MPD: Project measures / variables set: Yuan3 T4

Project measures / variables set: Yuan3 T4

ID, description, units	MPD:24476 T4 thyroxine (serum T4) [µg/dL]
Measures	• 6mo • 12mo • 18mo
Data set, strains	Yuan3 inbred 32 strains sex: both
Procedure	metabolic panel
Comparison	timecourse, same cohort (aging study)
Ontology mappings	VT:0005475 blood thyroxine amount MA:0002502 serum MP:0005475 abnormal circulating thyroxine level

Values Means Δ Means Z-scores

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Yuan3 - thyroxine (serum T4)

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between sex	1	39.9618	39.9618	41.1662	< 0.0001
between strain	1	14.8673	14.8673	15.3153	0.0008
between sex:strain	1	11.0115	11.0115	11.3433	0.0029
between Residuals	21	20.3856	0.9707
within age	2	14.9579	7.4789	15.3766	< 0.0001
within age:sex	2	0.1008	0.0504	0.1036	0.9018
within age:strain	2	14.2554	7.1277	14.6544	< 0.0001
within age:sex:strain	2	1.4912	0.7456	1.5329	0.2277
within Residuals	42	20.4281	0.4864

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Yuan3	24476	metabolic panel	(none)	thyroxine (serum T4) [µg/dL] at age 6mo T4_M06	inbred	30	both	26wks
Yuan3	24477	metabolic panel	(none)	thyroxine (serum T4) [µg/dL] at age 12mo T4_M12	inbred	31	both	52wks
Yuan3	24478	metabolic panel	(none)	thyroxine (serum T4) [µg/dL] at age 18mo T4_M18	inbred	29	both	78wks