MPD: Project measures / variables set: Thomsen2 activ

Project measures / variables set: Thomsen2 activ_D1

ID, description, units	MPD:40801 activ_D1 total activity, dose response to D1 agonist, 3h test [n] R-6-Br-APB study
Measures	• baseline • dose mg/kg i.p. • 0.03 • 0.32 • 3.2 • 5.6
Data set, strains	Thomsen2 inbred 15 strains sex: both age: 8-10wks
Procedure	open field test
Comparison	repeated measures, baseline then treated multiple doses, same cohort
Ontology mappings	VT:0001392 locomotor behavior trait VT:0010487 response to xenobiotic stimulus trait VT:0010716 anxiety-related behavior trait MP:0001362 abnormal anxiety-related response MP:0001392 abnormal locomotor behavior MP:0009745 abnormal behavioral response to xenobiotic

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Thomsen2 - total activity, dose response to D1 agonist, 3h test

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between sex	1	59253.7922	59253.7922	0.0136	0.9072
between strain	8	818269983.686	102283747.9608	23.5513	< 0.0001
between sex:strain	8	164806700.1467	20600837.5183	4.7434	< 0.0001
between Residuals	114	495105128.3024	4343027.4412
within dose	4	563167255.6515	140791813.9129	74.0132	< 0.0001
within dose:sex	4	30956292.7275	7739073.1819	4.0684	0.003
within dose:strain	32	851168605.2884	26599018.9153	13.9829	< 0.0001
within dose:sex:strain	32	164164035.3564	5130126.1049	2.6969	< 0.0001
within Residuals	456	867427205.7762	1902252.6442

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Thomsen2	40801	open field test	R-6-Br-APB	total activity, dose response to D1 agonist, 3h test [n] baseline activ_D1_0	inbred	15	both	8-10wks
Thomsen2	40802	open field test	R-6-Br-APB	total activity, dose response to D1 agonist, 3h test [n] dose 0.03 mg/kg activ_D1_doseA	inbred	15	both	8-10wks
Thomsen2	40803	open field test	R-6-Br-APB	total activity, dose response to D1 agonist, 3h test [n] dose 0.32 mg/kg activ_D1_doseB	inbred	15	both	8-10wks
Thomsen2	40804	open field test	R-6-Br-APB	total activity, dose response to D1 agonist, 3h test [n] dose 3.2 mg/kg activ_D1_doseC	inbred	15	both	8-10wks
Thomsen2	40805	open field test	R-6-Br-APB	total activity, dose response to D1 agonist, 3h test [n] dose 5.6 mg/kg activ_D1_doseD	inbred	11	both	8-10wks