Project measure / variable:   Threadgill2   APAP_Glc_300_2

ID, description, units MPD:39647   APAP_Glc_300_2   serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen   [µg/mL]  2h  
acetaminophen study
Data set, strains Threadgill2   inbred   5 strains     sex: m     age: 6-8wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Threadgill2 - serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen 2h



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested5 strains
Mean of the strain means211   µg/mL
Median of the strain means199   µg/mL
SD of the strain means± 55.8
Coefficient of variation (CV)0.265
Min–max range of strain means131   –   270   µg/mL
Mean sample size per strain4.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 4 58704.007 14676.0017 3.5984 0.024
Residuals 19 77491.038 4078.4757


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
C3H/HeJ m 131.0 37.7   5 16.8 0.287 66.9, 166.0 -1.43
C57BL/6J m 258.0 60.0   5 26.8 0.232 184.0, 350.0 0.85
DBA/2J m 199.0 64.9   5 29.0 0.326 105.0, 288.0 -0.21
LP/J m 270.0 70.8   4 35.4 0.262 189.0, 334.0 1.06
NZW/LacJ m 196.0 79.9   5 35.8 0.408 97.5, 284.0 -0.27


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
C3H/HeJ m 131.38 28.5604 191.1576 71.6024
C57BL/6J m 258.4 28.5604 318.1776 198.6224
DBA/2J m 198.8 28.5604 258.5776 139.0224
LP/J m 270.25 31.9315 337.0833 203.4167
NZW/LacJ m 195.9 28.5604 255.6776 136.1224




  GWAS USING LINEAR MIXED MODELS