Project measure / variable:   CSNA03   dist_d3_d11_auc_cocaine_in

ID, description, units MPD:90440   dist_d3_d11_auc_cocaine_in   distance traveled, last 60 min (post-injection), Day 3 (cocaine) to Day 11 (cocaine) AUC, cocaine sensitization, founders    
cocaine study
Data set, strains CSNA03   inbred w/CC8   10 strains     sex: both     age: 8-14wks
Procedure open field test
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  STRAIN COMPARISON PLOT
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CSNA03 - distance traveled, last 60 min (post-injection), Day 3 (cocaine) to Day 11 (cocaine) AUC, cocaine sensitization, founders



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means165920.0   None 161964.0   None
Median of the strain means130592.0   None 195488.0   None
SD of the strain means± 123200.0 ± 112267.0
Coefficient of variation (CV)0.7425 0.6932
Min–max range of strain means20635.0   –   353588.0   None 19898.0   –   314526.0   None
Mean sample size per strain5.7   mice 6.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 9175964597.9082 9175964597.9082 1.9356 0.1672
strain 8 1626317768524.6716 203289721065.584 42.8826 < 0.0001
sex:strain 8 74632806039.424 9329100754.928 1.9679 0.0581
Residuals 101 478801387351.2672 4740607795.5571


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 52027.0 124071.0   6 50652.0 2.3847 -0.92
129S1/SvImJ m 19898.0 19568.0   6 7989.0 0.9835 2749.0, 52297.0 -1.27
A/J f 20635.0 12103.0   11 3649.0 0.5865 4334.0, 38769.0 -1.18
A/J m 24299.0 22446.0   12 6480.0 0.9238 3129.0, 85285.0 -1.23
C57BL/6J f 127391.0 12478.0   4 6239.0 0.0979 113104.0, 143527.0 -0.31
C57BL/6J m 152955.0 52922.0   7 20003.0 0.346 80072.0, 221508.0 -0.08
C57BL/6NJ f 60961.0 0.0   1   0.0 0.0 60961.0, 60961.0 -0.85
C57BL/6NJ m 55360.0 0.0   1   0.0 0.0 55360.0, 55360.0 -0.95
CAST/EiJ f 330854.0 114097.0   6 46580.0 0.3449 219795.0, 499672.0 1.34
CAST/EiJ m 268513.0 91452.0   5 40899.0 0.3406 146860.0, 383331.0 0.95
DBA/2J f 133792.0 5641.0   2   3988.0 0.0422 129803.0, 137780.0 -0.26
DBA/2J m 238021.0 67842.0   4 33921.0 0.285 143618.0, 289663.0 0.68
NOD/ShiLtJ f 222592.0 66985.0   6 27347.0 0.3009 139095.0, 304487.0 0.46
NOD/ShiLtJ m 239615.0 88130.0   6 35979.0 0.3678 112667.0, 339006.0 0.69
NZO/HlLtJ f 71368.0 30963.0   5 13847.0 0.4338 41586.0, 110600.0 -0.77
NZO/HlLtJ m 63057.0 30310.0   7 11456.0 0.4807 27941.0, 112161.0 -0.88
PWK/PhJ f 285992.0 43181.0   9 14394.0 0.151 234836.0, 353765.0 0.97
PWK/PhJ m 314526.0 88481.0   9 29494.0 0.2813 200266.0, 468118.0 1.36
WSB/EiJ f 353588.0 118553.0   7 44809.0 0.3353 207780.0, 564783.0 1.52
WSB/EiJ m 243392.0 71604.0   7 27064.0 0.2942 121817.0, 335425.0 0.73


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 52027.0383333327 28108.7406203038 107787.2185558669 -3733.1418892015
129S1/SvImJ m 19897.4999999999 28108.7406203038 75657.6802225341 -35862.6802225343
A/J f 20634.7272727273 20759.6807550272 61816.3495979356 -20546.8950524809
A/J m 24298.8333333334 19875.8811032306 63727.2348888713 -15129.5682222046
C57BL/6J f 127391.0 34426.0359159935 195682.9947554195 59099.0052445805
C57BL/6J m 152954.5714285714 26023.6370455704 204578.4670455335 101330.6758116093
CAST/EiJ f 330853.8333333342 28108.7406203038 386614.0135558685 275093.6531107999
CAST/EiJ m 268513.4000000007 30791.5826016043 329595.6170368716 207431.1829631298
DBA/2J f 133791.5 48685.7668911413 230370.9651846266 37212.0348153733
DBA/2J m 238020.75 34426.0359159935 306312.7447554196 169728.7552445805
NOD/ShiLtJ f 222592.5000000003 28108.7406203038 278352.6802225347 166832.319777466
NOD/ShiLtJ m 239614.8333333338 28108.7406203038 295375.0135558679 183854.6531107996
NZO/HlLtJ f 71368.3999999999 30791.5826016044 132450.6170368709 10286.1829631289
NZO/HlLtJ m 63056.9999999999 26023.6370455704 114680.8956169619 11433.1043830379
PWK/PhJ f 285992.1111111112 22950.6906106624 331520.1076147242 240464.1146074982
PWK/PhJ m 314526.0 22950.6906106623 360053.996503613 268998.003496387
WSB/EiJ f 353588.4285714286 26023.6370455704 405212.3241883907 301964.5329544665
WSB/EiJ m 243392.1428571429 26023.6370455704 295016.0384741049 191768.2472401808


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 35962.2691666663 19875.8811032306 75390.6707222043 -3466.1323888717
A/J both 22466.7803030303 14370.2382955225 50973.4675297182 -6039.9069236575
C57BL/6J both 140172.7857142857 21577.6599401375 182977.0587087697 97368.5127198017
CAST/EiJ both 299683.6166666675 20845.9999662462 341036.4730873215 258330.7602460134
DBA/2J both 185906.125 29813.8216548459 245048.727333307 126763.522666693
NOD/ShiLtJ both 231103.6666666671 19875.8811032306 270532.068222205 191675.2651111291
NZO/HlLtJ both 67212.6999999999 20157.8225770482 107200.3975981688 27225.002401831
PWK/PhJ both 300259.0555555556 16228.5889637138 332452.2106170979 268065.9004940134
WSB/EiJ both 298490.2857142857 18401.4902260603 334993.8923763061 261986.6790522654




  GWAS USING LINEAR MIXED MODELS