Project measure / variable:   Gould2   nicotine_acu

ID, description, units MPD:47101   nicotine_acu   plasma nicotine   [ng/mL]  acute 0.09mg dose  
nicotine study
Data set, strains Gould2   inbred   8 strains     sex: m     age:
Procedure drug and metabolite quantification
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  STRAIN COMPARISON PLOT
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Gould2 - plasma nicotine acute 0.09mg dose



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested8 strains
Mean of the strain means15.3   ng/mL
Median of the strain means15.2   ng/mL
SD of the strain means± 2.17
Coefficient of variation (CV)0.142
Min–max range of strain means11.8   –   19.2   ng/mL
Mean sample size per strain9.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 7 314.7141 44.9592 1.2123 0.3077
Residuals 70 2596.0856 37.0869


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S6/SvEvTac m 16.3 4.1   10 1.3 0.251 12.0, 25.4 0.47
A/J m 14.1 5.19   10 1.64 0.368 4.4, 21.7 -0.54
BALB/cByJ m 15.9 9.58   10 3.03 0.603 2.8, 38.0 0.29
C3H/HeJ m 14.3 3.12   10 0.986 0.218 10.7, 20.0 -0.45
C57BL/6J m 11.8 4.43   10 1.4 0.377 7.8, 20.2 -1.6
CBA/J m 19.2 8.58   9 2.86 0.448 10.0, 30.9 1.81
DBA/1J m 16.2 5.34   9 1.78 0.329 11.5, 28.4 0.43
DBA/2J m 14.4 5.72   10 1.81 0.397 8.1, 27.7 -0.4


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S6/SvEvTac m 16.33 1.9258 20.1709 12.4891
A/J m 14.11 1.9258 17.9509 10.2691
BALB/cByJ m 15.9 1.9258 19.7409 12.0591
C3H/HeJ m 14.3 1.9258 18.1409 10.4591
C57BL/6J m 11.76 1.9258 15.6009 7.9191
CBA/J m 19.1778 2.03 23.2264 15.1291
DBA/1J m 16.2333 2.03 20.282 12.1847
DBA/2J m 14.38 1.9258 18.2209 10.5391




  GWAS USING LINEAR MIXED MODELS