Bubier3: Drug study: Opioid induced respiratory depression in 8 inbred founder strains of the Collaborative Cross (2020)
Bubier JA, He H, Philip VM, Roy T, Hernandez CM, Bernat R, Donohue KD, O'Hara BF, Chesler EJ. Genetic variation regulates opioid-induced respiratory depression in mice.
Sci Rep. 2020 Sep 11;10(1):14970. doi: 10.1038/s41598-020-71804-2.
Bubier3 downloads
• Download Bubier3 project data set animal data, as uploaded
• Download Bubier3 animal data matrix with factor-related expansion applied as necessary
• Download Bubier3 strain means, SD, N, etc. one row per strain/sex/measure
• Download Bubier3 project data set animal data, as uploaded
• Download Bubier3 animal data matrix with factor-related expansion applied as necessary
• Download Bubier3 strain means, SD, N, etc. one row per strain/sex/measure
Ontology terms mapped to Bubier3 measures:
| Investigators |
Jason A Bubier The Jackson Laboratory, Bar Harbor, ME Elissa J Chesler The Jackson Laboratory, Bar Harbor, ME |
| Participants | He H, Philip V, Donohue KD, O'Hara B |
| Contact | Jason A Bubier jason.bubier@jax.org |
| Affiliated Center | Center for Systems Neurogenetics of Addiction (CSNA) |
| Acknowledgements | NIH NIDA Drug Supply Program |
| Funding Provided By | NIH DA037927, AA018776, DA039841, DA048890, HL142489 |
| Phenotype strain survey data set | |
| MPD identifiers | Bubier3 MPD:649 |
| No updates/corrections. Initial release date: 12/2020. | |
|
Click above to copy-paste the entire citation for this MPD web page. |
This study measured respiratory phenotypes using signals obtained from a piezo electric sleep monitoring system in the eight founder strains of the Collaborative Cross and Diversity Outbred populations. This system offers a non-invasive, high-throughput technology to study respiratory depression in response to opioids in mice in a home-cage setting. The piezo technology was adapted to estimate average respiratory rates over specified time intervals for characterizing patterns associated with respiratory depression. This allows for the determination of respiratory depression and time to recovery or cessation of respiration.
Experimental groups in this study:
• Morphine
Procedures conducted:
Experimental groups in this study:
Procedures conducted:
| Induced respiratory depression, time to recovery (for mice that survived), survival data (for mice that did not survive). |
