Project measure / variable:   Paigen3   totHCC

ID, description, units MPD:2828   totHCC   hepatic cholesterol concentration (total per g liver)   [mg]  
high-fat diet study
Data set, strains Paigen3   obesity mutants   8 strains     sex: both     age: 15-19wks
Procedure lipid profile
Ontology mappings

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  STRAIN COMPARISON PLOT
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Paigen3 - hepatic cholesterol concentration (total per g liver)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains8 strains
Mean of the strain means42.3   mg 38.4   mg
Median of the strain means41.4   mg 35.8   mg
SD of the strain means± 6.94 ± 12.0
Coefficient of variation (CV)0.164 0.313
Min–max range of strain means32.3   –   51.6   mg 24.3   –   56.1   mg
Mean sample size per strain8.7   mice 9.5   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 1257.1231 1257.1231 12.5816 0.0006
strain 6 7025.8881 1170.9814 11.7195 < 0.0001
sex:strain 6 1633.6184 272.2697 2.725 0.0165
Residuals 113 11290.6484 99.9172


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6(AU)-Tubtub/J f 32.3 3.66   7 1.38 0.113 27.7, 37.1 -1.44
B6(AU)-Tubtub/J m 24.3 4.85   9 1.62 0.2 18.1, 31.5 -1.17
B6.BKS(D)-Leprdb/J m 56.1 9.18   10 2.9 0.164 39.3, 68.1 1.47
B6.Cg-Ay/J f 50.8 7.37   9 2.46 0.145 35.6, 60.9 1.23
B6.Cg-Ay/J m 31.4 8.39   10 2.65 0.268 15.4, 42.7 -0.58
B6.Cg-Lepob/J f 51.6 9.42   9 3.14 0.182 34.0, 64.2 1.34
B6.Cg-Lepob/J m 55.1 20.3   10 6.42 0.369 24.1, 86.3 1.39
BKS.Cg-Dock7m +/+ Leprdb/J f 41.4 9.69   9 3.23 0.234 28.9, 58.6 -0.13
BKS.Cg-Dock7m +/+ Leprdb/J m 40.2 10.2   10 3.22 0.253 28.7, 56.3 0.15
BKSChpLt.HRS-Cpefat/J f 37.2 6.53   9 2.18 0.176 27.9, 49.8 -0.74
BKSChpLt.HRS-Cpefat/J m 29.7 9.01   10 2.85 0.303 13.4, 41.7 -0.72
C57BL/6J f 42.3 11.5   10 3.64 0.272 24.6, 59.3 0.0
C57BL/6J m 41.3 8.67   10 2.74 0.21 28.0, 58.0 0.24
C57BLKS/J f 40.5 4.83   8 1.71 0.12 30.9, 45.2 -0.26
C57BLKS/J m 29.2 11.2   7 4.22 0.383 18.2, 48.9 -0.77


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J f 32.2857 3.7781 39.7708 24.8007
B6(AU)-Tubtub/J m 24.2556 3.332 30.8568 17.6544
B6.Cg-Ay/J f 50.7556 3.332 57.3568 44.1544
B6.Cg-Ay/J m 31.37 3.161 37.6324 25.1076
B6.Cg-Lepob/J f 51.6444 3.332 58.2456 45.0432
B6.Cg-Lepob/J m 55.06 3.161 61.3224 48.7976
BKS.Cg-Dock7m +/+ Leprdb/J f 41.4333 3.332 48.0345 34.8321
BKS.Cg-Dock7m +/+ Leprdb/J m 40.23 3.161 46.4924 33.9676
BKSChpLt.HRS-Cpefat/J f 37.1667 3.332 43.7679 30.5655
BKSChpLt.HRS-Cpefat/J m 29.7 3.161 35.9624 23.4376
C57BL/6J f 42.27 3.161 48.5324 36.0076
C57BL/6J m 41.29 3.161 47.5524 35.0276
C57BLKS/J f 40.45 3.5341 47.4516 33.4484
C57BLKS/J m 29.1571 3.7781 36.6422 21.6721


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J both 28.2706 2.5187 33.2607 23.2806
B6.Cg-Ay/J both 41.0628 2.2964 45.6123 36.5132
B6.Cg-Lepob/J both 53.3522 2.2964 57.9018 48.8027
BKS.Cg-Dock7m +/+ Leprdb/J both 40.8317 2.2964 45.3812 36.2821
BKSChpLt.HRS-Cpefat/J both 33.4333 2.2964 37.9829 28.8838
C57BL/6J both 41.78 2.2351 46.2082 37.3518
C57BLKS/J both 34.8036 2.5867 39.9282 29.6789




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA