Project measure / variable:   Threadgill2   APAP50_0.5

ID, description, units MPD:39610   APAP50_0.5   serum acetaminophen (APAP), 50 mg/mL dose acetaminophen   [µg/mL]  0.5h  
acetaminophen study
Data set, strains Threadgill2   inbred   5 strains     sex: m     age: 6-8wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Threadgill2 - serum acetaminophen (APAP), 50 mg/mL dose acetaminophen 0.5h



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested5 strains
Mean of the strain means4.27   µg/mL
Median of the strain means4.22   µg/mL
SD of the strain means± 1.24
Coefficient of variation (CV)0.289
Min–max range of strain means2.36   –   5.48   µg/mL
Mean sample size per strain4.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 4 29.5844 7.3961 0.699 0.6021
Residuals 19 201.049 10.5815


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
C3H/HeJ m 4.22 6.5   5 2.91 1.54 0.2, 15.4 -0.04
C57BL/6J m 5.25 2.03   4 1.01 0.387 2.94, 7.57 0.79
DBA/2J m 4.06 1.13   5 0.504 0.278 3.03, 5.69 -0.17
LP/J m 5.48 1.72   5 0.771 0.315 3.71, 8.03 0.98
NZW/LacJ m 2.36 0.834   5 0.373 0.354 1.67, 3.77 -1.55


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
C3H/HeJ m 4.22 1.4548 7.2648 1.1752
C57BL/6J m 5.245 1.6265 8.6492 1.8408
DBA/2J m 4.062 1.4548 7.1068 1.0172
LP/J m 5.476 1.4548 8.5208 2.4312
NZW/LacJ m 2.356 1.4548 5.4008 0.0




  GWAS USING LINEAR MIXED MODELS