Project measure / variable:   Threadgill2   APAP_Sulf_50_0.5

ID, description, units MPD:39617   APAP_Sulf_50_0.5   serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen   [µg/mL]  0.5h  
acetaminophen study
Data set, strains Threadgill2   inbred   5 strains     sex: m     age: 6-8wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Threadgill2 - serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen 0.5h



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested5 strains
Mean of the strain means6.01   µg/mL
Median of the strain means6.04   µg/mL
SD of the strain means± 1.01
Coefficient of variation (CV)0.168
Min–max range of strain means4.84   –   7.05   µg/mL
Mean sample size per strain4.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 4 18.7474 4.6868 0.4812 0.7492
Residuals 18 175.3143 9.7397


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
C3H/HeJ m 6.04 4.79   5 2.14 0.793 1.47, 13.6 0.03
C57BL/6J m 6.96 3.36   4 1.68 0.483 2.21, 9.41 0.94
DBA/2J m 5.15 0.984   4 0.492 0.191 3.78, 6.1 -0.85
LP/J m 7.05 1.48   5 0.663 0.211 5.29, 8.61 1.03
NZW/LacJ m 4.84 3.08   5 1.38 0.637 2.18, 10.0 -1.15


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
C3H/HeJ m 6.042 1.3957 8.9742 3.1098
C57BL/6J m 6.9575 1.5604 10.2358 3.6792
DBA/2J m 5.1525 1.5604 8.4308 1.8742
LP/J m 7.046 1.3957 9.9782 4.1138
NZW/LacJ m 4.84 1.3957 7.7722 1.9078




  GWAS USING LINEAR MIXED MODELS