Project measure / variable:   Threadgill2   APAP300_2

ID, description, units MPD:39635   APAP300_2   serum acetaminophen (APAP), 300 mg/mL dose acetaminophen   [µg/mL]  2h  
acetaminophen study
Data set, strains Threadgill2   inbred   5 strains     sex: m     age: 6-8wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Threadgill2 - serum acetaminophen (APAP), 300 mg/mL dose acetaminophen 2h



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested5 strains
Mean of the strain means25.4   µg/mL
Median of the strain means24.2   µg/mL
SD of the strain means± 15.0
Coefficient of variation (CV)0.590
Min–max range of strain means10.9   –   46.3   µg/mL
Mean sample size per strain4.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 4 4038.0159 1009.504 7.4947 0.0008
Residuals 19 2559.2024 134.6949


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
C3H/HeJ m 10.9 4.33   5 1.94 0.396 3.91, 14.2 -0.97
C57BL/6J m 33.7 15.0   5 6.7 0.444 13.7, 55.0 0.55
DBA/2J m 24.2 10.5   5 4.7 0.434 11.5, 40.8 -0.08
LP/J m 46.3 17.3   4 8.63 0.373 21.1, 60.2 1.39
NZW/LacJ m 11.9 7.92   5 3.54 0.664 2.03, 23.5 -0.9


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
C3H/HeJ m 10.938 5.1903 21.8014 0.0746
C57BL/6J m 33.74 5.1903 44.6034 22.8766
DBA/2J m 24.24 5.1903 35.1034 13.3766
LP/J m 46.3 5.8029 58.4456 34.1544
NZW/LacJ m 11.928 5.1903 22.7914 1.0646




  GWAS USING LINEAR MIXED MODELS