Project measure / variable:   Shockley1   HDL_fat

ID, description, units MPD:33437   HDL_fat   HDL cholesterol (HDL)   [mg/dL]  high-fat diet  
high-fat diet study
Data set, strains Shockley1   inbred   10 strains     sex: both     age: 10-13wks
Procedure lipid profile
Ontology mappings

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  STRAIN COMPARISON PLOT
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Shockley1 - HDL cholesterol (HDL) high-fat diet



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means106   mg/dL 135   mg/dL
Median of the strain means95.2   mg/dL 120   mg/dL
SD of the strain means± 41.7 ± 51.2
Coefficient of variation (CV)0.394 0.379
Min–max range of strain means46.2   –   183   mg/dL 78.8   –   229   mg/dL
Mean sample size per strain5.0   mice 5.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 19410.129 19410.129 74.4368 < 0.0001
strain 9 169695.0726 18855.0081 72.308 < 0.0001
sex:strain 9 13870.9471 1541.2163 5.9105 < 0.0001
Residuals 78 20339.262 260.7598


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 165.0 25.7   4 12.9 0.156 131.0, 193.0 1.42
129S1/SvImJ m 185.0 14.3   5 6.41 0.0776 170.0, 203.0 0.98
A/J f 113.0 21.0   5 9.39 0.186 84.8, 143.0 0.17
A/J m 105.0 6.2   5 2.77 0.0593 98.9, 114.0 -0.58
BALB/cJ f 94.1 2.78   5 1.24 0.0296 91.1, 96.9 -0.28
BALB/cJ m 95.8 14.1   5 6.3 0.147 79.1, 114.0 -0.76
C3H/HeJ f 95.1 12.4   5 5.54 0.13 81.5, 115.0 -0.26
C3H/HeJ m 134.0 15.6   5 6.98 0.116 110.0, 150.0 -0.02
C57BL/6J f 64.4 4.78   5 2.14 0.0743 57.8, 71.1 -0.99
C57BL/6J m 94.5 6.0   5 2.69 0.0635 85.3, 100.0 -0.79
DBA/2J f 95.3 6.71   5 3.0 0.0704 88.5, 103.0 -0.25
DBA/2J m 148.0 17.8   5 7.95 0.12 120.0, 166.0 0.26
I/LnJ f 46.2 7.91   5 3.54 0.171 38.6, 58.4 -1.43
I/LnJ m 78.8 11.6   5 5.17 0.147 65.4, 92.4 -1.1
MRL/MpJ-Faslpr/J f 116.0 5.29   5 2.37 0.0456 109.0, 123.0 0.24
MRL/MpJ-Faslpr/J m 188.0 18.4   5 8.24 0.0982 166.0, 215.0 1.04
NZB/BlNJ f 183.0 29.2   5 13.1 0.159 150.0, 218.0 1.85
NZB/BlNJ m 229.0 33.4   4 16.7 0.146 182.0, 259.0 1.84
SM/J f 85.9 14.4   5 6.43 0.167 68.6, 108.0 -0.48
SM/J m 90.3 20.5   5 9.16 0.227 65.0, 120.0 -0.87


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 165.25 8.074 181.3242 149.1758
129S1/SvImJ m 184.8 7.2216 199.1772 170.4228
A/J f 112.96 7.2216 127.3372 98.5828
A/J m 104.66 7.2216 119.0372 90.2828
BALB/cJ f 94.14 7.2216 108.5172 79.7628
BALB/cJ m 95.76 7.2216 110.1372 81.3828
C3H/HeJ f 95.1 7.2216 109.4772 80.7228
C3H/HeJ m 134.0 7.2216 148.3772 119.6228
C57BL/6J f 64.36 7.2216 78.7372 49.9828
C57BL/6J m 94.48 7.2216 108.8572 80.1028
DBA/2J f 95.32 7.2216 109.6972 80.9428
DBA/2J m 147.8 7.2216 162.1772 133.4228
I/LnJ f 46.16 7.2216 60.5372 31.7828
I/LnJ m 78.78 7.2216 93.1572 64.4028
MRL/MpJ-Faslpr/J f 116.0 7.2216 130.3772 101.6228
MRL/MpJ-Faslpr/J m 187.6 7.2216 201.9772 173.2228
NZB/BlNJ f 183.4 7.2216 197.7772 169.0228
NZB/BlNJ m 229.0 8.074 245.0742 212.9258
SM/J f 85.92 7.2216 100.2972 71.5428
SM/J m 90.32 7.2216 104.6972 75.9428


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 175.025 5.4162 185.8079 164.2421
A/J both 108.81 5.1065 118.9762 98.6438
BALB/cJ both 94.95 5.1065 105.1162 84.7838
C3H/HeJ both 114.55 5.1065 124.7162 104.3838
C57BL/6J both 79.42 5.1065 89.5862 69.2538
DBA/2J both 121.56 5.1065 131.7262 111.3938
I/LnJ both 62.47 5.1065 72.6362 52.3038
MRL/MpJ-Faslpr/J both 151.8 5.1065 161.9662 141.6338
NZB/BlNJ both 206.2 5.4162 216.9829 195.4171
SM/J both 88.12 5.1065 98.2862 77.9538




  GWAS USING LINEAR MIXED MODELS