MPD: Data set: Dorward1

Dorward1: Ovarian granulosa cell tumors in F2 progeny from the CAST/EiJ x SWXJ9/BmJ intercross (2005)

Dorward AM, Shultz KL, Horton LG, Li R, Churchill GA, Beamer WG. Distal Chr 4 harbors a genetic locus (Gct1) fundamental for spontaneous ovarian granulosa cell tumorigenesis in a mouse model. Cancer Res. 2005 Feb 15;65(4):1259-64. PubMed 15735010

Dorward1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.

Ontology terms mapped to Dorward1 measures:

Investigators	A M Dorward Gary A Churchill The Jackson Laboratory, Bar Harbor, ME
Participants	Shultz KL, Horton LG, Li R, Beamer WG
Contact	Gary A Churchill gary.churchill@jax.org
Affiliated Center	QTL Archive
Acknowledgements	Cancer Research Foundation of America fellowship (A.M. Dorward); Maine Cancer Foundation grant (A.M. Dorward); American Institute for Cancer Research grant (W.G. Beamer); NIH grants CA88327 (G.A. Churchill and R. Li), AR43618 (W.G. Beamer and L.G. Horton); and Strawbridge Foundation and National Cancer Institute Cancer Core grant CA34196 (The Jackson Laboratory).
Project type	QTL Archive data set
MPD identifiers	Dorward1 MPD:163
Data changelog	No updates/corrections. Initial release date: 10/2009.

An intercross of the SWXJ9/BmJ recombinant inbred strain and CAST/EiJ was generated to identify QTLs affecting ovarian granulosa cell tumors. For detailed information see Dorward et al 2005.

QTL data set parameters:

Progenitor strains	CAST/EiJ SWXJ9/BmJ
Cross direction notation	(CASTxSWXJ9) F1 x SWXJ9
Cross type	N2F1 backcross
Population size	162 ♀ 0 ♂
Age	8wks

Measured phenotypes: To access these data use the QTL Data Downloads button at bottom of page.

Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Dorward1	histopathology	(none)	presence of ovarian granulosa cell tumor (0=normal 1=tumor) [designation] GC-tumor 16301	QTL population		f	8wks	N=162

Associated genomic features

MGI-curated QTL / genomic features that have been associated with this data set:
Gct1 Gct5 Gct7 Gct8 Gct9

Project / data set: Dorward1 a.k.a. Dorward_2005
Excel file: ._Data_Description_SWXJxCAST_Dorward2005.xlsx
Excel file: Data_Description_CASTxSWXJ_Dorward2005.xlsx
CSV file: ._Dorward2005_SWXJxCAST_B37_Data.csv
CSV file: Dorward2005_CASTxSWXJ_BC_B37_Data.csv
Readme / text file: ._readme.txt
Readme / text file: readme_Dorward2005.txt
QC plots, figures, etc.: QCReport_Dorward2005.pdf