Golani1 comparability

Anxiety-related behavior in 8 inbred strains of mice surveyed in three laboratories   (2003)

Golani I, Elmer GI, Kafkafi N, Benjamini Y
With: Lipkind D, Sakov A, Fonio A, Horev G, Dvorkin A, Mayo CL


Comparability across labs

Tests were conducted in three laboratories. The following table shows measurement correlations between labs. All mice were males, with data for 8 strains supplied by each lab. TAU = Tel Aviv University (Golani, Benjamini); NIDA = National Institute on Drug Abuse (Kafkafi); MPRC = Maryland Psychiatric Research Center (Elmer).

MeasurementMPRC
vs.
NIDA		MPRC
vs.
TAU		NIDA
vs.
TAU
DST 0.91 0.93 0.97
LMXHS 0.72 0.62 0.87
DSTRD 0.61 0.85 0.70
NP 0.95 0.91 0.95
LNGP 0.81 0.91 0.86
PMXS 0.86 0.96 0.93
MSDR 0.83 0.85 0.87
TRADA 0.83 0.93 0.90
TTRN 0.94 0.91 0.95
LMS 0.78 0.87 0.94
TL 0.89 0.92 0.96
SPTL 0.78 0.69 0.84
DVRS 0.91 0.91 0.97
CNTRT 0.94 0.94 0.81
HBO 0.88 0.95 0.87
NEXC 0.88 0.93 0.95
NLEXC 0.47 0.91 0.66
 
MeasurementMPRC
vs.
NIDA		MPRC
vs.
TAU		NIDA
vs.
TAU
MCW 0.88 0.85 0.96
MCC 0.93 0.81 0.92
MLDW 0.74 0.85 0.85
MLDC 0.93 0.52 0.73
NI 0.95 0.95 0.91
MIL 0.98 0.88 0.91
MIMWD 0.94 0.71 0.76
PIBS 0.95 0.87 0.94
ASLI 0.96 0.88 0.97
OISRI 0.89 0.89 0.96
MCNW 0.97 0.93 0.93
MCI 0.93 0.78 0.79
MCAC 0.90 0.77 0.92
NNW 0.85 0.43 0.18
NII 0.99 0.92 0.95
NAC 0.96 0.88 0.97

A significant lab x strain interaction was noted for C3H/HeJ mice, particularly for number of near-wall incursions (NNW) which seems to be more sensitive to environmental variation than the other incursion types.