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Project measure / variable:   Chesler2   anion_gap

ID, description, units MPD:43405   anion_gap   anion gap concentration (mEq/L)   [mmol/L]  
Data set, strains Chesler2   CC diallel w/par   48 strains     sex: both     age: 7-15wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Chesler2 - anion gap concentration (mEq/L)



  8-WAY DIALLEL CROSS VIEW
Female animals
129S ♂ A ♂ B6 ♂ CAST ♂ NOD ♂ NZO ♂ PWK ♂ WSB ♂
129S ♀ — 17.0 15.0 15.0 — — 13.0 —
A ♀ — — 15.0 — — 13.0 — —
B6 ♀ 13.5 16.0 16.9 — 15.0 12.0 14.0 —
CAST ♀ — 20.0 11.0 18.4 — 15.0 14.4 16.5
NOD ♀ — 15.0 13.3 — 14.0 11.5 — —
NZO ♀ 13.0 15.0 — — — — — 12.0
PWK ♀ 13.0 15.0 — — 17.0 — — —
WSB ♀ 14.0 17.0 19.0 — 15.0 12.7 17.0 20.0

Male animals
129S ♂ A ♂ B6 ♂ CAST ♂ NOD ♂ NZO ♂ PWK ♂ WSB ♂
129S ♀ — 12.0 13.0 — 14.5 11.0 — —
A ♀ — 15.2 16.5 — 12.6 — 16.0 16.0
B6 ♀ — 16.0 12.5 — 14.0 9.00 — —
CAST ♀ 15.0 15.0 17.3 15.5 15.0 15.0 14.5 —
NOD ♀ — — — — 12.0 10.0 — —
NZO ♀ — — 9.00 — 16.0 6.00 — —
PWK ♀ — 14.0 — — — — 9.50 —
WSB ♀ — 20.0 15.3 18.7 12.5 12.5 — 21.5

Cell coloring is based on strain mean Z-scores.     High-end         Mid         Low-end           Mouse over the cells to see additional info.


  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested35 strains33 strains
Mean of the strain means15.0   mmol/L 14.0   mmol/L
Median of the strain means15.0   mmol/L 14.5   mmol/L
SD of the strain means± 2.28 ± 3.23
Coefficient of variation (CV)0.152 0.231
Min–max range of strain means11.0   –   20.0   mmol/L 6.00   –   21.5   mmol/L
Mean sample size per strain1.8   mice 2.2   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 158.6675 158.6675 48.5766 < 0.0001
strain 6 305.2721 50.8787 15.5767 < 0.0001
sex:strain 6 85.34 14.2233 4.3545 0.0008
Residuals 74 241.7091 3.2663


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129SAF1 f 17.0 0.0   1   0.0 0.0 17.0, 17.0 0.89
129SAF1 m 12.0 2.83   2   2.0 0.236 10.0, 14.0 -0.62
129SB6F1 f 15.0 1.41   2   1.0 0.0943 14.0, 16.0 0.01
129SB6F1 m 13.0 0.0   2   0.0 0.0 13.0, 13.0 -0.32
129SCASTF1 f 15.0 0.0   2   0.0 0.0 15.0, 15.0 0.01
129SNODF1 m 14.5 0.707   2   0.5 0.0488 14.0, 15.0 0.15
129SNZOF1 m 11.0 1.41   2   1.0 0.129 10.0, 12.0 -0.93
129SPWKF1 f 13.0 0.0   1   0.0 0.0 13.0, 13.0 -0.87
AB6F1 f 15.0 0.0   1   0.0 0.0 15.0, 15.0 0.01
AB6F1 m 16.5 3.87   4 1.94 0.235 13.0, 22.0 0.77
A/J m 15.2 1.5   4 0.75 0.0984 14.0, 17.0 0.37
ANODF1 m 12.6 1.13   7 0.429 0.0902 11.0, 14.0 -0.44
ANZOF1 f 13.0 0.0   1   0.0 0.0 13.0, 13.0 -0.87
APWKF1 m 16.0 0.0   1   0.0 0.0 16.0, 16.0 0.61
AWSBF1 m 16.0 0.0   1   0.0 0.0 16.0, 16.0 0.61
B6129SF1/J f 13.5 0.707   2   0.5 0.0524 13.0, 14.0 -0.65
B6AF1/J f 16.0 0.0   1   0.0 0.0 16.0, 16.0 0.45
B6AF1/J m 16.0 0.0   1   0.0 0.0 16.0, 16.0 0.61
B6NODF1 f 15.0 0.0   1   0.0 0.0 15.0, 15.0 0.01
B6NODF1 m 14.0 0.0   2   0.0 0.0 14.0, 14.0 -0.01
B6NZOF1 f 12.0 0.0   1   0.0 0.0 12.0, 12.0 -1.31
B6NZOF1 m 9.0 0.0   1   0.0 0.0 9.0, 9.0 -1.55
B6PWKF1 f 14.0 0.0   1   0.0 0.0 14.0, 14.0 -0.43
C57BL/6J f 16.9 1.36   15 0.35 0.0804 15.0, 19.0 0.84
C57BL/6J m 12.5 1.87   33 0.326 0.15 9.0, 17.0 -0.47
CAST129SF1 m 15.0 0.0   2   0.0 0.0 15.0, 15.0 0.3
CASTAF1 f 20.0 0.0   1   0.0 0.0 20.0, 20.0 2.2
CASTAF1 m 15.0 0.0   2   0.0 0.0 15.0, 15.0 0.3
CASTB6F1 f 11.0 0.0   1   0.0 0.0 11.0, 11.0 -1.75
CASTB6F1 m 17.3 0.577   3 0.333 0.0333 17.0, 18.0 1.02
CAST/EiJ f 18.4 2.79   5 1.25 0.152 16.0, 23.0 1.5
CAST/EiJ m 15.5 0.707   2   0.5 0.0456 15.0, 16.0 0.46
CASTNODF1 m 15.0 0.0   1   0.0 0.0 15.0, 15.0 0.3
CASTNZOF1 f 15.0 1.41   4 0.707 0.0943 14.0, 17.0 0.01
CASTNZOF1 m 15.0 0.0   1   0.0 0.0 15.0, 15.0 0.3
CASTPWKF1 f 14.4 1.14   5 0.51 0.0792 13.0, 16.0 -0.25
CASTPWKF1 m 14.5 1.38   6 0.563 0.0951 13.0, 16.0 0.15
CASTWSBF1 f 16.5 2.12   2   1.5 0.129 15.0, 18.0 0.67
NODAF1 f 15.0 0.0   1   0.0 0.0 15.0, 15.0 0.01
NODB6F1 f 13.3 1.15   3 0.667 0.0866 12.0, 14.0 -0.74
NODNZOF1 f 11.5 0.707   2   0.5 0.0615 11.0, 12.0 -1.53
NODNZOF1 m 10.0 0.0   2   0.0 0.0 10.0, 10.0 -1.24
NOD/ShiLtJ f 14.0 0.0   1   0.0 0.0 14.0, 14.0 -0.43
NOD/ShiLtJ m 12.0 0.0   1   0.0 0.0 12.0, 12.0 -0.62
NZO129SF1 f 13.0 0.0   1   0.0 0.0 13.0, 13.0 -0.87
NZOAF1 f 15.0 0.0   1   0.0 0.0 15.0, 15.0 0.01
NZOB6F1 m 9.0 0.0   1   0.0 0.0 9.0, 9.0 -1.55
NZO/HlLtJ m 6.0 0.0   1   0.0 0.0 6.0, 6.0 -2.48
NZONODF1 m 16.0 0.0   1   0.0 0.0 16.0, 16.0 0.61
NZOWSBF1 f 12.0 0.0   3 0.0 0.0 12.0, 12.0 -1.31
PWK129SF1 f 13.0 0.0   1   0.0 0.0 13.0, 13.0 -0.87
PWKAF1 f 15.0 0.0   1   0.0 0.0 15.0, 15.0 0.01
PWKAF1 m 14.0 0.0   1   0.0 0.0 14.0, 14.0 -0.01
PWKNODF1 f 17.0 0.0   1   0.0 0.0 17.0, 17.0 0.89
PWK/PhJ m 9.5 7.78   2   5.5 0.819 4.0, 15.0 -1.4
WSB129SF1 f 14.0 0.0   1   0.0 0.0 14.0, 14.0 -0.43
WSBAF1 f 17.0 0.0   1   0.0 0.0 17.0, 17.0 0.89
WSBAF1 m 20.0 0.0   1   0.0 0.0 20.0, 20.0 1.85
WSBB6F1 f 19.0 0.0   1   0.0 0.0 19.0, 19.0 1.77
WSBB6F1 m 15.3 3.21   3 1.86 0.21 13.0, 19.0 0.4
WSBCASTF1 m 18.7 2.08   3 1.2 0.112 17.0, 21.0 1.45
WSB/EiJ f 20.0 4.24   2   3.0 0.212 17.0, 23.0 2.2
WSB/EiJ m 21.5 2.12   2   1.5 0.0987 20.0, 23.0 2.31
WSBNODF1 f 15.0 0.0   1   0.0 0.0 15.0, 15.0 0.01
WSBNODF1 m 12.5 2.12   2   1.5 0.17 11.0, 14.0 -0.47
WSBNZOF1 f 12.7 1.75   6 0.715 0.138 10.0, 15.0 -1.0
WSBNZOF1 m 12.5 2.38   4 1.19 0.19 10.0, 15.0 -0.47
WSBPWKF1 f 17.0 2.83   2   2.0 0.166 15.0, 19.0 0.89


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129SB6F1 f 15.0 1.278 17.5464 12.4536
129SB6F1 m 13.0 1.278 15.5464 10.4536
C57BL/6J f 16.8667 0.4666 17.7965 15.9369
C57BL/6J m 12.4848 0.3146 13.1117 11.858
CAST/EiJ f 18.4 0.8082 20.0105 16.7895
CAST/EiJ m 15.5 1.278 18.0464 12.9536
CASTPWKF1 f 14.4 0.8082 16.0105 12.7895
CASTPWKF1 m 14.5 0.7378 15.9702 13.0298
NODNZOF1 f 11.5 1.278 14.0464 8.9536
NODNZOF1 m 10.0 1.278 12.5464 7.4536
WSB/EiJ f 20.0 1.278 22.5464 17.4536
WSB/EiJ m 21.5 1.278 24.0464 18.9536
WSBNZOF1 f 12.6667 0.7378 14.1368 11.1965
WSBNZOF1 m 12.5 0.9037 14.3006 10.6994


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129SB6F1 both 14.0 0.9037 15.8006 12.1994
C57BL/6J both 14.6758 0.2814 15.2365 14.1151
CAST/EiJ both 16.95 0.756 18.4565 15.4435
CASTPWKF1 both 14.45 0.5472 15.5403 13.3597
NODNZOF1 both 10.75 0.9037 12.5506 8.9494
WSB/EiJ both 20.75 0.9037 22.5506 18.9494
WSBNZOF1 both 12.5833 0.5833 13.7456 11.4211




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA