MPD: Project measures / variables set: Thomsen1 activ

Project measures / variables set: Thomsen1 activ_cocaine1

ID, description, units	MPD:40701 activ_cocaine1 total activity, test 1, 3h test [n] cocaine study
Measures	• baseline • dose mg/kg i.p.: • 3 • 10 • 18 • 32 • 56
Data set, strains	Thomsen1 inbred 15 strains sex: both age: 8-10wks
Procedure	open field test
Comparison	repeated measures, baseline then treated multiple doses, same cohort
Ontology mappings	VT:0001392 locomotor behavior trait VT:0010716 anxiety-related behavior trait VT:0010718 response to cocaine trait MP:0001362 abnormal anxiety-related response MP:0001392 abnormal locomotor behavior MP:0020158 abnormal behavioral response to cocaine

Values Means Δ Means Z-scores

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Thomsen1 - total activity, test 1, 3h test

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between sex	1	32045417.2296	32045417.2296	1.9355	0.1657
between strain	14	8140108168.5364	581436297.7526	35.1173	< 0.0001
between sex:strain	14	479106079.6154	34221862.8297	2.0669	0.0151
between Residuals	196	3245169963.2321	16556989.6083
within dose	5	1406071506.8289	281214301.3658	106.5444	< 0.0001
within dose:sex	5	18595789.2005	3719157.8401	1.4091	0.2183
within dose:strain	70	772634369.3456	11037633.8478	4.1819	< 0.0001
within dose:sex:strain	70	352407852.738	5034397.8963	1.9074	< 0.0001
within Residuals	980	2586622294.5536	2639410.5046

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Thomsen1	40701	open field test	cocaine	total activity, test 1, 3h test [n] baseline activ_cocaine1_0	inbred	15	both	8-10wks
Thomsen1	40702	open field test	cocaine	total activity, test 1, 3h test [n] dose 3 mg/kg activ_cocaine1_3	inbred	15	both	8-10wks
Thomsen1	40703	open field test	cocaine	total activity, test 1, 3h test [n] dose 10 mg/kg activ_cocaine1_10	inbred	15	both	8-10wks
Thomsen1	40704	open field test	cocaine	total activity, test 1, 3h test [n] dose 18 mg/kg activ_cocaine1_18	inbred	15	both	8-10wks
Thomsen1	40705	open field test	cocaine	total activity, test 1, 3h test [n] dose 32 mg/kg activ_cocaine1_32	inbred	15	both	8-10wks
Thomsen1	40706	open field test	cocaine	total activity, test 1, 3h test [n] dose 56 mg/kg activ_cocaine1_56	inbred	15	both	8-10wks