Project measure / variable:   Shockley1   T4

ID, description, units MPD:33410   T4   thyroxine (T4)   [µg/dL]  control diet  
high-fat diet study
Data set, strains Shockley1   inbred   10 strains     sex: both     age: 10-13wks
Procedure metabolic panel
Ontology mappings

  STRAIN COMPARISON PLOT
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Shockley1 - thyroxine (T4) control diet



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means5.92   µg/dL 5.62   µg/dL
Median of the strain means5.81   µg/dL 5.30   µg/dL
SD of the strain means± 1.41 ± 1.27
Coefficient of variation (CV)0.237 0.226
Min–max range of strain means3.20   –   8.54   µg/dL 4.24   –   8.08   µg/dL
Mean sample size per strain4.9   mice 5.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 5.524 5.524 4.2787 0.042
strain 9 113.8746 12.6527 9.8004 < 0.0001
sex:strain 9 23.7215 2.6357 2.0415 0.0458
Residuals 76 98.1195 1.291


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 5.7 0.612   5 0.274 0.107 4.8, 6.4 -0.16
129S1/SvImJ m 7.6 0.644   5 0.288 0.0848 7.0, 8.6 1.56
A/J f 6.96 0.929   5 0.415 0.133 5.6, 8.1 0.74
A/J m 5.9 0.663   5 0.297 0.112 5.2, 6.9 0.22
BALB/cJ f 6.76 1.24   5 0.556 0.184 5.0, 8.0 0.6
BALB/cJ m 5.58 0.993   5 0.444 0.178 4.6, 6.9 -0.03
C3H/HeJ f 8.54 1.04   5 0.463 0.121 7.2, 9.7 1.87
C3H/HeJ m 8.08 0.841   5 0.376 0.104 6.8, 9.1 1.94
C57BL/6J f 5.06 0.472   5 0.211 0.0933 4.5, 5.8 -0.61
C57BL/6J m 5.24 0.74   5 0.331 0.141 4.0, 5.9 -0.3
DBA/2J f 5.92 1.1   5 0.492 0.186 4.6, 7.6 0.0
DBA/2J m 5.36 3.05   5 1.36 0.568 0.1, 7.7 -0.21
I/LnJ f 3.2 0.707   2   0.5 0.221 2.7, 3.7 -1.93
I/LnJ m 4.24 0.55   5 0.246 0.13 3.6, 5.1 -1.09
MRL/MpJ-Faslpr/J f 5.58 1.09   4 0.544 0.195 4.5, 6.9 -0.24
MRL/MpJ-Faslpr/J m 4.62 0.712   5 0.318 0.154 3.6, 5.5 -0.79
NZB/BlNJ f 5.12 0.396   5 0.177 0.0774 4.5, 5.5 -0.57
NZB/BlNJ m 4.82 1.61   5 0.719 0.334 3.2, 6.7 -0.63
SM/J f 6.34 1.37   5 0.611 0.216 4.9, 8.5 0.3
SM/J m 4.78 0.657   5 0.294 0.138 3.8, 5.6 -0.66


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 5.7 0.5081 6.7121 4.6879
129S1/SvImJ m 7.6 0.5081 8.6121 6.5879
A/J f 6.96 0.5081 7.9721 5.9479
A/J m 5.9 0.5081 6.9121 4.8879
BALB/cJ f 6.76 0.5081 7.7721 5.7479
BALB/cJ m 5.58 0.5081 6.5921 4.5679
C3H/HeJ f 8.54 0.5081 9.5521 7.5279
C3H/HeJ m 8.08 0.5081 9.0921 7.0679
C57BL/6J f 5.06 0.5081 6.0721 4.0479
C57BL/6J m 5.24 0.5081 6.2521 4.2279
DBA/2J f 5.92 0.5081 6.9321 4.9079
DBA/2J m 5.36 0.5081 6.3721 4.3479
I/LnJ f 3.2 0.8034 4.8002 1.5998
I/LnJ m 4.24 0.5081 5.2521 3.2279
MRL/MpJ-Faslpr/J f 5.575 0.5681 6.7065 4.4435
MRL/MpJ-Faslpr/J m 4.62 0.5081 5.6321 3.6079
NZB/BlNJ f 5.12 0.5081 6.1321 4.1079
NZB/BlNJ m 4.82 0.5081 5.8321 3.8079
SM/J f 6.34 0.5081 7.3521 5.3279
SM/J m 4.78 0.5081 5.7921 3.7679


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 6.65 0.3593 7.3656 5.9344
A/J both 6.43 0.3593 7.1456 5.7144
BALB/cJ both 6.17 0.3593 6.8856 5.4544
C3H/HeJ both 8.31 0.3593 9.0256 7.5944
C57BL/6J both 5.15 0.3593 5.8656 4.4344
DBA/2J both 5.64 0.3593 6.3556 4.9244
I/LnJ both 3.72 0.4753 4.6667 2.7733
MRL/MpJ-Faslpr/J both 5.0975 0.3811 5.8565 4.3385
NZB/BlNJ both 4.97 0.3593 5.6856 4.2544
SM/J both 5.56 0.3593 6.2756 4.8444




  GWAS USING LINEAR MIXED MODELS