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Project measure / variable:   Schauwecker1   ED100

ID, description, units MPD:47701   ED100   pilocarpine dose required to induce status epilepticus, mg/kg body weight   [mg/kg]  
pilocarpine study
Data set, strains Schauwecker1   inbred   8 strains     sex: m     age: 8-10wks
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  STRAIN COMPARISON PLOT
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Schauwecker1 - pilocarpine dose required to induce status epilepticus, mg/kg body weight



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested8 strains
Mean of the strain means306   mg/kg
Median of the strain means312   mg/kg
SD of the strain means± 79.5
Coefficient of variation (CV)0.260
Min–max range of strain means170   –   387   mg/kg
Mean sample size per strain4.2   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 7 204202.9657 29171.8522 6.741 0.0001
Residuals 26 112515.4167 4327.516


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129T2/SvEmsJ m 256.0 71.8   4 35.9 0.28 200.0, 350.0 -0.63
BALB/cByJ m 250.0 35.4   5 15.8 0.141 200.0, 300.0 -0.7
BALB/cJ m 387.0 43.0   5 19.2 0.111 350.0, 450.0 1.02
C3H/HeJ m 275.0 106.0   2   75.0 0.386 200.0, 350.0 -0.39
C57BL/6J m 375.0 75.0   5 33.5 0.2 250.0, 450.0 0.87
CBA/J m 170.0 110.0   5 49.0 0.644 100.0, 350.0 -1.71
DBA/2J m 383.0 38.2   3 22.0 0.0996 350.0, 425.0 0.97
FVB/NJ m 350.0 0.0   5 0.0 0.0 350.0, 350.0 0.56


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129T2/SvEmsJ m 256.25 32.8919 323.8603 188.6397
BALB/cByJ m 250.0 29.4194 310.4725 189.5275
BALB/cJ m 387.0 29.4194 447.4725 326.5275
C3H/HeJ m 275.0 46.5162 370.6154 179.3846
C57BL/6J m 375.0 29.4194 435.4725 314.5275
CBA/J m 170.0 29.4194 230.4725 109.5275
DBA/2J m 383.3333 37.9803 461.403 305.2637
FVB/NJ m 350.0 29.4194 410.4725 289.5275




  GWAS USING LINEAR MIXED MODELS