Project measure / variable:   GMC07   latency_1

ID, description, units MPD:55611   latency_1   latency of nociceptive response to hot plate   [s]  reaction1  
Data set, strains GMC07   inbred w/CC8   8 strains     sex: both     age: 11-12wks
Procedure nociception assay
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  STRAIN COMPARISON PLOT
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GMC07 - latency of nociceptive response to hot plate reaction1



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means15.9   s 16.8   s
Median of the strain means13.3   s 15.9   s
SD of the strain means± 4.89 ± 7.62
Coefficient of variation (CV)0.309 0.453
Min–max range of strain means11.7   –   24.7   s 9.78   –   34.2   s
Mean sample size per strain17.5   mice 16.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 58.4286 58.4286 0.1831 0.6691
strain 7 4892.6554 698.9508 2.1899 0.0355
sex:strain 7 4617.2915 659.6131 2.0667 0.0475
Residuals 259 82663.9744 319.1659


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 21.0 6.97   16 1.74 0.332 8.3, 30.0 1.05
129S1/SvImJ m 17.9 7.12   16 1.78 0.399 6.9, 30.0 0.14
A/J f 18.4 9.02   16 2.25 0.489 4.4, 30.0 0.52
A/J m 16.0 8.82   16 2.2 0.551 4.2, 30.0 -0.11
C57BL/6J f 11.7 3.38   16 0.844 0.288 3.7, 15.9 -0.85
C57BL/6J m 13.4 5.27   16 1.32 0.394 5.6, 22.3 -0.45
CAST/EiJ f 12.5 2.98   19 0.683 0.238 8.9, 17.9 -0.69
CAST/EiJ m 10.5 4.0   17 0.97 0.38 4.4, 18.1 -0.83
NOD/ShiLtJ f 24.7 33.7   18 7.95 1.37 11.1, 158.0 1.81
NOD/ShiLtJ m 15.9 4.59   16 1.15 0.289 8.5, 24.0 -0.12
NZO/HlLtJ f 12.0 4.84   17 1.17 0.403 7.5, 23.2 -0.79
NZO/HlLtJ m 9.78 2.83   17 0.686 0.289 5.4, 16.4 -0.92
PWK/PhJ f 13.2 5.25   20 1.17 0.399 2.4, 29.4 -0.54
PWK/PhJ m 16.8 8.56   21 1.87 0.51 5.9, 30.0 0.0
WSB/EiJ f 13.4 6.98   18 1.65 0.522 6.8, 30.0 -0.5
WSB/EiJ m 34.2 60.4   16 15.1 1.77 5.7, 259.0 2.28


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 21.0125 4.4663 29.8074 12.2176
129S1/SvImJ m 17.8625 4.4663 26.6574 9.0676
A/J f 18.4437 4.4663 27.2386 9.6489
A/J m 15.9875 4.4663 24.7824 7.1926
C57BL/6J f 11.7125 4.4663 20.5074 2.9176
C57BL/6J m 13.3687 4.4663 22.1636 4.5739
CAST/EiJ f 12.4895 4.0986 20.5602 4.4187
CAST/EiJ m 10.5176 4.333 19.0499 1.9853
NOD/ShiLtJ f 24.6889 4.2109 32.9808 16.397
NOD/ShiLtJ m 15.8687 4.4663 24.6636 7.0739
NZO/HlLtJ f 12.0118 4.333 20.5441 3.4795
NZO/HlLtJ m 9.7765 4.333 18.3088 1.2442
PWK/PhJ f 13.155 3.9948 21.0214 5.2886
PWK/PhJ m 16.7952 3.8985 24.472 9.1184
WSB/EiJ f 13.3778 4.2109 21.6697 5.0859
WSB/EiJ m 34.1875 4.4663 42.9824 25.3926


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 19.4375 3.1582 25.6564 13.2186
A/J both 17.2156 3.1582 23.4346 10.9967
C57BL/6J both 12.5406 3.1582 18.7596 6.3217
CAST/EiJ both 11.5036 2.9821 17.3759 5.6312
NOD/ShiLtJ both 20.2788 3.0692 26.3225 14.2351
NZO/HlLtJ both 10.8941 3.0639 16.9274 4.8609
PWK/PhJ both 14.9751 2.7909 20.4709 9.4794
WSB/EiJ both 23.7826 3.0692 29.8264 17.7389




  GWAS USING LINEAR MIXED MODELS