Esposito1: Spontaneous morphological phenotypes in 6 inbred strains of mice (2013)
Serpi R, Klein-Rodewald T, Calzada-Wack J, Neff F, Schuster T, Gailus-Durner V, Fuchs H, Poutanen M, Hrabrè de Angelis M, Esposito I. Inbred wild type mouse strains have distinct spontaneous morphological phenotypes.
Histol Histopathol. 2013 Jan;28(1):79-88.
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| Investigators |
Irene Esposito Technische Universitaet Muenchen, Munich GERMANY |
| Participants | Serpi R, Klein-Rodewald T, Calzada-Wack J, Neff F, Schuster T, Gailus-Durner V, Fuchs H, Poutanen M, Hrabě de Angelis M |
| Contact | Irene Esposito Esposito@lrz.tu-muenchen.de
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| Acknowledgements | Funding provided by the Academy of Finland (251736), Finnish Cardiovascular Foundation, Finnish Cultural Foundation, Sigrid Juselius Foundation, Company of Biologists, German Federal Ministry of Education and Research (NGFNPlus, 01GS0850), the German Research Foundation (SFB824, Project Z2), the European Community Erasmus Lifelong Learning Program (517860-LLP-1-2011-F1-ERASMUS-FEXI), European Community (EUMODIC LSHG-2006-037188) |
| Phenotype archive study | |
| MPD identifiers | Esposito1 MPD:486 |
| No updates/corrections. Initial release date: 08/2013. | |
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Click above to copy-paste the entire citation for this MPD web page. |
• Download supplemental data set (xlsx) ... all diagnoses w/ comments
Frequency rates (%) of disorders seen during histopathology survey of various organs.
| Females | Males | |||||||||||||
| Organ | Disorder |  |
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N animals examined |
10 | 13 | 16 | 16 | 10 | 12 | 10 | 13 | 16 | 16 | 10 | 12 | ||
| adrenal gland | accessory cortical nodule | 10 | 8 | – | – | 30 | 17 | 20 | – | – | – | 10 | 8 | |
| adrenal gland | subcapsular cell hyperplasia | – | 92 | 94 | 81 | 50 | – | – | 92 | 69 | 6 | 10 | – | |
| adrenal gland | subcapsular cell hypertrophy | – | – | – | – | – | 17 | – | – | – | – | – | – | |
| heart | calcification | – | 23 | – | – | – | – | – | 23 | – | – | – | – | |
| heart | lipomatosis | – | – | – | – | – | 25 | – | – | – | – | – | 8 | |
| intestine, large | Peyer's patch | 20 | 77 | 38 | 25 | 40 | 25 | 50 | 54 | 56 | 19 | 30 | 33 | |
| intestine, small | Peyer's patch | – | – | 50 | – | – | – | – | – | 12 | – | – | – | |
| kidney | focal inflammation | – | – | – | – | – | 17 | – | – | – | – | – | – | |
| kidney | hydronephrosis | – | – | – | 6 | 10 | – | 20 | – | – | – | – | – | |
| kidney | pyelonephritis | 20 | – | 12 | – | – | – | – | – | 12 | – | 20 | – | |
| liver | extramedullary hematopoiesis | – | – | – | 31 | – | 33 | – | – | – | 12 | – | 8 | |
| liver | focal necrosis | – | – | 19 | 6 | – | 33 | – | 8 | 19 | – | – | 8 | |
| liver | steatosis | – | – | 6 | – | – | – | – | 77 | – | – | – | – | |
| lung | bronchus associated lymphoid tissue | 10 | 77 | 38 | – | 10 | 33 | 10 | 31 | 25 | – | 20 | 25 | |
| lung | focal infarction | – | – | – | – | – | – | – | – | 19 | – | – | – | |
| lung | pneumonia | 40 | – | – | – | – | 8 | – | – | – | – | – | – | |
| ovary | follicular cyst | – | – | 12 | – | – | – | |||||||
| ovary | thickened membrane | – | – | – | 31 | – | – | |||||||
| pancreas | lipomatosis | – | – | 50 | – | – | 67 | – | – | 19 | 6 | – | 50 | |
| salivary gland | lipomatosis | – | – | 12 | – | – | – | – | – | 12 | – | – | – | |
| stomach | dilated glands | 20 | – | – | – | – | – | – | – | – | – | – | – | |
| testis | atrophy | 20 | – | – | – | – | – | |||||||
| thyroid | ectopic thymus | – | – | – | 6 | 10 | – | – | – | – | 6 | 10 | – | |
| urinary bladder | cystitis | – | 8 | 6 | – | – | – | 10 | – | – | – | 10 | – | |
Dash (–) indicates 0 %.
Animal ages: 17 to 23 wks.