MPD: Project measures / variables set: Threadgill1 CYP2E1

Project measures / variables set: Threadgill1 CYP2E1

ID, description, units	MPD:19484 CYP2E1 cytochrome P450 2E1 isoform [pmol/mg] acetaminophen study
Measures	• control • post-Rx 300 mg/kg
Data set, strains	Threadgill1 inbred w/CC7 37 strains sex: m age: 8-12wks
Procedure	biomarker quantification
Comparison	control group vs. treated group
Ontology mappings	VT:0000609 liver physiology trait VT:0010487 response to xenobiotic stimulus trait MA:0000358 liver MP:0008469 abnormal protein level MP:0008872 abnormal physiological response to xenobiotic

Values Means Δ Means Z-scores

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Threadgill1 - cytochrome P450 2E1 isoform

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
group	1	45451.2021	45451.2021	13.5471	0.0004
strain	27	97397.6541	3607.3205	1.0752	0.3843
group:strain	27	38882.9567	1440.1095	0.4292	0.993
Residuals	97	325440.8802	3355.0606

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Threadgill1	19484	biomarker quantification	acetaminophen	cytochrome P450 2E1 isoform [pmol/mg] control CYP2E1_ctrl	inbred w/CC7	37	m	8-12wks
Threadgill1	19489	biomarker quantification	acetaminophen	cytochrome P450 2E1 isoform [pmol/mg] post-Rx 300 mg/kg CYP2E1_Rx300	inbred w/CC7	37	m	8-12wks