MPD: Data set: Dietrich1

Dietrich1: Bacillus anthracis lethal toxin susceptibility in females of 50 strains of mice (1998)

Dietrich WF With: Watters JW, Boyden ED, Roberts JE, Ballard JD, Dewar K, Lehoczky J, Boyartchuk V

Dietrich1 downloads
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Ontology terms mapped to Dietrich1 measures:

Investigators	William F Dietrich Harvard Medical School, Boston, MA
Participants	Watters JW, Boyden ED, Roberts JE, Ballard JD, Dewar K, Lehoczky J, Boyartchuk V
Contact	William F Dietrich Lab web site
Acknowledgements	Funding provided by Howard Hughes Medical Institute; NIH AI22021, AI43321
Project type	Phenotype strain survey data set
MPD identifiers	Dietrich1 MPD:15
Data changelog	3 updates/corrections. Initial release date: 12/2001.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

"Resistant" is defined as cells that show greater than 90% viability when incubated 4 hr with lethal factor (LF; 10 micrograms/milliliter) and protective antigen (PA; 1 microgram/milliliter). "Susceptible" is defined as cells that show less than 10% viability under the same conditions.

Procedures conducted:

• in vitro assay

Bacillus anthracis lethal toxin (anthrax) susceptibility.

Mice: inbred 50 strains ♀ age 6-8wks* 1 experimental group

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Dietrich1:1	Dietrich1	in vitro assay	Bacillus anthracis lethal toxin	susceptibility to Bacillus anthracis (0=susceptible, 1=resistant) [designation] anthrax_lethal_toxin 1501	inbred	50	f	6-8wks*

References (chronological)

1. Roberts JE, Watters JW, Ballard JD, Dietrich WF. Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11. Mol Microbiol. 1998 Jul;29(2):581-91. PubMed 9720874

2. Watters JW, Dietrich WF. Genetic, physical, and transcript map of the Ltxs1 region of mouse chromosome 11. Genomics. 2001 Apr 15;73(2):223-31. PubMed 11318612

3. Watters JW, Dewar K, Lehoczky J, Boyartchuk V, Dietrich WF. Kif1C, a kinesin-like motor protein, mediates mouse macrophage resistance to anthrax lethal factor. Curr Biol. 2001 Oct 2;11(19):1503-11. PubMed 11591317

4. Boyden ED, Dietrich WF. Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet. 2006 Feb;38(2):240-4. Epub 2006 Jan 22. PubMed 16429160