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Project measure / variable:   Thomsen1   activ_cocaine2_10

ID, description, units MPD:40709   activ_cocaine2_10   total activity, test 2, 3h test   [n]  dose 10 mg/kg  
cocaine study
Data set, strains Thomsen1   inbred   15 strains     sex: both     age: 8-10wks
Procedure open field test
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  STRAIN COMPARISON PLOT
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Thomsen1 - total activity, test 2, 3h test dose 10 mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested15 strains15 strains
Mean of the strain means4000   n 3414   n
Median of the strain means4351   n 3272   n
SD of the strain means± 3158 ± 2938
Coefficient of variation (CV)0.790 0.861
Min–max range of strain means391   –   11358   n 388   –   9572   n
Mean sample size per strain7.8   mice 7.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 31520443.5178 31520443.5178 6.7479 0.0101
strain 14 1742413902.0832 124458135.8631 26.6439 < 0.0001
sex:strain 14 150842020.9413 10774430.0672 2.3066 0.0059
Residuals 201 938903833.4405 4671163.3505


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 836.0 319.0   8 113.0 0.382 405.0, 1314.0 -1.0
129S1/SvImJ m 843.0 322.0   8 114.0 0.382 413.0, 1290.0 -0.88
129S6/SvEvTac f 391.0 173.0   8 61.0 0.442 138.0, 622.0 -1.14
129S6/SvEvTac m 388.0 206.0   8 72.9 0.531 190.0, 724.0 -1.03
129X1/SvJ f 427.0 262.0   8 92.6 0.613 102.0, 852.0 -1.13
129X1/SvJ m 447.0 337.0   8 119.0 0.754 88.0, 930.0 -1.01
A/J f 2036.0 1167.0   8 412.0 0.573 496.0, 3540.0 -0.62
A/J m 1540.0 669.0   8 237.0 0.434 912.0, 2647.0 -0.64
BALB/cByJ f 5244.0 1590.0   8 562.0 0.303 2581.0, 7265.0 0.39
BALB/cByJ m 6651.0 876.0   8 310.0 0.132 5473.0, 8084.0 1.1
BALB/cJ f 5139.0 2461.0   7 930.0 0.479 1073.0, 8175.0 0.36
BALB/cJ m 3865.0 3188.0   8 1127.0 0.825 995.0, 9990.0 0.15
C3H/HeJ f 1374.0 573.0   8 203.0 0.417 837.0, 2377.0 -0.83
C3H/HeJ m 3470.0 1258.0   8 445.0 0.363 1303.0, 4990.0 0.02
C57BL/6J f 7686.0 5272.0   7 1993.0 0.686 3367.0, 19254.0 1.17
C57BL/6J m 4040.0 1685.0   8 596.0 0.417 1935.0, 7353.0 0.21
CAST/EiJ f 7069.0 2529.0   8 894.0 0.358 4079.0, 10525.0 0.97
CAST/EiJ m 9572.0 3149.0   4 1574.0 0.329 6855.0, 13993.0 2.1
Crl:CD-1(ICR) f 4581.0 5116.0   8 1809.0 1.12 542.0, 15664.0 0.18
Crl:CD-1(ICR) m 3349.0 2461.0   8 870.0 0.735 562.0, 6898.0 -0.02
DBA/2J f 5724.0 2891.0   8 1022.0 0.505 2062.0, 10928.0 0.55
DBA/2J m 2766.0 1530.0   8 541.0 0.553 845.0, 4594.0 -0.22
FVB/NJ f 11358.0 2041.0   8 722.0 0.18 8604.0, 13838.0 2.33
FVB/NJ m 9028.0 2548.0   8 901.0 0.282 5943.0, 13898.0 1.91
SJL/J f 2514.0 2356.0   8 833.0 0.938 574.0, 8047.0 -0.47
SJL/J m 1133.0 1040.0   8 368.0 0.917 470.0, 3586.0 -0.78
SPRET/EiJ f 1269.0 385.0   7 146.0 0.303 698.0, 1766.0 -0.86
SPRET/EiJ m 846.0 392.0   6 160.0 0.463 426.0, 1478.0 -0.87
Tac:SW f 4351.0 1685.0   8 596.0 0.387 2590.0, 7017.0 0.11
Tac:SW m 3272.0 3270.0   8 1156.0 0.999 1113.0, 10889.0 -0.05


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 836.375 764.1305 2343.1154 0.0
129S1/SvImJ m 843.375 764.1305 2350.1154 0.0
129S6/SvEvTac f 390.75 764.1305 1897.4904 0.0
129S6/SvEvTac m 388.5 764.1305 1895.2404 0.0
129X1/SvJ f 427.375 764.1305 1934.1154 0.0
129X1/SvJ m 447.125 764.1305 1953.8654 0.0
A/J f 2035.5 764.1305 3542.2404 528.7596
A/J m 1540.125 764.1305 3046.8654 33.3846
BALB/cByJ f 5243.5 764.1305 6750.2404 3736.7596
BALB/cByJ m 6651.125 764.1305 8157.8654 5144.3846
BALB/cJ f 5138.5714 816.8899 6749.3447 3527.7982
BALB/cJ m 3865.125 764.1305 5371.8654 2358.3846
C3H/HeJ f 1374.125 764.1305 2880.8654 0.0
C3H/HeJ m 3470.375 764.1305 4977.1154 1963.6346
C57BL/6J f 7686.4286 816.8899 9297.2018 6075.6553
C57BL/6J m 4040.125 764.1305 5546.8654 2533.3846
CAST/EiJ f 7068.875 764.1305 8575.6154 5562.1346
CAST/EiJ m 9571.5 1080.6437 11702.3527 7440.6473
Crl:CD-1(ICR) f 4581.25 764.1305 6087.9904 3074.5096
Crl:CD-1(ICR) m 3349.125 764.1305 4855.8654 1842.3846
DBA/2J f 5723.625 764.1305 7230.3654 4216.8846
DBA/2J m 2766.25 764.1305 4272.9904 1259.5096
FVB/NJ f 11358.25 764.1305 12864.9904 9851.5096
FVB/NJ m 9028.5 764.1305 10535.2404 7521.7596
SJL/J f 2513.5 764.1305 4020.2404 1006.7596
SJL/J m 1133.25 764.1305 2639.9904 0.0
SPRET/EiJ f 1269.2857 816.8899 2880.059 0.0
SPRET/EiJ m 846.1667 882.3419 2586.0006 0.0
Tac:SW f 4351.125 764.1305 5857.8654 2844.3846
Tac:SW m 3271.5 764.1305 4778.2404 1764.7596


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 839.875 540.3219 1905.3014 0.0
129S6/SvEvTac both 389.625 540.3219 1455.0514 0.0
129X1/SvJ both 437.25 540.3219 1502.6764 0.0
A/J both 1787.8125 540.3219 2853.2389 722.3861
BALB/cByJ both 5947.3125 540.3219 7012.7389 4881.8861
BALB/cJ both 4501.8482 559.2863 5604.6693 3399.0272
C3H/HeJ both 2422.25 540.3219 3487.6764 1356.8236
C57BL/6J both 5863.2768 559.2863 6966.0978 4760.4557
CAST/EiJ both 8320.1875 661.7564 9625.063 7015.312
Crl:CD-1(ICR) both 3965.1875 540.3219 5030.6139 2899.7611
DBA/2J both 4244.9375 540.3219 5310.3639 3179.5111
FVB/NJ both 10193.375 540.3219 11258.8014 9127.9486
SJL/J both 1823.375 540.3219 2888.8014 757.9486
SPRET/EiJ both 1057.7262 601.2147 2243.2232 0.0
Tac:SW both 3811.3125 540.3219 4876.7389 2745.8861




  GWAS USING LINEAR MIXED MODELS