MPD: Data set: DiCurzio1

DiCurzio1: Adrenal gland weight and morphology in 64 BXD recombinant inbred strains of mice (2010)

Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ. High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains. Genes Brain Behav. 2010 Mar 1;9(2):129-59. Epub 2009 Sep 22. PubMed 19958391 FullText

Di Curzio DL, Goldowitz D. The genetic basis of adrenal gland weight and structure in BXD recombinant inbred mice. Mamm Genome. 2011 Apr;22(3-4):209-34. Epub 2011 Feb 24. PubMed 21347846

DiCurzio1 downloads
• Download DiCurzio1 project data set animal data, as uploaded
• Download DiCurzio1 animal data matrix with factor-related expansion applied as necessary
• Download DiCurzio1 strain means, SD, N, etc. one row per strain/sex/measure
• DiCurzio1 supplementary data

Ontology terms mapped to DiCurzio1 measures:

MA:0000116 adrenal gland
MP:0001259 abnormal body weight
MP:0008289 abnormal adrenal medulla morphology
MP:0008293 abnormal adrenal gland zona glomerulosa morphology
MP:0008294 abnormal adrenal gland zona fasciculata morphology
MP:0008295 abnormal adrenal gland zona reticularis morphology
MP:0008296 abnormal adrenal gland x-zone morphology
MP:0011921 abnormal adrenal gland zona intermedia morphology
MP:0012689 abnormal adrenal gland weight
VT:0000639 adrenal gland morphology trait
VT:0000643 adrenal central medulla morphology trait
VT:0000646 adrenocortical cell morphology trait
VT:0001259 body mass

Investigators	Domenico L Di Curzio University of Manitoba, Winnipeg, Manitoba CANADA Daniel Goldowitz University of British Columbia, Vancouver British Columbia CANADA
Contact	Daniel Goldowitz dang@cmmt.ubc.ca Lab web site
Acknowledgements	Funding provided by NIH DA020677 and AA016666 Animals used in this study were provided primarily by Oak Ridge National Laboratory.
Project type	Phenotype strain survey data set
MPD identifiers	DiCurzio1 MPD:366
Data changelog	No updates/corrections. Initial release date: 04/2011.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Procedures conducted:

• body weight
• organ weights		Adrenal weight.
• histopathology		Adrenal glands.

Mice: BXD w/par 66 strains ♀♂ age 10wks 1 experimental group

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
DiCurzio1:1	DiCurzio1	body weight	(none)	body weight at testing [g] bw 36601	BXD w/par	66	both	7-10wks*	N=4

DiCurzio1:2	DiCurzio1	organ weights	(none)	adrenal weights [mg] adr_wt 36602 left right	BXD w/par	66	both	7-10wks*	N=4

DiCurzio1:4	DiCurzio1	organ weights	(none)	mean weight of both adrenals [mg] adr_wt_ave 36604	BXD w/par	66	both	7-10wks*	N=4

DiCurzio1:5	DiCurzio1	organ weights	(none)	total weight of adrenals adjusted to body weight (x10^-3) [mg] adr_adj_bw 36605	BXD w/par	66	both	7-10wks*	N=4

DiCurzio1:6	DiCurzio1	histopathology	(none)	adrenal total width, diameter [µm] adr_width 36606	BXD w/par	66	both	7-10wks*	N=3

DiCurzio1:7	DiCurzio1	histopathology	(none)	adrenal medulla width [µm] adr_medul_width 36607	BXD w/par	66	both	7-10wks*	N=3

DiCurzio1:8	DiCurzio1	histopathology	(none)	adrenal cortex zona glomerulosa thickness [µm] adr_glome_width 36608	BXD w/par	66	both	7-10wks*	N=3

DiCurzio1:9	DiCurzio1	histopathology	(none)	adrenal cortex zona intermedia thickness [µm] adr_inter_width 36609	BXD w/par	66	both	7-10wks*	N=3

DiCurzio1:10	DiCurzio1	histopathology	(none)	adrenal cortex zona fasciculata thickness [µm] adr_fasci_width 36610	BXD w/par	66	both	7-10wks*	N=3

DiCurzio1:11	DiCurzio1	histopathology	(none)	adrenal cortex zona reticularis thickness [µm] adr_retic_width 36611	BXD w/par	66	both	7-10wks*	N=3

DiCurzio1:12	DiCurzio1	histopathology	(none)	adrenal cortex X-zone thickness [µm] adr_Xzone_width 36612	BXD w/par	66	both	7-10wks*	N=3

DiCurzio1:14	DiCurzio1	histopathology	(none)	adrenal glands, presence of X-zone (0=no; 1=yes) [score] Xzone_presence 36614	BXD w/par	66	both	7-10wks*	N=4

DiCurzio1:15	DiCurzio1	histopathology	(none)	adrenal glands, presence of lipoid structures in females (0=none; 1=outside X-zone; 2=within X-zone) [score] lipoid_presence 36615	BXD w/par	66	f	7-10wks*	N=4

DiCurzio1:80	DiCurzio1	colony observation	(none)	age at testing (local parameter) [wks] age 36680	BXD w/par	66	both		N=4