Project measure / variable:   Palmer2   methactivity1_OFT

ID, description, units MPD:30005   methactivity1_OFT   change in activity after methamphetamine, day3-day1   [cm]  
methamphetamine study
Data set, strains Palmer2   B6.A consomic w/par   21 strains     sex: both     age: 7-16wks
Procedure open field test
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  STRAIN COMPARISON PLOT
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Palmer2 - change in activity after methamphetamine, day3-day1



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested21 strains21 strains
Mean of the strain means10992   cm 11318   cm
Median of the strain means11379   cm 11546   cm
SD of the strain means± 4148 ± 3574
Coefficient of variation (CV)0.377 0.316
Min–max range of strain means1846   –   18349   cm 3574   –   17243   cm
Mean sample size per strain10.4   mice 11.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 64904963.1647 64904963.1647 2.2145 0.1374
strain 20 6369459768.418 318472988.4209 10.8658 < 0.0001
sex:strain 20 848178609.2685 42408930.4634 1.4469 0.0952
Residuals 497 14566841133.6014 29309539.5042


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 1846.0 2468.0   9 823.0 1.34 -1172.0, 6558.0 -2.2
A/J m 3574.0 4580.0   10 1448.0 1.28 -803.0, 13448.0 -2.17
B6.A-Chr1 f 15616.0 10512.0   4 5256.0 0.673 2920.0, 28602.0 1.11
B6.A-Chr1 m 6696.0 3748.0   6 1530.0 0.56 2670.0, 11348.0 -1.29
B6.A-Chr10 f 17014.0 7303.0   13 2026.0 0.429 2177.0, 26191.0 1.45
B6.A-Chr10 m 17243.0 2340.0   16 585.0 0.136 12250.0, 20770.0 1.66
B6.A-Chr11 f 6085.0 4137.0   14 1106.0 0.68 -658.0, 13071.0 -1.18
B6.A-Chr11 m 6588.0 4481.0   23 934.0 0.68 -874.0, 15466.0 -1.32
B6.A-Chr12 f 18349.0 4369.0   15 1128.0 0.238 12292.0, 28552.0 1.77
B6.A-Chr12 m 15451.0 4908.0   34 842.0 0.318 5742.0, 26752.0 1.16
B6.A-Chr14 f 12221.0 5860.0   9 1953.0 0.48 3149.0, 21953.0 0.3
B6.A-Chr14 m 11003.0 5220.0   5 2335.0 0.474 4877.0, 17286.0 -0.09
B6.A-Chr15 f 13456.0 6661.0   10 2107.0 0.495 6301.0, 28113.0 0.59
B6.A-Chr15 m 15752.0 3204.0   13 889.0 0.203 11659.0, 21926.0 1.24
B6.A-Chr16 f 6160.0 4184.0   13 1160.0 0.679 -27.0, 13437.0 -1.16
B6.A-Chr16 m 7899.0 4458.0   9 1486.0 0.564 1320.0, 15679.0 -0.96
B6.A-Chr17 f 12010.0 5392.0   3 3113.0 0.449 6673.0, 17455.0 0.25
B6.A-Chr17 m 16459.0 4110.0   9 1370.0 0.25 9964.0, 22032.0 1.44
B6.A-Chr18 f 10027.0 2267.0   5 1014.0 0.226 6588.0, 12707.0 -0.23
B6.A-Chr18 m 12851.0 4964.0   9 1655.0 0.386 3272.0, 17835.0 0.43
B6.A-Chr19 f 9604.0 6974.0   10 2205.0 0.726 1231.0, 22023.0 -0.33
B6.A-Chr19 m 14057.0 3724.0   10 1178.0 0.265 6527.0, 18582.0 0.77
B6.A-Chr2 f 10663.0 3531.0   10 1117.0 0.331 3998.0, 17313.0 -0.08
B6.A-Chr2 m 12708.0 4373.0   10 1383.0 0.344 6389.0, 21294.0 0.39
B6.A-Chr3 f 15392.0 6028.0   8 2131.0 0.392 5410.0, 23698.0 1.06
B6.A-Chr3 m 13915.0 7558.0   14 2020.0 0.543 -924.0, 27010.0 0.73
B6.A-Chr4 f 8114.0 4251.0   10 1344.0 0.524 524.0, 14234.0 -0.69
B6.A-Chr4 m 10150.0 4279.0   9 1426.0 0.422 6300.0, 18664.0 -0.33
B6.A-Chr5 f 13159.0 5282.0   14 1412.0 0.401 3291.0, 21388.0 0.52
B6.A-Chr5 m 8253.0 5649.0   10 1786.0 0.684 -2072.0, 19005.0 -0.86
B6.A-Chr6 f 11379.0 7640.0   10 2416.0 0.671 1552.0, 26981.0 0.09
B6.A-Chr6 m 10372.0 5364.0   9 1788.0 0.517 1870.0, 17516.0 -0.26
B6.A-Chr7 f 10491.0 4856.0   10 1536.0 0.463 4651.0, 17265.0 -0.12
B6.A-Chr7 m 10229.0 3790.0   11 1143.0 0.371 6048.0, 15577.0 -0.3
B6.A-Chr8 f 3950.0 4180.0   12 1207.0 1.06 -1917.0, 10928.0 -1.7
B6.A-Chr8 m 8454.0 6027.0   8 2131.0 0.713 75.0, 18968.0 -0.8
B6.A-Chr9 f 13430.0 7278.0   10 2301.0 0.542 1376.0, 25637.0 0.59
B6.A-Chr9 m 11797.0 4297.0   9 1432.0 0.364 6211.0, 17847.0 0.13
B6.A-ChrX f 10085.0 5645.0   12 1630.0 0.56 -141.0, 20999.0 -0.22
B6.A-ChrX m 12678.0 7172.0   6 2928.0 0.566 -649.0, 18705.0 0.38
C57BL/6J f 11780.0 7089.0   55 956.0 0.602 -2313.0, 36653.0 0.19
C57BL/6J m 11546.0 5346.0   53 734.0 0.463 -229.0, 30771.0 0.06


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 1846.4444 1804.6095 5392.0485 0.0
A/J m 3574.1 1712.0029 6937.7553 210.4447
B6.A-Chr1 f 15616.5 2706.9143 20934.9061 10298.0939
B6.A-Chr1 m 6696.5 2210.1862 11038.9604 2354.0396
B6.A-Chr10 f 17014.3077 1501.5259 19964.4286 14064.1868
B6.A-Chr10 m 17242.75 1353.4571 19901.953 14583.547
B6.A-Chr11 f 6085.0 1446.9065 8927.8076 3242.1924
B6.A-Chr11 m 6587.6087 1128.8613 8805.5373 4369.68
B6.A-Chr12 f 18349.4 1397.8445 21095.8131 15602.9869
B6.A-Chr12 m 15450.8529 928.4639 17275.0512 13626.6547
B6.A-Chr14 f 12220.5556 1804.6095 15766.1596 8674.9515
B6.A-Chr14 m 11003.0 2421.1377 15759.927 6246.073
B6.A-Chr15 f 13455.8 1712.0029 16819.4553 10092.1447
B6.A-Chr15 m 15752.0 1501.5259 18702.1209 12801.8791
B6.A-Chr16 f 6159.6154 1501.5259 9109.7363 3209.4945
B6.A-Chr16 m 7898.6667 1804.6095 11444.2707 4353.0626
B6.A-Chr17 f 12010.0 3125.6754 18151.1663 5868.8337
B6.A-Chr17 m 16459.2222 1804.6095 20004.8263 12913.6182
B6.A-Chr18 f 10027.0 2421.1377 14783.927 5270.073
B6.A-Chr18 m 12851.4444 1804.6095 16397.0485 9305.8404
B6.A-Chr19 f 9604.5 1712.0029 12968.1553 6240.8447
B6.A-Chr19 m 14056.6 1712.0029 17420.2553 10692.9447
B6.A-Chr2 f 10663.4 1712.0029 14027.0553 7299.7447
B6.A-Chr2 m 12708.2 1712.0029 16071.8553 9344.5447
B6.A-Chr3 f 15391.875 1914.0774 19152.556 11631.194
B6.A-Chr3 m 13914.6429 1446.9065 16757.4505 11071.8352
B6.A-Chr4 f 8114.3 1712.0029 11477.9553 4750.6447
B6.A-Chr4 m 10150.1111 1804.6095 13695.7152 6604.5071
B6.A-Chr5 f 13158.7143 1446.9065 16001.5219 10315.9067
B6.A-Chr5 m 8252.7 1712.0029 11616.3553 4889.0447
B6.A-Chr6 f 11379.0 1712.0029 14742.6553 8015.3447
B6.A-Chr6 m 10372.1111 1804.6095 13917.7152 6826.5071
B6.A-Chr7 f 10490.6 1712.0029 13854.2553 7126.9447
B6.A-Chr7 m 10228.6364 1632.3307 13435.7559 7021.5168
B6.A-Chr8 f 3950.4167 1562.8377 7020.9998 879.8335
B6.A-Chr8 m 8454.25 1914.0774 12214.931 4693.569
B6.A-Chr9 f 13429.7 1712.0029 16793.3553 10066.0447
B6.A-Chr9 m 11797.2222 1804.6095 15342.8263 8251.6182
B6.A-ChrX f 10084.75 1562.8377 13155.3332 7014.1668
B6.A-ChrX m 12677.8333 2210.1862 17020.2937 8335.373
C57BL/6J f 11780.0182 730.0005 13214.2856 10345.7507
C57BL/6J m 11545.7736 743.6465 13006.8521 10084.6951


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 2710.2722 1243.7413 5153.9112 266.6333
B6.A-Chr1 both 11156.5 1747.3056 14589.5164 7723.4836
B6.A-Chr10 both 17128.5288 1010.7455 19114.3897 15142.6679
B6.A-Chr11 both 6336.3043 917.5874 8139.1329 4533.4758
B6.A-Chr12 both 16900.1265 839.0493 18548.6473 15251.6056
B6.A-Chr14 both 11611.7778 1509.8446 14578.2429 8645.3126
B6.A-Chr15 both 14603.9 1138.5884 16840.9399 12366.8601
B6.A-Chr16 both 7029.141 1173.7968 9335.3566 4722.9254
B6.A-Chr17 both 14234.6111 1804.6095 17780.2152 10689.0071
B6.A-Chr18 both 11439.2222 1509.8446 14405.6874 8472.7571
B6.A-Chr19 both 11830.55 1210.5689 14209.0135 9452.0865
B6.A-Chr2 both 11685.8 1210.5689 14064.2635 9307.3365
B6.A-Chr3 both 14653.2589 1199.7115 17010.3905 12296.1274
B6.A-Chr4 both 9132.2056 1243.7413 11575.8445 6688.5666
B6.A-Chr5 both 10705.7071 1120.769 12907.7365 8503.6778
B6.A-Chr6 both 10875.5556 1243.7413 13319.1945 8431.9166
B6.A-Chr7 both 10359.6182 1182.736 12683.397 8035.8393
B6.A-Chr8 both 6202.3333 1235.5317 8629.8425 3774.8242
B6.A-Chr9 both 12613.4611 1243.7413 15057.1001 10169.8222
B6.A-ChrX both 11381.2917 1353.4571 14040.4947 8722.0886
C57BL/6J both 11662.8959 521.0352 12686.5992 10639.1926




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA