Project measure / variable:   Thomsen2   activ_D2_doseB

ID, description, units MPD:40808   activ_D2_doseB   total activity, dose response to D2 agonist, 3h test   [n]  dose 0.32 mg/kg i.p.  
quinelorane study
Data set, strains Thomsen2   inbred   15 strains     sex: both     age: 8-10wks
Procedure open field test
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  STRAIN COMPARISON PLOT
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Thomsen2 - total activity, dose response to D2 agonist, 3h test dose 0.32 mg/kg i.p.



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested15 strains15 strains
Mean of the strain means1609   n 1858   n
Median of the strain means783   n 523   n
SD of the strain means± 2383 ± 3916
Coefficient of variation (CV)1.48 2.11
Min–max range of strain means143   –   9225   n 114   –   15675   n
Mean sample size per strain7.6   mice 7.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 99411.2892 99411.2892 0.0514 0.821
strain 14 1241739378.2055 88695669.8718 45.8189 < 0.0001
sex:strain 14 110411739.4868 7886552.8205 4.0741 < 0.0001
Residuals 195 377478660.3786 1935788.0019


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 221.0 116.0   8 40.9 0.523 84.0, 379.0 -0.58
129S1/SvImJ m 245.0 96.6   8 34.2 0.395 128.0, 443.0 -0.41
129S6/SvEvTac f 269.0 167.0   8 59.0 0.62 1.0, 444.0 -0.56
129S6/SvEvTac m 124.0 39.6   8 14.0 0.318 65.0, 178.0 -0.44
129X1/SvJ f 143.0 64.2   8 22.7 0.449 68.0, 265.0 -0.61
129X1/SvJ m 148.0 70.3   8 24.8 0.475 59.0, 274.0 -0.44
A/J f 377.0 141.0   8 49.7 0.373 182.0, 590.0 -0.52
A/J m 365.0 185.0   7 70.0 0.507 118.0, 628.0 -0.38
BALB/cByJ f 1623.0 1978.0   7 748.0 1.22 225.0, 5678.0 0.01
BALB/cByJ m 1066.0 1719.0   8 608.0 1.61 66.0, 4574.0 -0.2
BALB/cJ f 1324.0 775.0   8 274.0 0.585 468.0, 2915.0 -0.12
BALB/cJ m 1394.0 735.0   8 260.0 0.528 649.0, 2799.0 -0.12
C3H/HeJ f 1588.0 1097.0   8 388.0 0.69 452.0, 3622.0 -0.01
C3H/HeJ m 2426.0 1036.0   8 366.0 0.427 919.0, 3738.0 0.15
C57BL/6J f 468.0 198.0   8 70.1 0.424 279.0, 789.0 -0.48
C57BL/6J m 450.0 160.0   7 60.6 0.356 279.0, 637.0 -0.36
CAST/EiJ f 9225.0 5411.0   5 2420.0 0.587 1837.0, 14467.0 3.2
CAST/EiJ m 15675.0 5592.0   4 2796.0 0.357 8611.0, 21651.0 3.53
Crl:CD-1(ICR) f 328.0 134.0   8 47.5 0.409 168.0, 630.0 -0.54
Crl:CD-1(ICR) m 956.0 968.0   8 342.0 1.01 186.0, 2852.0 -0.23
DBA/2J f 162.0 110.0   7 41.4 0.676 77.0, 320.0 -0.61
DBA/2J m 114.0 55.1   8 19.5 0.485 20.0, 161.0 -0.45
FVB/NJ f 2101.0 1686.0   8 596.0 0.802 736.0, 5927.0 0.21
FVB/NJ m 1151.0 770.0   8 272.0 0.669 454.0, 2942.0 -0.18
SJL/J f 783.0 216.0   8 76.2 0.275 481.0, 1125.0 -0.35
SJL/J m 523.0 202.0   8 71.6 0.387 263.0, 829.0 -0.34
SPRET/EiJ f 4409.0 2597.0   5 1162.0 0.589 2657.0, 8843.0 1.17
SPRET/EiJ m 2969.0 2195.0   7 830.0 0.739 1268.0, 7035.0 0.28
Tac:SW f 1109.0 1181.0   8 418.0 1.07 239.0, 3570.0 -0.21
Tac:SW m 262.0 133.0   8 47.0 0.507 102.0, 499.0 -0.41


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 221.125 491.908 1191.268 0.0
129S1/SvImJ m 244.625 491.908 1214.768 0.0
129S6/SvEvTac f 269.0 491.908 1239.143 0.0
129S6/SvEvTac m 124.5 491.908 1094.643 0.0
129X1/SvJ f 143.125 491.908 1113.268 0.0
129X1/SvJ m 148.0 491.908 1118.143 0.0
A/J f 377.25 491.908 1347.393 0.0
A/J m 365.4286 525.8718 1402.5551 0.0
BALB/cByJ f 1622.5714 525.8718 2659.6979 585.4449
BALB/cByJ m 1065.75 491.908 2035.893 95.607
BALB/cJ f 1323.875 491.908 2294.018 353.732
BALB/cJ m 1393.625 491.908 2363.768 423.482
C3H/HeJ f 1588.375 491.908 2558.518 618.232
C3H/HeJ m 2426.375 491.908 3396.518 1456.232
C57BL/6J f 467.5 491.908 1437.643 0.0
C57BL/6J m 450.0 525.8718 1487.1265 0.0
CAST/EiJ f 9225.4 622.2199 10452.5446 7998.2554
CAST/EiJ m 15675.0 695.663 17046.9894 14303.0106
Crl:CD-1(ICR) f 328.375 491.908 1298.518 0.0
Crl:CD-1(ICR) m 955.5 491.908 1925.643 0.0
DBA/2J f 162.0 525.8718 1199.1265 0.0
DBA/2J m 113.625 491.908 1083.768 0.0
FVB/NJ f 2101.375 491.908 3071.518 1131.232
FVB/NJ m 1150.75 491.908 2120.893 180.607
SJL/J f 782.875 491.908 1753.018 0.0
SJL/J m 522.625 491.908 1492.768 0.0
SPRET/EiJ f 4409.0 622.2199 5636.1446 3181.8554
SPRET/EiJ m 2969.0 525.8718 4006.1265 1931.8735
Tac:SW f 1109.125 491.908 2079.268 138.982
Tac:SW m 262.375 491.908 1232.518 0.0


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 232.875 347.8315 918.8697 0.0
129S6/SvEvTac both 196.75 347.8315 882.7447 0.0
129X1/SvJ both 145.5625 347.8315 831.5572 0.0
A/J both 371.3393 360.0398 1081.4112 0.0
BALB/cByJ both 1344.1607 360.0398 2054.2327 634.0888
BALB/cJ both 1358.75 347.8315 2044.7447 672.7553
C3H/HeJ both 2007.375 347.8315 2693.3697 1321.3803
C57BL/6J both 458.75 360.0398 1168.822 0.0
CAST/EiJ both 12450.2 466.6649 13370.5585 11529.8415
Crl:CD-1(ICR) both 641.9375 347.8315 1327.9322 0.0
DBA/2J both 137.8125 360.0398 847.8845 0.0
FVB/NJ both 1626.0625 347.8315 2312.0572 940.0678
SJL/J both 652.75 347.8315 1338.7447 0.0
SPRET/EiJ both 3689.0 407.3385 4492.3547 2885.6453
Tac:SW both 685.75 347.8315 1371.7447 0.0




  GWAS USING LINEAR MIXED MODELS