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Project measure / variable:   Paigen3   ALT

ID, description, units MPD:2824   ALT   alanine transaminase (plasma ALT)   [IU/L]  
high-fat diet study
Data set, strains Paigen3   obesity mutants   8 strains     sex: both     age: 15-19wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Paigen3 - alanine transaminase (plasma ALT)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains8 strains
Mean of the strain means213   IU/L 288   IU/L
Median of the strain means151   IU/L 137   IU/L
SD of the strain means± 172 ± 298
Coefficient of variation (CV)0.808 1.03
Min–max range of strain means54.9   –   486   IU/L 91.5   –   936   IU/L
Mean sample size per strain17.4   mice 14.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 6212.5969 6212.5969 0.8497 0.3577
strain 6 4035580.3676 672596.7279 91.9897 < 0.0001
sex:strain 6 334615.5201 55769.2534 7.6275 < 0.0001
Residuals 219 1601251.318 7311.6499


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6(AU)-Tubtub/J f 103.0 20.9   21 4.55 0.203 62.0, 149.0 -0.64
B6(AU)-Tubtub/J m 112.0 36.3   20 8.11 0.324 62.0, 191.0 -0.59
B6.BKS(D)-Leprdb/J m 936.0 444.0   4 222.0 0.475 309.0, 1340.0 2.17
B6.Cg-Ay/J f 54.9 18.4   18 4.33 0.335 27.0, 93.0 -0.92
B6.Cg-Ay/J m 91.5 31.5   19 7.23 0.345 44.0, 163.0 -0.66
B6.Cg-Lepob/J f 486.0 138.0   10 43.6 0.283 258.0, 706.0 1.58
B6.Cg-Lepob/J m 525.0 148.0   12 42.7 0.282 231.0, 776.0 0.79
BKS.Cg-Dock7m +/+ Leprdb/J f 407.0 110.0   17 26.7 0.27 168.0, 602.0 1.12
BKS.Cg-Dock7m +/+ Leprdb/J m 252.0 83.7   15 21.6 0.332 86.0, 350.0 -0.12
BKSChpLt.HRS-Cpefat/J f 235.0 122.0   14 32.6 0.52 60.0, 420.0 0.13
BKSChpLt.HRS-Cpefat/J m 117.0 61.3   16 15.3 0.525 35.0, 236.0 -0.58
C57BL/6J f 56.5 13.9   15 3.59 0.246 36.0, 84.0 -0.91
C57BL/6J m 127.0 47.1   14 12.6 0.37 61.0, 214.0 -0.54
C57BLKS/J f 151.0 126.0   27 24.3 0.833 24.0, 394.0 -0.36
C57BLKS/J m 147.0 102.0   15 26.3 0.691 41.0, 362.0 -0.47


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J f 102.7619 18.6594 139.5369 65.9869
B6(AU)-Tubtub/J m 111.85 19.1202 149.5332 74.1668
B6.Cg-Ay/J f 54.8889 20.1545 94.6104 15.1673
B6.Cg-Ay/J m 91.4737 19.6169 130.1358 52.8116
B6.Cg-Lepob/J f 486.5 27.0401 539.7921 433.2079
B6.Cg-Lepob/J m 524.9167 24.6841 573.5654 476.2679
BKS.Cg-Dock7m +/+ Leprdb/J f 406.9412 20.7388 447.8143 366.068
BKS.Cg-Dock7m +/+ Leprdb/J m 252.3333 22.0781 295.8461 208.8206
BKSChpLt.HRS-Cpefat/J f 234.6429 22.853 279.6829 189.6029
BKSChpLt.HRS-Cpefat/J m 116.625 21.377 158.7561 74.4939
C57BL/6J f 56.4667 22.0781 99.9794 12.9539
C57BL/6J m 127.1429 22.853 172.1829 82.1029
C57BLKS/J f 151.4815 16.4561 183.914 119.049
C57BLKS/J m 147.4 22.0781 190.9128 103.8872


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J both 107.306 13.3581 133.6329 80.9791
B6.Cg-Ay/J both 73.1813 14.0626 100.8966 45.4659
B6.Cg-Lepob/J both 505.7083 18.3062 541.7872 469.6294
BKS.Cg-Dock7m +/+ Leprdb/J both 329.6373 15.1455 359.4868 299.7877
BKSChpLt.HRS-Cpefat/J both 175.6339 15.6464 206.4707 144.7971
C57BL/6J both 91.8048 15.8879 123.1176 60.492
C57BLKS/J both 149.4407 13.7681 176.5757 122.3058




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA