Project measure / variable:   GMC06   CHOL

ID, description, units MPD:55521   CHOL   total cholesterol (plasma CHOL, 16h fast)   [mmol/L]  
Data set, strains GMC06   inbred   5 strains     sex: both     age: 10-11wks
Procedure lipid profile
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  STRAIN COMPARISON PLOT
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GMC06 - total cholesterol (plasma CHOL, 16h fast)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested5 strains5 strains
Mean of the strain means2.91   mmol/L 3.63   mmol/L
Median of the strain means2.25   mmol/L 2.84   mmol/L
SD of the strain means± 1.34 ± 1.74
Coefficient of variation (CV)0.461 0.480
Min–max range of strain means1.76   –   5.00   mmol/L 2.11   –   6.50   mmol/L
Mean sample size per strain16.6   mice 16.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 21.101 21.101 111.7112 < 0.0001
strain 4 307.5248 76.8812 407.0182 < 0.0001
sex:strain 4 7.0716 1.7679 9.3595 < 0.0001
Residuals 153 28.9 0.1889


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 3.47 0.25   16 0.0625 0.072 3.06, 3.95 0.42
129S1/SvImJ m 4.0 0.489   16 0.122 0.122 3.29, 5.14 0.21
A/J f 1.76 0.198   16 0.0496 0.112 1.29, 2.09 -0.86
A/J m 2.11 0.176   16 0.0441 0.0834 1.79, 2.45 -0.87
C57BL/6J f 2.25 0.153   16 0.0382 0.0677 1.93, 2.56 -0.49
C57BL/6J m 2.71 0.275   16 0.0688 0.101 2.03, 3.06 -0.53
NOD/ShiLtJ f 2.05 0.337   18 0.0795 0.165 1.45, 2.63 -0.64
NOD/ShiLtJ m 2.84 0.186   16 0.0464 0.0654 2.47, 3.13 -0.45
NZO/HlLtJ f 5.0 0.455   17 0.11 0.0911 4.11, 5.95 1.56
NZO/HlLtJ m 6.5 1.04   16 0.259 0.159 4.56, 7.91 1.65


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 3.4727 0.1087 3.6874 3.2581
129S1/SvImJ m 3.9968 0.1087 4.2115 3.7822
A/J f 1.7649 0.1087 1.9796 1.5503
A/J m 2.113 0.1087 2.3277 1.8983
C57BL/6J f 2.255 0.1087 2.4697 2.0403
C57BL/6J m 2.7139 0.1087 2.9285 2.4992
NOD/ShiLtJ f 2.0507 0.1024 2.2531 1.8483
NOD/ShiLtJ m 2.8358 0.1087 3.0504 2.6211
NZO/HlLtJ f 4.9962 0.1054 5.2045 4.788
NZO/HlLtJ m 6.5013 0.1087 6.716 6.2867


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 3.7348 0.0768 3.8866 3.583
A/J both 1.939 0.0768 2.0908 1.7872
C57BL/6J both 2.4844 0.0768 2.6362 2.3327
NOD/ShiLtJ both 2.4432 0.0747 2.5907 2.2957
NZO/HlLtJ both 5.7488 0.0757 5.8983 5.5992




  GWAS USING LINEAR MIXED MODELS