MPD: Project measures / variables set: Harrill2 ALT

Project measures / variables set: Harrill2 ALT

ID, description, units	MPD:44111 ALT alanine transaminase (serum ALT) [IU/L] DB289 study
Measures	• control • DB289 • difference
Data set, strains	Harrill2 inbred 34 strains sex: f age: 6-8wks
Procedure	metabolic panel
Comparison	control group vs. treated group
Ontology mappings	VT:0010487 response to xenobiotic stimulus trait VT:0001573 blood alanine transaminase amount MA:0002502 serum MP:0008872 abnormal physiological response to xenobiotic MP:0001573 abnormal circulating alanine transaminase level

Values Means Δ Means Z-scores

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Harrill2 - alanine transaminase (serum ALT)

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
group	1	420905.9212	420905.9212	574.9441	< 0.0001
strain	33	229885.9189	6966.24	9.5157	< 0.0001
group:strain	33	160643.5906	4867.9876	6.6495	< 0.0001
Residuals	268	196197.8235	732.0814

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Harrill2	44111	metabolic panel	DB289	alanine transaminase (serum ALT) [IU/L] control ALT_ctrl	inbred	34	f	6-8wks
Harrill2	44112	metabolic panel	DB289	alanine transaminase (serum ALT) [IU/L] DB289 ALT_trt	inbred	34	f	6-8wks
Harrill2	44211	metabolic panel	DB289	alanine transaminase (serum ALT) [IU/L] difference ALT_fold	inbred	34	f	6-8wks	(supplemental / summary measure)