Project measure / variable:   GMC05   ASR_PP_73

ID, description, units MPD:55423   ASR_PP_73   acoustic startle response (ASR), 110 db sound pressure level   [amplitude]  with 73 dB prepulse stimulus  
Data set, strains GMC05   inbred w/CC8   8 strains     sex: both     age: 9-10wks
Procedure acoustic startle test
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  STRAIN COMPARISON PLOT
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GMC05 - acoustic startle response (ASR), 110 db sound pressure level with 73 dB prepulse stimulus



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means479   amplitude 555   amplitude
Median of the strain means245   amplitude 344   amplitude
SD of the strain means± 642 ± 617
Coefficient of variation (CV)1.34 1.11
Min–max range of strain means141   –   2059   amplitude 201   –   2059   amplitude
Mean sample size per strain17.5   mice 17.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 427565.411 427565.411 4.1175 0.0435
strain 7 94268104.9009 13466872.1287 129.687 < 0.0001
sex:strain 7 592963.9738 84709.1391 0.8158 0.5749
Residuals 261 27102591.2924 103841.3459


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 235.0 143.0   16 35.8 0.609 123.0, 627.0 -0.38
129S1/SvImJ m 467.0 225.0   16 56.2 0.481 230.0, 994.0 -0.14
A/J f 238.0 184.0   16 46.0 0.773 43.6, 796.0 -0.38
A/J m 224.0 89.7   16 22.4 0.4 86.8, 421.0 -0.54
C57BL/6J f 286.0 164.0   16 41.0 0.574 117.0, 670.0 -0.3
C57BL/6J m 514.0 191.0   16 47.8 0.372 235.0, 921.0 -0.07
CAST/EiJ f 224.0 83.9   19 19.3 0.375 139.0, 457.0 -0.4
CAST/EiJ m 310.0 130.0   18 30.6 0.419 129.0, 654.0 -0.4
NOD/ShiLtJ f 141.0 66.2   18 15.6 0.471 74.3, 308.0 -0.53
NOD/ShiLtJ m 201.0 130.0   16 32.4 0.645 90.6, 620.0 -0.57
NZO/HlLtJ f 2059.0 791.0   17 192.0 0.384 946.0, 3304.0 2.46
NZO/HlLtJ m 2059.0 885.0   17 215.0 0.43 540.0, 3404.0 2.44
PWK/PhJ f 252.0 60.3   20 13.5 0.239 177.0, 399.0 -0.35
PWK/PhJ m 289.0 82.6   22 17.6 0.286 164.0, 528.0 -0.43
WSB/EiJ f 397.0 215.0   18 50.6 0.541 221.0, 1052.0 -0.13
WSB/EiJ m 377.0 108.0   16 27.1 0.287 231.0, 617.0 -0.29


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 234.9813 80.5611 393.6136 76.3489
129S1/SvImJ m 467.1812 80.5611 625.8136 308.5489
A/J f 237.825 80.5611 396.4574 79.1926
A/J m 224.0062 80.5611 382.6386 65.3739
C57BL/6J f 286.075 80.5611 444.7074 127.4426
C57BL/6J m 514.4125 80.5611 673.0449 355.7801
CAST/EiJ f 223.5158 73.9279 369.0868 77.9448
CAST/EiJ m 310.3333 75.9537 459.8934 160.7733
NOD/ShiLtJ f 140.6278 75.9537 290.1878 -8.9322
NOD/ShiLtJ m 200.8437 80.5611 359.4761 42.2114
NZO/HlLtJ f 2059.2824 78.1557 2213.1783 1905.3864
NZO/HlLtJ m 2058.5235 78.1557 2212.4195 1904.6275
PWK/PhJ f 252.015 72.056 393.9001 110.1299
PWK/PhJ m 288.7182 68.7027 424.0003 153.4361
WSB/EiJ f 397.1167 75.9537 546.6767 247.5566
WSB/EiJ m 376.8375 80.5611 535.4699 218.2051


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 351.0813 56.9653 463.2513 238.9112
A/J both 230.9156 56.9653 343.0856 118.7456
C57BL/6J both 400.2438 56.9653 512.4138 288.0737
CAST/EiJ both 266.9246 52.996 371.2787 162.5704
NOD/ShiLtJ both 170.7358 55.3603 279.7454 61.7261
NZO/HlLtJ both 2058.9029 55.2644 2167.7238 1950.082
PWK/PhJ both 270.3666 49.7798 368.3878 172.3454
WSB/EiJ both 386.9771 55.3603 495.9867 277.9674




  GWAS USING LINEAR MIXED MODELS