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Project measure / variable:   Threadgill2   APAP_Sulf_50_1

ID, description, units MPD:39618   APAP_Sulf_50_1   serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen   [µg/mL]  1h  
acetaminophen study
Data set, strains Threadgill2   inbred   5 strains     sex: m     age: 6-8wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Threadgill2 - serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen 1h



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested5 strains
Mean of the strain means3.94   µg/mL
Median of the strain means3.41   µg/mL
SD of the strain means± 1.19
Coefficient of variation (CV)0.302
Min–max range of strain means2.78   –   5.60   µg/mL
Mean sample size per strain4.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 4 27.6937 6.9234 3.4465 0.028
Residuals 19 38.1676 2.0088


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
C3H/HeJ m 4.75 1.57   5 0.701 0.33 3.45, 6.75 0.68
C57BL/6J m 3.15 1.28   4 0.641 0.407 2.22, 5.02 -0.66
DBA/2J m 3.41 1.98   5 0.886 0.581 1.54, 6.68 -0.44
LP/J m 5.6 0.702   5 0.314 0.125 4.96, 6.69 1.4
NZW/LacJ m 2.78 1.2   5 0.537 0.432 1.39, 4.4 -0.97


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
C3H/HeJ m 4.75 0.6338 6.0767 3.4233
C57BL/6J m 3.1475 0.7087 4.6308 1.6642
DBA/2J m 3.412 0.6338 4.7387 2.0853
LP/J m 5.6 0.6338 6.9267 4.2733
NZW/LacJ m 2.778 0.6338 4.1047 1.4513




  GWAS USING LINEAR MIXED MODELS