MPD: Project measures / variables set: Xenakis1 latency

Project measures / variables set: Xenakis1 latency_Rx

ID, description, units	MPD:111156 latency_Rx latency to move all four paws (extrapyramidal symptoms), treatment group [s] haloperidol study
Measures	• pre-treatment • post-treatment
Data set, strains	Xenakis1 CC RIX 73 strains sex: both age: 7-9wks
Procedure	inclined screen test
Comparison	control group vs. treated group
Ontology mappings	VT:0001392 locomotor behavior trait VT:0001516 motor coordination/balance trait VT:0002121 metabolism trait VT:0003492 involuntary movement trait VT:0010487 response to xenobiotic stimulus trait MP:0001392 abnormal locomotor behavior MP:0001516 abnormal motor coordination/balance MP:0003492 abnormal involuntary movement MP:0012693 abnormal haloperidol metabolism

Values Means Δ Means Z-scores

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Xenakis1 - latency to move all four paws (extrapyramidal symptoms), treatment group

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
group	1	43145.911	43145.911	236.2283	< 0.0001
sex	1	124.5597	124.5597	0.682	0.4096
strain	36	29770.3298	826.9536	4.5277	< 0.0001
group:sex	1	102.2504	102.2504	0.5598	0.455
group:strain	36	21703.1942	602.8665	3.3008	< 0.0001
sex:strain	36	7347.2053	204.089	1.1174	0.3042
group:sex:strain	36	9677.3466	268.8152	1.4718	0.0465
Residuals	275	50227.36	182.6449

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Xenakis1	111156	inclined screen test	haloperidol	latency to move all four paws (extrapyramidal symptoms), treatment group [s] pre-treatment latency_Rx_pre	CC RIX	72	both	7-9wks
Xenakis1	111157	inclined screen test	haloperidol	latency to move all four paws (extrapyramidal symptoms), treatment group [s] post-treatment latency_Rx_post	CC RIX	70	both	7-9wks