Project measure / variable:   Thomsen2   activ_D2_doseC

ID, description, units MPD:40809   activ_D2_doseC   total activity, dose response to D2 agonist, 3h test   [n]  dose 3.2 mg/kg i.p.  
quinelorane study
Data set, strains Thomsen2   inbred   15 strains     sex: both     age: 8-10wks
Procedure open field test
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  STRAIN COMPARISON PLOT
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Thomsen2 - total activity, dose response to D2 agonist, 3h test dose 3.2 mg/kg i.p.



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested15 strains15 strains
Mean of the strain means2421   n 2892   n
Median of the strain means1149   n 671   n
SD of the strain means± 4496 ± 6013
Coefficient of variation (CV)1.86 2.08
Min–max range of strain means185   –   18035   n 138   –   23940   n
Mean sample size per strain7.6   mice 7.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 2245117.2705 2245117.2705 0.7611 0.384
strain 14 3610034997.9686 257859642.712 87.4183 < 0.0001
sex:strain 14 92329078.4874 6594934.1777 2.2358 0.0079
Residuals 195 575195429.5357 2949720.1515


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 189.0 76.2   8 26.9 0.403 102.0, 305.0 -0.5
129S1/SvImJ m 293.0 91.4   8 32.3 0.312 120.0, 386.0 -0.43
129S6/SvEvTac f 474.0 306.0   8 108.0 0.645 15.0, 857.0 -0.43
129S6/SvEvTac m 239.0 61.2   8 21.6 0.256 149.0, 315.0 -0.44
129X1/SvJ f 185.0 95.1   8 33.6 0.513 92.0, 361.0 -0.5
129X1/SvJ m 138.0 89.0   8 31.5 0.646 68.0, 310.0 -0.46
A/J f 310.0 201.0   8 71.2 0.649 93.0, 675.0 -0.47
A/J m 361.0 288.0   7 109.0 0.798 77.0, 914.0 -0.42
BALB/cByJ f 1796.0 1997.0   7 755.0 1.11 419.0, 5259.0 -0.14
BALB/cByJ m 913.0 1374.0   8 486.0 1.5 93.0, 3611.0 -0.33
BALB/cJ f 2265.0 1921.0   8 679.0 0.848 567.0, 5596.0 -0.03
BALB/cJ m 3590.0 1499.0   8 530.0 0.418 1306.0, 5696.0 0.12
C3H/HeJ f 3758.0 2387.0   8 844.0 0.635 1033.0, 8214.0 0.3
C3H/HeJ m 4359.0 2991.0   8 1057.0 0.686 1161.0, 10171.0 0.24
C57BL/6J f 248.0 87.3   8 30.9 0.353 134.0, 406.0 -0.48
C57BL/6J m 378.0 114.0   7 42.9 0.301 185.0, 552.0 -0.42
CAST/EiJ f 18035.0 7264.0   5 3249.0 0.403 10635.0, 25831.0 3.47
CAST/EiJ m 23940.0 2828.0   4 1414.0 0.118 20763.0, 27474.0 3.5
Crl:CD-1(ICR) f 540.0 539.0   8 191.0 0.999 244.0, 1854.0 -0.42
Crl:CD-1(ICR) m 1305.0 1434.0   8 507.0 1.1 113.0, 3584.0 -0.26
DBA/2J f 498.0 391.0   7 148.0 0.785 150.0, 1103.0 -0.43
DBA/2J m 336.0 464.0   8 164.0 1.38 21.0, 1447.0 -0.43
FVB/NJ f 1271.0 821.0   8 290.0 0.646 577.0, 2909.0 -0.26
FVB/NJ m 2007.0 1316.0   8 465.0 0.655 495.0, 4127.0 -0.15
SJL/J f 1149.0 514.0   8 182.0 0.448 645.0, 2094.0 -0.28
SJL/J m 526.0 248.0   8 87.6 0.472 222.0, 921.0 -0.39
SPRET/EiJ f 4134.0 2228.0   5 997.0 0.539 1363.0, 6916.0 0.38
SPRET/EiJ m 4327.0 3691.0   7 1395.0 0.853 1388.0, 11723.0 0.24
Tac:SW f 1459.0 1308.0   8 463.0 0.897 227.0, 3908.0 -0.21
Tac:SW m 671.0 889.0   8 314.0 1.33 150.0, 2731.0 -0.37


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 189.125 607.2191 1386.6849 0.0
129S1/SvImJ m 293.25 607.2191 1490.8099 0.0
129S6/SvEvTac f 474.0 607.2191 1671.5599 0.0
129S6/SvEvTac m 238.875 607.2191 1436.4349 0.0
129X1/SvJ f 185.375 607.2191 1382.9349 0.0
129X1/SvJ m 137.875 607.2191 1335.4349 0.0
A/J f 310.375 607.2191 1507.9349 0.0
A/J m 361.1429 649.1445 1641.3883 0.0
BALB/cByJ f 1796.1429 649.1445 3076.3883 515.8974
BALB/cByJ m 913.125 607.2191 2110.6849 0.0
BALB/cJ f 2264.875 607.2191 3462.4349 1067.3151
BALB/cJ m 3589.875 607.2191 4787.4349 2392.3151
C3H/HeJ f 3758.125 607.2191 4955.6849 2560.5651
C3H/HeJ m 4359.25 607.2191 5556.8099 3161.6901
C57BL/6J f 247.5 607.2191 1445.0599 0.0
C57BL/6J m 377.7143 649.1445 1657.9597 0.0
CAST/EiJ f 18034.8 768.0781 19549.6068 16519.9932
CAST/EiJ m 23940.5 858.7375 25634.1055 22246.8945
Crl:CD-1(ICR) f 539.875 607.2191 1737.4349 0.0
Crl:CD-1(ICR) m 1305.375 607.2191 2502.9349 107.8151
DBA/2J f 497.5714 649.1445 1777.8169 0.0
DBA/2J m 335.75 607.2191 1533.3099 0.0
FVB/NJ f 1271.0 607.2191 2468.5599 73.4401
FVB/NJ m 2007.375 607.2191 3204.9349 809.8151
SJL/J f 1149.125 607.2191 2346.6849 0.0
SJL/J m 525.5 607.2191 1723.0599 0.0
SPRET/EiJ f 4133.6 768.0781 5648.4068 2618.7932
SPRET/EiJ m 4326.7143 649.1445 5606.9597 3046.4689
Tac:SW f 1458.75 607.2191 2656.3099 261.1901
Tac:SW m 670.875 607.2191 1868.4349 0.0


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 241.1875 429.3687 1087.9903 0.0
129S6/SvEvTac both 356.4375 429.3687 1203.2403 0.0
129X1/SvJ both 161.625 429.3687 1008.4278 0.0
A/J both 335.7589 444.4389 1212.2831 0.0
BALB/cByJ both 1354.6339 444.4389 2231.1581 478.1098
BALB/cJ both 2927.375 429.3687 3774.1778 2080.5722
C3H/HeJ both 4058.6875 429.3687 4905.4903 3211.8847
C57BL/6J both 312.6071 444.4389 1189.1313 0.0
CAST/EiJ both 20987.65 576.0586 22123.7551 19851.5449
Crl:CD-1(ICR) both 922.625 429.3687 1769.4278 75.8222
DBA/2J both 416.6607 444.4389 1293.1848 0.0
FVB/NJ both 1639.1875 429.3687 2485.9903 792.3847
SJL/J both 837.3125 429.3687 1684.1153 0.0
SPRET/EiJ both 4230.1571 502.8252 5221.831 3238.4833
Tac:SW both 1064.8125 429.3687 1911.6153 218.0097




  GWAS USING LINEAR MIXED MODELS