Project measure / variable:   Jentsch2   acquisition_FR1

ID, description, units MPD:49701   acquisition_FR1   number of sessions (days) required to reach criteria for self-administration (FR1 reinforcement schedule)   [d]  
cocaine study
Data set, strains Jentsch2   BXD   4 strains     sex: both     age: 8-17wks
Procedure operant conditioning chamber
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  STRAIN COMPARISON PLOT
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Jentsch2 - number of sessions (days) required to reach criteria for self-administration (FR1 reinforcement schedule)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested2 strains4 strains
Mean of the strain means9.40   d 8.48   d
Median of the strain means9.40   d 8.36   d
SD of the strain means± 4.10 ± 1.52
Coefficient of variation (CV)0.436 0.179
Min–max range of strain means6.50   –   12.3   d 7.00   –   10.2   d
Mean sample size per strain4.5   mice 10.5   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 29.6296 29.6296 6.6301 0.0169
strain 1 55.6217 55.6217 12.4463 0.0018
sex:strain 1 12.7037 12.7037 2.8427 0.1053
Residuals 23 102.7857 4.4689


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD31/TyJ m 10.2 0.422   10 0.133 0.0413 10.0, 11.0 1.13
BXD38/TyJ f 12.3 2.98   7 1.13 0.243 7.0, 16.0 0.71
BXD38/TyJ m 9.29 1.94   14 0.518 0.209 7.0, 13.0 0.53
BXD42/TyJ m 7.43 2.14   14 0.571 0.288 5.0, 10.0 -0.69
BXD68/RwwJ f 6.5 0.707   2   0.5 0.109 6.0, 7.0 -0.71
BXD68/RwwJ m 7.0 0.0   4 0.0 0.0 7.0, 7.0 -0.98


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD38/TyJ f 12.2857 0.799 13.9386 10.6328
BXD38/TyJ m 9.2857 0.565 10.4545 8.1169
BXD68/RwwJ f 6.5 1.4948 9.5923 3.4077
BXD68/RwwJ m 7.0 1.057 9.1866 4.8134


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
BXD38/TyJ both 10.7857 0.4893 11.7979 9.7735
BXD68/RwwJ both 6.75 0.9154 8.6436 4.8564




GWAS analysis not available: SNP data is not available for enough strains (at least 4)