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Project measure / variable:   GMC12   LV_mass

ID, description, units MPD:56121   LV_mass   left ventricular mass corrected   [mg]  
Data set, strains GMC12   inbred w/CC8   8 strains     sex: both     age: 14-15wks
Procedure echocardiography
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  STRAIN COMPARISON PLOT
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GMC12 - left ventricular mass corrected



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means19.6   mg 22.2   mg
Median of the strain means16.5   mg 20.0   mg
SD of the strain means± 7.61 ± 8.01
Coefficient of variation (CV)0.387 0.362
Min–max range of strain means13.3   –   31.0   mg 13.9   –   37.1   mg
Mean sample size per strain17.1   mice 16.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 537.068 537.068 11.9121 0.0007
strain 7 14449.5127 2064.2161 45.784 < 0.0001
sex:strain 7 273.27 39.0386 0.8659 0.5341
Residuals 252 11361.6767 45.086


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 14.2 4.16   16 1.04 0.292 8.37, 19.9 -0.71
129S1/SvImJ m 19.2 8.06   16 2.02 0.42 9.63, 36.0 -0.37
A/J f 13.7 2.84   15 0.733 0.207 7.44, 18.0 -0.78
A/J m 16.6 4.6   16 1.15 0.277 8.78, 29.6 -0.69
C57BL/6J f 21.8 7.88   16 1.97 0.362 11.9, 35.5 0.28
C57BL/6J m 22.7 8.28   16 2.07 0.365 15.7, 50.2 0.07
CAST/EiJ f 13.4 4.6   19 1.05 0.343 7.31, 25.2 -0.82
CAST/EiJ m 16.0 2.96   14 0.791 0.185 11.0, 21.7 -0.77
NOD/ShiLtJ f 18.8 3.49   18 0.822 0.186 11.9, 23.5 -0.11
NOD/ShiLtJ m 20.8 3.92   16 0.98 0.189 14.9, 28.9 -0.17
NZO/HlLtJ f 30.9 8.72   17 2.11 0.282 20.9, 48.2 1.48
NZO/HlLtJ m 37.1 7.89   17 1.91 0.213 25.1, 49.6 1.86
PWK/PhJ f 31.0 9.93   19 2.28 0.321 14.5, 52.1 1.49
PWK/PhJ m 31.0 10.8   20 2.4 0.347 17.9, 60.9 1.1
WSB/EiJ f 13.3 5.88   17 1.43 0.441 7.2, 29.3 -0.83
WSB/EiJ m 13.9 2.12   16 0.53 0.153 11.0, 18.7 -1.03


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 14.2431 1.6787 17.5491 10.9371
129S1/SvImJ m 19.1794 1.6787 22.4854 15.8734
A/J f 13.6987 1.7337 17.1131 10.2843
A/J m 16.6262 1.6787 19.9322 13.3203
C57BL/6J f 21.7881 1.6787 25.0941 18.4821
C57BL/6J m 22.7231 1.6787 26.0291 19.4171
CAST/EiJ f 13.3953 1.5404 16.429 10.3615
CAST/EiJ m 16.0114 1.7946 19.5457 12.4772
NOD/ShiLtJ f 18.7567 1.5826 21.8736 15.6398
NOD/ShiLtJ m 20.7875 1.6787 24.0935 17.4815
NZO/HlLtJ f 30.9306 1.6285 34.1379 27.7233
NZO/HlLtJ m 37.1012 1.6285 40.3084 33.8939
PWK/PhJ f 30.9547 1.5404 33.9885 27.921
PWK/PhJ m 31.0315 1.5014 33.9885 28.0745
WSB/EiJ f 13.3365 1.6285 16.5437 10.1292
WSB/EiJ m 13.8944 1.6787 17.2004 10.5884


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 16.7112 1.187 19.0489 14.3736
A/J both 15.1625 1.2066 17.5388 12.7861
C57BL/6J both 22.2556 1.187 24.5933 19.9179
CAST/EiJ both 14.7033 1.1825 17.0322 12.3745
NOD/ShiLtJ both 19.7721 1.1535 22.0439 17.5003
NZO/HlLtJ both 34.0159 1.1515 36.2838 31.748
PWK/PhJ both 30.9931 1.0756 33.1113 28.8749
WSB/EiJ both 13.6154 1.1694 15.9185 11.3124




  GWAS USING LINEAR MIXED MODELS