with females of approximately 100 inbred strains from the Hybrid Mouse Diversity Panel (HDMP). At the age of 8 weeks, F1 progeny carrying both transgenes were placed on a high-fat diet supplemented with 1.0% cholesterol. Test mice were euthanized at approximately 24 weeks of age, and the lesion area in the proximal aorta was assessed.
Experimental groups in this study:
• high-fat high-cholesterol diet
Procedures conducted:
Experimental groups in this study:
Procedures conducted:
| Aortic lesion size after 16 wks on high-fat diet. |
