MPD: Project measures / variables set: Gould3 FC

Project measures / variables set: Gould3 FC_immediate

ID, description, units	MPD:47341 FC_immediate withdrawal study group, percent immobility in training chamber after first stimulus pairing [%] nicotine study
Measures	• control • nicotine dose (mg) • 3 • 6.3 • 12
Data set, strains	Gould3 inbred 8 strains sex: m age: 8-12wks
Procedure	fear conditioning test
Comparison	control group vs. multiple treatment / dosage groups
Ontology mappings	VT:0010527 associative learning trait VT:0010715 fear-related behavior trait VT:0010721 response to nicotine trait VT:0010722 withdrawal response to addictive substance trait MP:0002062 abnormal associative learning MP:0003106 abnormal fear-related response MP:0009774 abnormal behavioral withdrawal response MP:0020160 abnormal behavioral response to nicotine

Values Means Δ Means Z-scores

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Gould3 - withdrawal study group, percent immobility in training chamber after first stimulus pairing

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
dose	3	430.0884	143.3628	1.3743	0.2504
strain	7	85955.805	12279.4007	117.7164	< 0.0001
dose:strain	21	1363.8374	64.9446	0.6226	0.902
Residuals	336	35049.3187	104.3134

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Gould3	47341	fear conditioning test	nicotine	withdrawal study group, percent immobility in training chamber after first stimulus pairing [%] control FC_immediate_0	inbred	8	m	8-12wks
Gould3	47342	fear conditioning test	nicotine	withdrawal study group, percent immobility in training chamber after first stimulus pairing [%] dose: 3 mg FC_immediate_3	inbred	8	m	8-12wks
Gould3	47343	fear conditioning test	nicotine	withdrawal study group, percent immobility in training chamber after first stimulus pairing [%] dose: 6.3 mg FC_immediate_6	inbred	8	m	8-12wks
Gould3	47344	fear conditioning test	nicotine	withdrawal study group, percent immobility in training chamber after first stimulus pairing [%] dose: 12 mg FC_immediate_12	inbred	8	m	8-12wks