Project measure / variable:   Berndt1   pct_res_mch3

ID, description, units MPD:34222   pct_res_mch3   airway resistance (as % of baseline, H2O pressure)   [%]  MCh challenge 3 mg/mL  
methacholine study
Data set, strains Berndt1   inbred   37 strains     sex: both     age: 9-12wks
Procedure ventilator
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  STRAIN COMPARISON PLOT
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Berndt1 - airway resistance (as % of baseline, H2O pressure) MCh challenge 3 mg/mL



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested36 strains33 strains
Mean of the strain means61.9   % 70.7   %
Median of the strain means54.2   % 61.9   %
SD of the strain means± 29.1 ± 35.9
Coefficient of variation (CV)0.469 0.508
Min–max range of strain means30.1   –   163   % 23.0   –   203   %
Mean sample size per strain8.6   mice 9.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 12702.4013 12702.4013 9.8138 0.0018
strain 31 554789.9568 17896.4502 13.8267 < 0.0001
sex:strain 31 69654.3582 2246.9148 1.736 0.0091
Residuals 509 658820.5147 1294.3429


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 47.5 15.9   9 5.3 0.335 28.0, 73.3 -0.5
129S1/SvImJ m 57.8 45.5   8 16.1 0.787 12.5, 130.0 -0.36
A/J f 127.0 35.8   10 11.3 0.281 74.3, 194.0 2.24
A/J m 149.0 73.7   9 24.6 0.496 73.0, 285.0 2.18
AKR/J f 40.7 14.9   9 4.97 0.367 18.5, 63.3 -0.73
AKR/J m 78.5 31.5   8 11.1 0.402 33.3, 140.0 0.22
BALB/cByJ f 54.2 34.1   8 12.0 0.629 9.6, 124.0 -0.27
BALB/cByJ m 56.0 26.3   8 9.31 0.47 15.2, 84.4 -0.41
BALB/cJ f 50.3 22.0   8 7.78 0.438 31.6, 92.1 -0.4
BALB/cJ m 73.3 26.6   10 8.42 0.363 25.5, 120.0 0.07
BPN/3J f 30.1 11.1   8 3.92 0.368 16.0, 46.2 -1.1
BTBR T+ Itpr3tf/J f 61.1 36.0   10 11.4 0.59 20.6, 130.0 -0.03
BTBR T+ Itpr3tf/J m 93.5 25.3   10 8.02 0.271 55.3, 130.0 0.63
BUB/BnJ f 43.5 32.3   9 10.8 0.741 1.2, 107.0 -0.63
BUB/BnJ m 36.7 15.9   10 5.02 0.433 21.4, 72.1 -0.95
C3H/HeJ f 40.4 19.0   10 6.01 0.471 19.2, 69.8 -0.74
C3H/HeJ m 50.7 20.2   9 6.72 0.397 20.0, 83.1 -0.56
C57BL/10J f 57.2 24.1   9 8.03 0.421 24.1, 108.0 -0.16
C57BL/10J m 92.3 25.5   10 8.05 0.276 50.0, 130.0 0.6
C57BL/6J f 31.5 16.1   8 5.7 0.512 13.0, 62.5 -1.05
C57BL/6J m 57.0 30.5   8 10.8 0.534 15.2, 120.0 -0.38
C57BLKS/J f 49.1 34.6   9 11.5 0.705 14.3, 136.0 -0.44
C57BLKS/J m 91.9 54.1   12 15.6 0.588 20.5, 206.0 0.59
C57BR/cdJ f 93.7 50.1   7 18.9 0.535 35.7, 188.0 1.09
C57BR/cdJ m 94.6 33.0   10 10.4 0.348 65.6, 171.0 0.66
C57L/J f 72.3 37.3   6 15.2 0.515 1.8, 112.0 0.36
C57L/J m 85.8 27.5   10 8.69 0.32 47.2, 133.0 0.42
CBA/J f 82.8 58.2   8 20.6 0.702 22.9, 207.0 0.72
CBA/J m 40.4 15.9   10 5.02 0.393 14.6, 65.9 -0.84
CE/J f 76.8 65.3   9 21.8 0.85 30.3, 234.0 0.51
CE/J m 47.1 16.6   9 5.55 0.353 20.5, 76.9 -0.66
DBA/1J f 54.2 37.4   9 12.5 0.691 13.6, 110.0 -0.27
DBA/1J m 63.8 42.0   10 13.3 0.659 23.3, 142.0 -0.19
DBA/2J f 46.6 19.2   10 6.06 0.411 19.4, 77.4 -0.53
DBA/2J m 63.5 33.6   10 10.6 0.53 35.1, 150.0 -0.2
FVB/NJ f 77.9 34.9   10 11.0 0.448 38.1, 124.0 0.55
FVB/NJ m 61.9 41.1   10 13.0 0.664 -4.9, 129.0 -0.25
I/LnJ f 128.0 42.2   9 14.1 0.33 75.0, 212.0 2.27
I/LnJ m 114.0 66.8   8 23.6 0.588 3.8, 202.0 1.21
KK/HlJ f 163.0 72.5   9 24.2 0.445 37.1, 284.0 3.48
KK/HlJ m 203.0 88.5   10 28.0 0.435 56.1, 346.0 3.68
LG/J f 36.3 25.4   10 8.03 0.7 -18.6, 71.0 -0.88
LG/J m 49.8 15.6   10 4.94 0.314 25.8, 71.0 -0.58
LP/J f 40.5 14.8   9 4.92 0.364 25.8, 72.4 -0.74
LP/J m 93.6 24.3   10 7.69 0.26 67.6, 146.0 0.64
MA/MyJ f 57.1 20.3   9 6.75 0.355 33.3, 88.1 -0.17
MRL/MpJ f 53.1 24.5   9 8.18 0.462 20.5, 106.0 -0.3
MRL/MpJ m 43.1 38.5   9 12.8 0.893 2.2, 124.0 -0.77
NOD/ShiLtJ f 81.1 44.6   9 14.9 0.55 37.1, 184.0 0.66
NOD/ShiLtJ m 91.5 50.3   9 16.8 0.55 30.0, 208.0 0.58
NON/ShiLtJ f 51.3 16.5   7 6.25 0.322 29.2, 69.6 -0.37
NON/ShiLtJ m 50.0 16.0   7 6.04 0.319 28.6, 67.9 -0.58
NZB/BlNJ m 23.0 14.6   10 4.62 0.634 -1.33
NZO/HlLtJ f 63.7 19.2   9 6.41 0.302 39.1, 103.0 0.06
NZW/LacJ f 39.2 19.6   8 6.92 0.499 15.2, 65.6 -0.78
NZW/LacJ m 52.5 18.3   10 5.8 0.349 27.6, 85.0 -0.51
P/J f 42.3 26.5   7 10.0 0.626 10.3, 80.6 -0.68
P/J m 36.3 25.1   8 8.86 0.691 6.1, 89.0 -0.96
PL/J f 88.8 42.9   9 14.3 0.483 33.3, 179.0 0.92
PL/J m 95.7 16.4   8 5.81 0.172 71.8, 114.0 0.7
PWD/PhJ f 57.3 20.5   6 8.35 0.357 30.4, 87.5 -0.16
RIIIS/J f 60.0 30.5   6 12.5 0.509 11.4, 92.6 -0.07
RIIIS/J m 43.8 15.2   9 5.08 0.348 25.5, 65.7 -0.75
SJL/J f 30.5 21.3   8 7.53 0.697 2.8, 65.5 -1.08
SJL/J m 64.2 26.2   9 8.74 0.408 28.6, 97.8 -0.18
SM/J f 56.7 35.0   10 11.1 0.618 21.7, 133.0 -0.18
SM/J m 40.1 25.1   8 8.87 0.626 6.6, 81.1 -0.85
SWR/J f 44.4 13.8   9 4.6 0.311 29.6, 65.5 -0.6
SWR/J m 39.6 10.2   10 3.23 0.258 18.8, 52.4 -0.87


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 47.4556 11.9923 71.0161 23.895
129S1/SvImJ m 57.8125 12.7198 82.8022 32.8228
A/J f 127.33 11.3769 149.6815 104.9785
A/J m 148.6556 11.9923 172.2161 125.095
AKR/J f 40.6556 11.9923 64.2161 17.095
AKR/J m 78.5375 12.7198 103.5272 53.5478
BALB/cByJ f 54.1875 12.7198 79.1772 29.1978
BALB/cByJ m 55.9625 12.7198 80.9522 30.9728
BALB/cJ f 50.2625 12.7198 75.2522 25.2728
BALB/cJ m 73.3 11.3769 95.6515 50.9485
BTBR T+ Itpr3tf/J f 61.11 11.3769 83.4615 38.7585
BTBR T+ Itpr3tf/J m 93.46 11.3769 115.8115 71.1085
BUB/BnJ f 43.5333 11.9923 67.0939 19.9728
BUB/BnJ m 36.69 11.3769 59.0415 14.3385
C3H/HeJ f 40.39 11.3769 62.7415 18.0385
C3H/HeJ m 50.7222 11.9923 74.2828 27.1617
C57BL/10J f 57.2222 11.9923 80.7828 33.6617
C57BL/10J m 92.26 11.3769 114.6115 69.9085
C57BL/6J f 31.5 12.7198 56.4897 6.5103
C57BL/6J m 57.0375 12.7198 82.0272 32.0478
C57BLKS/J f 49.0556 11.9923 72.6161 25.495
C57BLKS/J m 91.875 10.3857 112.279 71.471
C57BR/cdJ f 93.7 13.598 120.4152 66.9848
C57BR/cdJ m 94.64 11.3769 116.9915 72.2885
C57L/J f 72.3333 14.6875 101.189 43.4777
C57L/J m 85.77 11.3769 108.1215 63.4185
CBA/J f 82.8375 12.7198 107.8272 57.8478
CBA/J m 40.39 11.3769 62.7415 18.0385
CE/J f 76.8444 11.9923 100.405 53.2839
CE/J m 47.0889 11.9923 70.6494 23.5283
DBA/1J f 54.1889 11.9923 77.7494 30.6283
DBA/1J m 63.76 11.3769 86.1115 41.4085
DBA/2J f 46.61 11.3769 68.9615 24.2585
DBA/2J m 63.47 11.3769 85.8215 41.1185
FVB/NJ f 77.89 11.3769 100.2415 55.5385
FVB/NJ m 61.87 11.3769 84.2215 39.5185
I/LnJ f 127.8111 11.9923 151.3717 104.2506
I/LnJ m 113.5625 12.7198 138.5522 88.5728
KK/HlJ f 162.8444 11.9923 186.405 139.2839
KK/HlJ m 203.47 11.3769 225.8215 181.1185
LG/J f 36.32 11.3769 58.6715 13.9685
LG/J m 49.79 11.3769 72.1415 27.4385
LP/J f 40.5444 11.9923 64.105 16.9839
LP/J m 93.6 11.3769 115.9515 71.2485
MRL/MpJ f 53.0889 11.9923 76.6494 29.5283
MRL/MpJ m 43.1444 11.9923 66.705 19.5839
NOD/ShiLtJ f 81.0889 11.9923 104.6494 57.5283
NOD/ShiLtJ m 91.4778 11.9923 115.0383 67.9172
NON/ShiLtJ f 51.3429 13.598 78.058 24.6277
NON/ShiLtJ m 50.0286 13.598 76.7437 23.3134
NZW/LacJ f 39.2375 12.7198 64.2272 14.2478
NZW/LacJ m 52.45 11.3769 74.8015 30.0985
P/J f 42.3286 13.598 69.0437 15.6134
P/J m 36.275 12.7198 61.2647 11.2853
PL/J f 88.7556 11.9923 112.3161 65.195
PL/J m 95.7125 12.7198 120.7022 70.7228
RIIIS/J f 59.9833 14.6875 88.839 31.1277
RIIIS/J m 43.7556 11.9923 67.3161 20.195
SJL/J f 30.55 12.7198 55.5397 5.5603
SJL/J m 64.2444 11.9923 87.805 40.6839
SM/J f 56.66 11.3769 79.0115 34.3085
SM/J m 40.0625 12.7198 65.0522 15.0728
SWR/J f 44.3667 11.9923 67.9272 20.8061
SWR/J m 39.59 11.3769 61.9415 17.2385


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 52.634 8.7408 69.8066 35.4615
A/J both 137.9928 8.2651 154.2308 121.7548
AKR/J both 59.5965 8.7408 76.7691 42.424
BALB/cByJ both 55.075 8.9942 72.7454 37.4046
BALB/cJ both 61.7812 8.5327 78.5449 45.0176
BTBR T+ Itpr3tf/J both 77.285 8.0447 93.0899 61.4801
BUB/BnJ both 40.1117 8.2651 56.3497 23.8737
C3H/HeJ both 45.5561 8.2651 61.7941 29.3181
C57BL/10J both 74.7411 8.2651 90.9791 58.5031
C57BL/6J both 44.2687 8.9942 61.9392 26.5983
C57BLKS/J both 70.4653 7.9322 86.0491 54.8814
C57BR/cdJ both 94.17 8.8648 111.5861 76.7539
C57L/J both 79.0517 9.2892 97.3016 60.8017
CBA/J both 61.6137 8.5327 78.3774 44.8501
CE/J both 61.9667 8.4799 78.6265 45.3068
DBA/1J both 58.9744 8.2651 75.2124 42.7365
DBA/2J both 55.04 8.0447 70.8449 39.2351
FVB/NJ both 69.88 8.0447 85.6849 54.0751
I/LnJ both 120.6868 8.7408 137.8594 103.5143
KK/HlJ both 183.1572 8.2651 199.3952 166.9192
LG/J both 43.055 8.0447 58.8599 27.2501
LP/J both 67.0722 8.2651 83.3102 50.8342
MRL/MpJ both 48.1167 8.4799 64.7765 31.4568
NOD/ShiLtJ both 86.2833 8.4799 102.9432 69.6235
NON/ShiLtJ both 50.6857 9.6153 69.5762 31.7952
NZW/LacJ both 45.8438 8.5327 62.6074 29.0801
P/J both 39.3018 9.3099 57.5924 21.0112
PL/J both 92.234 8.7408 109.4066 75.0615
RIIIS/J both 51.8694 9.4808 70.4957 33.2432
SJL/J both 47.3972 8.7408 64.5698 30.2247
SM/J both 48.3613 8.5327 65.1249 31.5976
SWR/J both 41.9783 8.2651 58.2163 25.7403




  GWAS USING LINEAR MIXED MODELS