Project measure / variable:   Wiltshire4   Bcells_Sel_E

ID, description, units MPD:52466   Bcells_Sel_E   B cells, percent viability   [%]  dose: 100 µM  
selumetinib study
Data set, strains Wiltshire4   inbred w/CC7   34 strains     sex: m     age: 10wks
Procedure immune cell quantification
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  STRAIN COMPARISON PLOT
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Wiltshire4 - B cells, percent viability dose: 100 µM



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested34 strains
Mean of the strain means88.8   %
Median of the strain means94.8   %
SD of the strain means± 20.0
Coefficient of variation (CV)0.225
Min–max range of strain means28.8   –   116   %
Mean sample size per strain4.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 33 52449.9753 1589.3932 2.6943 0.0001
Residuals 99 58401.1219 589.9103


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 102.0 6.78   4 3.39 0.0662 96.2, 110.0 0.66
129X1/SvJ m 93.6 13.8   4 6.9 0.148 80.7, 113.0 0.24
A/J m 91.1 17.1   4 8.57 0.188 74.3, 113.0 0.11
AKR/J m 104.0 6.46   4 3.23 0.062 94.6, 108.0 0.76
BALB/cByJ m 101.0 1.25   4 0.624 0.0124 99.3, 102.0 0.61
BTBR T+ Itpr3tf/J m 48.5 20.9   4 10.4 0.43 32.5, 78.4 -2.01
BUB/BnJ m 109.0 16.4   4 8.21 0.151 90.6, 125.0 1.01
C3H/HeJ m 88.1 7.45   4 3.73 0.0846 79.5, 96.2 -0.04
C57BL/6J m 96.0 5.68   4 2.84 0.0592 91.0, 103.0 0.36
C57BLKS/J m 69.3 18.8   4 9.4 0.271 46.6, 92.4 -0.97
C58/J m 79.7 9.06   2   6.41 0.114 73.3, 86.1 -0.46
CBA/J m 67.5 23.5   4 11.8 0.348 49.6, 102.0 -1.06
CZECHII/EiJ m 114.0 18.8   4 9.38 0.165 87.7, 128.0 1.26
DBA/2J m 63.6 30.4   4 15.2 0.477 24.5, 98.1 -1.26
FVB/NJ m 112.0 7.02   4 3.51 0.0626 105.0, 118.0 1.16
I/LnJ m 100.0 24.8   4 12.4 0.247 64.4, 119.0 0.56
KK/HlJ m 89.9 8.56   4 4.28 0.0952 77.4, 95.6 0.05
LG/J m 110.0 31.6   4 15.8 0.288 66.7, 133.0 1.06
LP/J m 102.0 11.5   4 5.75 0.113 90.5, 115.0 0.66
MA/MyJ m 81.5 6.76   4 3.38 0.083 75.3, 87.7 -0.37
NOD/ShiLtJ m 74.2 9.64   4 4.82 0.13 61.9, 84.4 -0.73
NON/ShiLtJ m 79.6 8.41   4 4.2 0.106 71.6, 89.8 -0.46
NZB/BlNJ m 97.4 3.39   4 1.7 0.0349 93.5, 101.0 0.43
NZO/HlLtJ m 28.8 21.3   4 10.6 0.74 -3.0
NZW/LacJ m 68.2 14.7   4 7.37 0.216 52.7, 87.9 -1.03
PERA/EiJ m 87.7 14.4   4 7.22 0.165 77.5, 109.0 -0.06
PL/J m 97.8 9.73   4 4.87 0.0995 85.8, 109.0 0.45
PWD/PhJ m 116.0 110.0   4 55.0 0.949 1.36
PWK/PhJ m 102.0 7.29   4 3.65 0.0718 92.3, 110.0 0.66
RIIIS/J m 99.6 5.45   4 2.72 0.0547 92.0, 105.0 0.54
SEA/GnJ m 87.2 11.5   4 5.77 0.132 71.7, 96.2 -0.08
SJL/J m 54.5 10.5   4 5.27 0.194 41.2, 63.0 -1.71
SM/J m 101.0 15.0   4 7.49 0.148 81.2, 115.0 0.61
WSB/EiJ m 103.0 15.9   3 9.21 0.155 87.8, 120.0 0.71


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 102.4725 12.144 126.5689 78.3761
129X1/SvJ m 93.6 12.144 117.6964 69.5036
A/J m 91.085 12.144 115.1814 66.9886
AKR/J m 104.1275 12.144 128.2239 80.0311
BALB/cByJ m 100.815 12.144 124.9114 76.7186
BTBR T+ Itpr3tf/J m 48.5025 12.144 72.5989 24.4061
BUB/BnJ m 108.9275 12.144 133.0239 84.8311
C3H/HeJ m 88.065 12.144 112.1614 63.9686
C57BL/6J m 95.9625 12.144 120.0589 71.8661
C57BLKS/J m 69.3425 12.144 93.4389 45.2461
C58/J m 79.685 17.1743 113.7625 45.6075
CBA/J m 67.4975 12.144 91.5939 43.4011
CZECHII/EiJ m 113.575 12.144 137.6714 89.4786
DBA/2J m 63.61 12.144 87.7064 39.5136
FVB/NJ m 112.035 12.144 136.1314 87.9386
I/LnJ m 100.0325 12.144 124.1289 75.9361
KK/HlJ m 89.925 12.144 114.0214 65.8286
LG/J m 109.5325 12.144 133.6289 85.4361
LP/J m 102.035 12.144 126.1314 77.9386
MA/MyJ m 81.4725 12.144 105.5689 57.3761
NOD/ShiLtJ m 74.1575 12.144 98.2539 50.0611
NON/ShiLtJ m 79.56 12.144 103.6564 55.4636
NZB/BlNJ m 97.3525 12.144 121.4489 73.2561
NZO/HlLtJ m 28.75 12.144 52.8464 4.6536
NZW/LacJ m 68.18 12.144 92.2764 44.0836
PERA/EiJ m 87.6775 12.144 111.7739 63.5811
PL/J m 97.8375 12.144 121.9339 73.7411
PWD/PhJ m 115.9425 12.144 140.0389 91.8461
PWK/PhJ m 101.59 12.144 125.6864 77.4936
RIIIS/J m 99.625 12.144 123.7214 75.5286
SEA/GnJ m 87.21 12.144 111.3064 63.1136
SJL/J m 54.4575 12.144 78.5539 30.3611
SM/J m 101.2675 12.144 125.3639 77.1711
WSB/EiJ m 102.8 14.0227 130.6241 74.9759




  GWAS USING LINEAR MIXED MODELS