Project measure / variable:   Marchuk1   infarct_vol

ID, description, units MPD:45001   infarct_vol   infarct volume following surgically-induced focal cerebral ischemia   [mm3]  
Data set, strains Marchuk1   inbred   16 strains     sex: both     age: 11-13wks
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  STRAIN COMPARISON PLOT
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Marchuk1 - infarct volume following surgically-induced focal cerebral ischemia



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested15 strains16 strains
Mean of the strain means11.1   mm3 11.2   mm3
Median of the strain means4.19   mm3 6.25   mm3
SD of the strain means± 10.8 ± 10.4
Coefficient of variation (CV)0.980 0.924
Min–max range of strain means0.733   –   29.4   mm3 0.967   –   30.6   mm3
Mean sample size per strain3.7   mice 4.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 20.9243 20.9243 1.2692 0.2629
strain 14 11907.4861 850.5347 51.5909 < 0.0001
sex:strain 14 250.8878 17.9206 1.087 0.3799
Residuals 91 1500.2377 16.4861


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 3.13 1.95   3 1.13 0.624 0.88, 4.37 -0.73
129S1/SvImJ m 5.24 2.91   4 1.46 0.556 2.19, 8.96 -0.58
A/J f 29.4 7.0   3 4.04 0.238 22.9, 36.8 1.69
A/J m 22.7 1.97   4 0.984 0.0866 19.9, 24.1 1.11
AKR/J f 23.4 1.78   2   1.26 0.0762 22.1, 24.6 1.14
AKR/J m 25.8 7.32   3 4.23 0.284 17.4, 30.9 1.41
BALB/cByJ f 25.6 10.4   4 5.21 0.407 17.6, 39.7 1.34
BALB/cByJ m 27.5 8.06   4 4.03 0.293 20.0, 38.9 1.57
BTBR T+ Itpr3tf/J f 14.3 3.15   2   2.22 0.22 12.1, 16.5 0.3
BTBR T+ Itpr3tf/J m 7.26 3.67   4 1.84 0.506 3.41, 12.2 -0.38
C3H/HeJ f 17.0 2.18   5 0.976 0.128 14.3, 20.0 0.55
C3H/HeJ m 20.7 6.51   6 2.66 0.314 11.2, 28.9 0.92
C57BL/6J f 3.44 3.47   5 1.55 1.01 0.6, 7.97 -0.7
C57BL/6J m 4.54 3.17   7 1.2 0.698 1.78, 11.1 -0.64
C57BLKS/J f 0.935 0.746   4 0.373 0.798 0.39, 2.02 -0.93
C57BLKS/J m 0.967 0.274   3 0.158 0.283 0.67, 1.21 -0.99
CBA/J f 0.885 0.271   4 0.135 0.306 0.65, 1.24 -0.94
CBA/J m 2.85 1.8   5 0.805 0.632 0.56, 4.6 -0.81
DBA/2J f 2.12 3.39   4 1.7 1.6 0.22, 7.19 -0.82
DBA/2J m 2.54 1.18   4 0.591 0.464 0.95, 3.55 -0.84
FVB/NJ f 0.733 0.403   3 0.232 0.549 0.43, 1.19 -0.95
FVB/NJ m 3.95 5.05   4 2.52 1.28 0.25, 11.4 -0.7
KK/HlJ m 10.0 2.71   4 1.36 0.271 6.99, 12.7 -0.12
NOD/ShiLtJ f 4.19 2.95   4 1.47 0.703 1.61, 7.6 -0.63
NOD/ShiLtJ m 2.82 1.27   5 0.568 0.45 0.95, 4.19 -0.81
NZW/LacJ f 9.42 3.68   4 1.84 0.39 7.44, 14.9 -0.15
NZW/LacJ m 7.56 4.02   4 2.01 0.532 3.59, 12.4 -0.35
SJL/J f 3.51 2.36   5 1.06 0.673 0.97, 7.28 -0.7
SJL/J m 4.3 3.5   5 1.56 0.813 1.46, 10.2 -0.67
SWR/J f 27.7 0.3   3 0.173 0.0108 27.4, 28.0 1.54
SWR/J m 30.6 2.11   4 1.05 0.0688 29.2, 33.7 1.87


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 3.1333 2.3442 7.7898 0.0
129S1/SvImJ m 5.235 2.0302 9.2677 1.2023
A/J f 29.3633 2.3442 34.0198 24.7068
A/J m 22.74 2.0302 26.7727 18.7073
AKR/J f 23.39 2.8711 29.093 17.687
AKR/J m 25.7667 2.3442 30.4232 21.1102
BALB/cByJ f 25.585 2.0302 29.6177 21.5523
BALB/cByJ m 27.5425 2.0302 31.5752 23.5098
BTBR T+ Itpr3tf/J f 14.295 2.8711 19.998 8.592
BTBR T+ Itpr3tf/J m 7.265 2.0302 11.2977 3.2323
C3H/HeJ f 17.01 1.8158 20.6169 13.4031
C3H/HeJ m 20.7083 1.6576 24.001 17.4157
C57BL/6J f 3.438 1.8158 7.0449 0.0
C57BL/6J m 4.54 1.5347 7.5884 1.4916
C57BLKS/J f 0.935 2.0302 4.9677 0.0
C57BLKS/J m 0.9667 2.3442 5.6232 0.0
CBA/J f 0.885 2.0302 4.9177 0.0
CBA/J m 2.85 1.8158 6.4569 0.0
DBA/2J f 2.1175 2.0302 6.1502 0.0
DBA/2J m 2.545 2.0302 6.5777 0.0
FVB/NJ f 0.7333 2.3442 5.3898 0.0
FVB/NJ m 3.9525 2.0302 7.9852 0.0
NOD/ShiLtJ f 4.19 2.0302 8.2227 0.1573
NOD/ShiLtJ m 2.82 1.8158 6.4269 0.0
NZW/LacJ f 9.4225 2.0302 13.4552 5.3898
NZW/LacJ m 7.5625 2.0302 11.5952 3.5298
SJL/J f 3.51 1.8158 7.1169 0.0
SJL/J m 4.3 1.8158 7.9069 0.6931
SWR/J f 27.7367 2.3442 32.3932 23.0802
SWR/J m 30.5975 2.0302 34.6302 26.5648


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 4.1842 1.5506 7.2642 1.1042
A/J both 26.0517 1.5506 29.1317 22.9717
AKR/J both 24.5783 1.8533 28.2596 20.897
BALB/cByJ both 26.5637 1.4355 29.4153 23.7122
BTBR T+ Itpr3tf/J both 10.78 1.7582 14.2724 7.2876
C3H/HeJ both 18.8592 1.2293 21.3011 16.4173
C57BL/6J both 3.989 1.1887 6.3503 1.6277
C57BLKS/J both 0.9508 1.5506 4.0308 0.0
CBA/J both 1.8675 1.3619 4.5727 0.0
DBA/2J both 2.3313 1.4355 5.1828 0.0
FVB/NJ both 2.3429 1.5506 5.4229 0.0
NOD/ShiLtJ both 3.505 1.3619 6.2102 0.7998
NZW/LacJ both 8.4925 1.4355 11.344 5.641
SJL/J both 3.905 1.284 6.4555 1.3545
SWR/J both 29.1671 1.5506 32.2471 26.0871




  GWAS USING LINEAR MIXED MODELS