Project measure / variable:   GMC05   PPI_73

ID, description, units MPD:55433   PPI_73   percent prepulse inhibition (PPI), 110 db sound pressure level   [%]  with 73 dB prepulse stimulus  
Data set, strains GMC05   inbred w/CC8   8 strains     sex: both     age: 9-10wks
Procedure acoustic startle test
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  STRAIN COMPARISON PLOT
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GMC05 - percent prepulse inhibition (PPI), 110 db sound pressure level with 73 dB prepulse stimulus



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means37.8   % 38.3   %
Median of the strain means43.5   % 36.5   %
SD of the strain means± 29.8 ± 22.4
Coefficient of variation (CV)0.789 0.586
Min–max range of strain means-20.6   –   81.5   % 3.22   –   73.6   %
Mean sample size per strain17.5   mice 17.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 1.4498 1.4498 0.0022 0.963
strain 7 146279.8008 20897.1144 31.1216 < 0.0001
sex:strain 7 11864.6475 1694.9496 2.5242 0.0158
Residuals 261 175252.815 671.4667


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 81.5 10.6   16 2.65 0.13 58.6, 92.6 1.46
129S1/SvImJ m 73.6 11.4   16 2.84 0.154 50.8, 86.6 1.57
A/J f -20.6 60.8   16 15.2 -2.95 -182.0, 44.2 -1.96
A/J m 3.22 32.7   16 8.18 10.2 -85.3, 49.6 -1.56
C57BL/6J f 53.0 13.7   16 3.42 0.258 19.8, 77.8 0.51
C57BL/6J m 58.6 11.5   16 2.89 0.197 42.8, 79.8 0.91
CAST/EiJ f 48.8 14.2   19 3.26 0.291 12.0, 64.4 0.37
CAST/EiJ m 49.1 18.7   18 4.41 0.381 7.8, 74.4 0.48
NOD/ShiLtJ f 49.6 17.1   18 4.02 0.344 17.8, 74.4 0.39
NOD/ShiLtJ m 26.2 30.9   16 7.73 1.18 -19.4, 67.8 -0.54
NZO/HlLtJ f 17.5 24.3   17 5.89 1.38 -15.0, 49.6 -0.68
NZO/HlLtJ m 22.7 26.9   17 6.53 1.18 -7.1, 56.5 -0.7
PWK/PhJ f 38.3 26.5   20 5.92 0.691 -33.0, 67.9 0.02
PWK/PhJ m 28.8 14.3   22 3.04 0.496 2.9, 51.6 -0.42
WSB/EiJ f 34.6 31.9   18 7.53 0.924 -42.3, 63.3 -0.11
WSB/EiJ m 44.1 26.4   16 6.61 0.6 -13.9, 71.5 0.26


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 81.525 6.4782 94.2811 68.7689
129S1/SvImJ m 73.5938 6.4782 86.3499 60.8376
A/J f -20.6125 6.4782 -7.8564 -33.3686
A/J m 3.2188 6.4782 15.9749 -9.5374
C57BL/6J f 53.025 6.4782 65.7811 40.2689
C57BL/6J m 58.6438 6.4782 71.3999 45.8876
CAST/EiJ f 48.7737 5.9448 60.4795 37.0679
CAST/EiJ m 49.0833 6.1077 61.1099 37.0567
NOD/ShiLtJ f 49.5611 6.1077 61.5877 37.5345
NOD/ShiLtJ m 26.2125 6.4782 38.9686 13.4564
NZO/HlLtJ f 17.5353 6.2847 29.9106 5.16
NZO/HlLtJ m 22.7294 6.2847 35.1047 10.3541
PWK/PhJ f 38.3 5.7943 49.7094 26.8906
PWK/PhJ m 28.7545 5.5246 39.633 17.8761
WSB/EiJ f 34.5722 6.1077 46.5988 22.5456
WSB/EiJ m 44.0625 6.4782 56.8186 31.3064


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 77.5594 4.5808 86.5793 68.5394
A/J both -8.6969 4.5808 0.3231 -17.7168
C57BL/6J both 55.8344 4.5808 64.8543 46.8144
CAST/EiJ both 48.9285 4.2616 57.32 40.5371
NOD/ShiLtJ both 37.8868 4.4517 46.6526 29.121
NZO/HlLtJ both 20.1324 4.444 28.883 11.3817
PWK/PhJ both 33.5273 4.003 41.4095 25.6451
WSB/EiJ both 39.3174 4.4517 48.0832 30.5516




  GWAS USING LINEAR MIXED MODELS