Project measure / variable:   Berndt1   pct_res_mch1

ID, description, units MPD:34221   pct_res_mch1   airway resistance (as % of baseline, H2O pressure)   [%]  MCh challenge 1 mg/mL  
methacholine study
Data set, strains Berndt1   inbred   37 strains     sex: both     age: 9-12wks
Procedure ventilator
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  STRAIN COMPARISON PLOT
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Berndt1 - airway resistance (as % of baseline, H2O pressure) MCh challenge 1 mg/mL



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested36 strains33 strains
Mean of the strain means21.6   % 21.5   %
Median of the strain means18.4   % 19.0   %
SD of the strain means± 10.3 ± 11.0
Coefficient of variation (CV)0.479 0.512
Min–max range of strain means9.51   –   48.5   % 6.32   –   58.4   %
Mean sample size per strain8.6   mice 9.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 1.4621 1.4621 0.0046 0.9457
strain 31 36963.6828 1192.3769 3.7879 < 0.0001
sex:strain 31 23026.883 742.8027 2.3597 0.0001
Residuals 509 160225.179 314.7842


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 11.1 3.83   9 1.28 0.346 6.7, 18.2 -1.01
129S1/SvImJ m 7.8 10.6   8 3.75 1.36 -12.5, 25.0 -1.24
A/J f 39.8 38.1   10 12.0 0.957 14.3, 143.0 1.76
A/J m 58.4 17.9   9 5.97 0.307 37.3, 90.2 3.34
AKR/J f 14.8 13.3   9 4.42 0.897 -3.7, 41.7 -0.65
AKR/J m 44.9 22.4   8 7.9 0.498 20.3, 84.9 2.12
BALB/cByJ f 23.2 21.1   8 7.47 0.911 7.7, 73.8 0.16
BALB/cByJ m 21.4 13.1   8 4.62 0.611 3.3, 41.5 -0.01
BALB/cJ f 34.4 46.2   8 16.3 1.34 1.8, 137.0 1.24
BALB/cJ m 24.1 11.2   10 3.53 0.463 10.9, 43.6 0.23
BPN/3J f 10.2 11.1   8 3.92 1.09 -1.1
BTBR T+ Itpr3tf/J f 25.1 13.0   10 4.1 0.516 9.4, 51.1 0.34
BTBR T+ Itpr3tf/J m 27.2 19.0   10 6.01 0.698 5.3, 69.6 0.51
BUB/BnJ f 18.0 17.0   9 5.66 0.942 -0.35
BUB/BnJ m 13.2 13.0   10 4.1 0.98 1.5, 47.3 -0.76
C3H/HeJ f 15.7 5.08   10 1.61 0.324 7.7, 23.7 -0.57
C3H/HeJ m 25.6 20.8   9 6.93 0.812 3.4, 72.9 0.37
C57BL/10J f 14.1 10.1   9 3.37 0.718 -0.72
C57BL/10J m 15.1 8.69   10 2.75 0.577 2.6, 31.3 -0.58
C57BL/6J f 10.4 6.15   8 2.17 0.593 3.7, 23.3 -1.08
C57BL/6J m 24.1 16.9   8 5.99 0.703 9.3, 62.5 0.23
C57BLKS/J f 15.7 5.91   9 1.97 0.377 5.7, 25.0 -0.57
C57BLKS/J m 14.9 13.4   12 3.87 0.9 -0.6
C57BR/cdJ f 48.5 28.0   7 10.6 0.577 10.7, 94.4 2.6
C57BR/cdJ m 20.4 6.73   10 2.13 0.329 10.3, 29.2 -0.1
C57L/J f 14.0 10.2   6 4.18 0.729 -0.73
C57L/J m 29.1 14.4   10 4.55 0.495 7.7, 56.3 0.69
CBA/J f 39.8 25.8   8 9.14 0.65 10.8, 86.5 1.76
CBA/J m 12.2 13.5   10 4.26 1.11 2.2, 47.7 -0.85
CE/J f 30.1 35.5   9 11.8 1.18 0.82
CE/J m 18.7 11.7   9 3.9 0.625 2.3, 37.5 -0.26
DBA/1J f 22.0 16.7   9 5.57 0.76 2.0, 52.6 0.04
DBA/1J m 15.1 9.54   10 3.02 0.631 1.8, 36.8 -0.58
DBA/2J f 12.3 6.46   10 2.04 0.524 -0.9
DBA/2J m 16.1 9.9   10 3.13 0.614 3.6, 38.6 -0.49
FVB/NJ f 24.9 19.2   10 6.08 0.77 0.32
FVB/NJ m 15.4 14.5   10 4.6 0.944 -7.3, 45.2 -0.56
I/LnJ f 28.2 19.8   9 6.61 0.704 8.6, 76.2 0.64
I/LnJ m 16.8 14.9   8 5.28 0.89 -11.3, 36.5 -0.43
KK/HlJ f 35.1 24.9   9 8.31 0.71 -2.1, 66.7 1.31
KK/HlJ m 36.3 15.5   10 4.9 0.427 12.2, 61.3 1.34
LG/J f 21.3 22.8   10 7.21 1.07 -9.3, 65.2 -0.03
LG/J m 38.8 19.0   10 6.02 0.491 14.8, 70.0 1.56
LP/J f 11.3 6.31   9 2.1 0.561 4.0, 25.9 -0.99
LP/J m 22.4 9.34   10 2.95 0.418 9.7, 43.8 0.08
MA/MyJ f 13.6 9.11   9 3.04 0.669 2.4, 31.0 -0.77
MRL/MpJ f 22.0 14.8   9 4.92 0.672 2.9, 45.7 0.04
MRL/MpJ m 14.3 10.9   9 3.65 0.766 2.2, 34.0 -0.66
NOD/ShiLtJ f 17.4 22.8   9 7.61 1.31 -3.6, 75.0 -0.4
NOD/ShiLtJ m 25.8 14.4   9 4.79 0.556 7.5, 47.4 0.39
NON/ShiLtJ f 18.5 14.1   7 5.34 0.766 6.5, 46.3 -0.3
NON/ShiLtJ m 26.8 43.5   7 16.4 1.62 -1.9, 124.0 0.48
NZB/BlNJ m 6.32 7.59   10 2.4 1.2 -8.2, 20.0 -1.38
NZO/HlLtJ f 31.1 24.7   9 8.23 0.793 9.1, 74.3 0.92
NZW/LacJ f 19.1 8.6   8 3.04 0.45 8.7, 32.1 -0.24
NZW/LacJ m 27.4 17.3   10 5.46 0.63 -7.9, 47.8 0.53
P/J f 18.4 9.49   7 3.59 0.516 7.1, 28.8 -0.31
P/J m 14.0 14.2   8 5.02 1.02 -2.1, 45.2 -0.68
PL/J f 19.7 10.3   9 3.44 0.524 3.9, 37.0 -0.18
PL/J m 25.8 16.4   8 5.81 0.638 11.3, 59.2 0.39
PWD/PhJ f 12.9 8.47   6 3.46 0.657 4.3, 25.6 -0.84
RIIIS/J f 44.8 40.1   6 16.4 0.895 -2.9, 106.0 2.25
RIIIS/J m 19.0 11.2   9 3.73 0.588 4.7, 35.8 -0.23
SJL/J f 12.2 17.5   8 6.2 1.44 -5.6, 52.3 -0.91
SJL/J m 13.3 11.2   9 3.75 0.848 -7.7, 26.7 -0.75
SM/J f 17.4 15.4   10 4.87 0.884 2.0, 56.4 -0.4
SM/J m 8.16 9.17   8 3.24 1.12 -1.21
SWR/J f 9.51 6.43   9 2.14 0.676 -1.17
SWR/J m 11.9 6.9   10 2.18 0.579 -0.87


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 11.0889 5.9141 22.7078 0.0
129S1/SvImJ m 7.8 6.2728 20.1238 0.0
A/J f 39.76 5.6106 50.7827 28.7373
A/J m 58.4222 5.9141 70.0412 46.8033
AKR/J f 14.7889 5.9141 26.4078 3.1699
AKR/J m 44.8625 6.2728 57.1863 32.5387
BALB/cByJ f 23.1875 6.2728 35.5113 10.8637
BALB/cByJ m 21.3875 6.2728 33.7113 9.0637
BALB/cJ f 34.4375 6.2728 46.7613 22.1137
BALB/cJ m 24.13 5.6106 35.1527 13.1073
BTBR T+ Itpr3tf/J f 25.09 5.6106 36.1127 14.0673
BTBR T+ Itpr3tf/J m 27.22 5.6106 38.2427 16.1973
BUB/BnJ f 18.0222 5.9141 29.6412 6.4033
BUB/BnJ m 13.24 5.6106 24.2627 2.2173
C3H/HeJ f 15.66 5.6106 26.6827 4.6373
C3H/HeJ m 25.6222 5.9141 37.2412 14.0033
C57BL/10J f 14.0667 5.9141 25.6856 2.4477
C57BL/10J m 15.07 5.6106 26.0927 4.0473
C57BL/6J f 10.3625 6.2728 22.6863 0.0
C57BL/6J m 24.1 6.2728 36.4238 11.7762
C57BLKS/J f 15.6778 5.9141 27.2967 4.0588
C57BLKS/J m 14.9167 5.1217 24.979 4.8544
C57BR/cdJ f 48.4714 6.7059 61.6461 35.2968
C57BR/cdJ m 20.44 5.6106 31.4627 9.4173
C57L/J f 14.05 7.2432 28.2803 0.0
C57L/J m 29.06 5.6106 40.0827 18.0373
CBA/J f 39.775 6.2728 52.0988 27.4512
CBA/J m 12.15 5.6106 23.1727 1.1273
CE/J f 30.1111 5.9141 41.7301 18.4922
CE/J m 18.7111 5.9141 30.3301 7.0922
DBA/1J f 21.9889 5.9141 33.6078 10.3699
DBA/1J m 15.12 5.6106 26.1427 4.0973
DBA/2J f 12.32 5.6106 23.3427 1.2973
DBA/2J m 16.11 5.6106 27.1327 5.0873
FVB/NJ f 24.95 5.6106 35.9727 13.9273
FVB/NJ m 15.41 5.6106 26.4327 4.3873
I/LnJ f 28.1667 5.9141 39.7856 16.5477
I/LnJ m 16.7875 6.2728 29.1113 4.4637
KK/HlJ f 35.1444 5.9141 46.7634 23.5255
KK/HlJ m 36.28 5.6106 47.3027 25.2573
LG/J f 21.31 5.6106 32.3327 10.2873
LG/J m 38.77 5.6106 49.7927 27.7473
LP/J f 11.2556 5.9141 22.8745 0.0
LP/J m 22.36 5.6106 33.3827 11.3373
MRL/MpJ f 21.9778 5.9141 33.5967 10.3588
MRL/MpJ m 14.2889 5.9141 25.9078 2.6699
NOD/ShiLtJ f 17.3556 5.9141 28.9745 5.7366
NOD/ShiLtJ m 25.8333 5.9141 37.4523 14.2144
NON/ShiLtJ f 18.4571 6.7059 31.6318 5.2825
NON/ShiLtJ m 26.8429 6.7059 40.0175 13.6682
NZW/LacJ f 19.1125 6.2728 31.4363 6.7887
NZW/LacJ m 27.44 5.6106 38.4627 16.4173
P/J f 18.4 6.7059 31.5747 5.2253
P/J m 13.975 6.2728 26.2988 1.6512
PL/J f 19.7222 5.9141 31.3412 8.1033
PL/J m 25.775 6.2728 38.0988 13.4512
RIIIS/J f 44.8333 7.2432 59.0636 30.6031
RIIIS/J m 19.0333 5.9141 30.6523 7.4144
SJL/J f 12.225 6.2728 24.5488 0.0
SJL/J m 13.2556 5.9141 24.8745 1.6366
SM/J f 17.43 5.6106 28.4527 6.4073
SM/J m 8.1625 6.2728 20.4863 0.0
SWR/J f 9.5111 5.9141 21.1301 0.0
SWR/J m 11.91 5.6106 22.9327 0.8873


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 9.4444 4.3106 17.9131 0.9757
A/J both 49.0911 4.076 57.0989 41.0833
AKR/J both 29.8257 4.3106 38.2944 21.357
BALB/cByJ both 22.2875 4.4355 31.0017 13.5733
BALB/cJ both 29.2837 4.2079 37.5508 21.0167
BTBR T+ Itpr3tf/J both 26.155 3.9673 33.9492 18.3608
BUB/BnJ both 15.6311 4.076 23.6389 7.6233
C3H/HeJ both 20.6411 4.076 28.6489 12.6333
C57BL/10J both 14.5683 4.076 22.5761 6.5605
C57BL/6J both 17.2312 4.4355 25.9455 8.517
C57BLKS/J both 15.2972 3.9118 22.9824 7.612
C57BR/cdJ both 34.4557 4.3717 43.0445 25.8669
C57L/J both 21.555 4.581 30.555 12.555
CBA/J both 25.9625 4.2079 34.2295 17.6955
CE/J both 24.4111 4.1819 32.627 16.1953
DBA/1J both 18.5544 4.076 26.5623 10.5466
DBA/2J both 14.215 3.9673 22.0092 6.4208
FVB/NJ both 20.18 3.9673 27.9742 12.3858
I/LnJ both 22.4771 4.3106 30.9458 14.0084
KK/HlJ both 35.7122 4.076 43.72 27.7044
LG/J both 30.04 3.9673 37.8342 22.2458
LP/J both 16.8078 4.076 24.8156 8.8
MRL/MpJ both 18.1333 4.1819 26.3492 9.9175
NOD/ShiLtJ both 21.5944 4.1819 29.8103 13.3786
NON/ShiLtJ both 22.65 4.7418 31.9659 13.3341
NZW/LacJ both 23.2762 4.2079 31.5433 15.0092
P/J both 16.1875 4.5912 25.2076 7.1674
PL/J both 22.7486 4.3106 31.2173 14.2799
RIIIS/J both 31.9333 4.6755 41.1189 22.7477
SJL/J both 12.7403 4.3106 21.209 4.2716
SM/J both 12.7963 4.2079 21.0633 4.5292
SWR/J both 10.7106 4.076 18.7184 2.7027




  GWAS USING LINEAR MIXED MODELS