Project measure / variable:   Paigen3   smallLC

ID, description, units MPD:2812   smallLC   gallbladder, small liquid crystals (score: 0-4)   [score]  
high-fat diet study
Data set, strains Paigen3   obesity mutants   7 strains     sex: both     age: 15-19wks
Procedure histopathology
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  STRAIN COMPARISON PLOT
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Paigen3 - gallbladder, small liquid crystals (score: 0-4)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains7 strains
Mean of the strain means1.41   score 1.02   score
Median of the strain means1.08   score 1.17   score
SD of the strain means± 0.573 ± 0.310
Coefficient of variation (CV)0.406 0.304
Min–max range of strain means0.938   –   2.50   score 0.500   –   1.33   score
Mean sample size per strain7.7   mice 8.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 5.9607 5.9607 14.0142 0.0003
strain 6 16.0512 2.6752 6.2896 < 0.0001
sex:strain 6 6.5823 1.097 2.5793 0.0231
Residuals 98 41.6826 0.4253


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6(AU)-Tubtub/J f 1.5 0.791   9 0.264 0.527 0.5, 3.0 0.16
B6(AU)-Tubtub/J m 1.33 0.707   9 0.236 0.53 1.0, 3.0 0.99
B6.Cg-Ay/J f 1.8 0.837   5 0.374 0.465 1.0, 3.0 0.68
B6.Cg-Ay/J m 1.0 0.408   10 0.129 0.408 0.5, 2.0 -0.07
B6.Cg-Lepob/J f 1.0 0.0   7 0.0 0.0 1.0, 1.0 -0.72
B6.Cg-Lepob/J m 1.25 0.463   8 0.164 0.37 1.0, 2.0 0.74
BKS.Cg-Dock7m +/+ Leprdb/J f 1.06 0.768   9 0.256 0.728 0.5, 3.0 -0.61
BKS.Cg-Dock7m +/+ Leprdb/J m 0.5 0.236   10 0.0745 0.471 -1.68
BKSChpLt.HRS-Cpefat/J f 0.938 0.563   8 0.199 0.601 -0.83
BKSChpLt.HRS-Cpefat/J m 0.7 0.823   10 0.26 1.18 -1.04
C57BL/6J f 2.5 1.08   10 0.342 0.432 1.0, 4.0 1.9
C57BL/6J m 1.17 0.408   6 0.167 0.35 1.0, 2.0 0.48
C57BLKS/J f 1.08 0.492   6 0.201 0.454 0.5, 2.0 -0.58
C57BLKS/J m 1.2 0.447   5 0.2 0.373 1.0, 2.0 0.58


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J f 1.5 0.2174 1.9314 1.0686
B6(AU)-Tubtub/J m 1.3333 0.2174 1.7647 0.9019
B6.Cg-Ay/J f 1.8 0.2917 2.3788 1.2212
B6.Cg-Ay/J m 1.0 0.2062 1.4093 0.5907
B6.Cg-Lepob/J f 1.0 0.2465 1.4892 0.5108
B6.Cg-Lepob/J m 1.25 0.2306 1.7076 0.7924
BKS.Cg-Dock7m +/+ Leprdb/J f 1.0556 0.2174 1.487 0.6241
BKS.Cg-Dock7m +/+ Leprdb/J m 0.5 0.2062 0.9093 0.0907
BKSChpLt.HRS-Cpefat/J f 0.9375 0.2306 1.3951 0.4799
BKSChpLt.HRS-Cpefat/J m 0.7 0.2062 1.1093 0.2907
C57BL/6J f 2.5 0.2062 2.9093 2.0907
C57BL/6J m 1.1667 0.2662 1.695 0.6383
C57BLKS/J f 1.0833 0.2662 1.6117 0.555
C57BLKS/J m 1.2 0.2917 1.7788 0.6212


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J both 1.4167 0.1537 1.7217 1.1116
B6.Cg-Ay/J both 1.4 0.1786 1.7544 1.0456
B6.Cg-Lepob/J both 1.125 0.1688 1.4599 0.7901
BKS.Cg-Dock7m +/+ Leprdb/J both 0.7778 0.1498 1.0751 0.4805
BKSChpLt.HRS-Cpefat/J both 0.8188 0.1547 1.1257 0.5118
C57BL/6J both 1.8333 0.1684 2.1675 1.4992
C57BLKS/J both 1.1417 0.1975 1.5335 0.7498




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA