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Project measure / variable:   Paigen3   finalbw

ID, description, units MPD:2806   finalbw   body weight   [g]  after 8wks on diet  
high-fat diet study
Data set, strains Paigen3   obesity mutants   8 strains     sex: both     age: 7-11wks
Procedure body weight
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  STRAIN COMPARISON PLOT
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Paigen3 - body weight after 8wks on diet



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains8 strains
Mean of the strain means31.6   g 37.4   g
Median of the strain means26.1   g 35.0   g
SD of the strain means± 13.2 ± 12.8
Coefficient of variation (CV)0.417 0.343
Min–max range of strain means20.6   –   57.3   g 24.7   –   59.1   g
Mean sample size per strain20.6   mice 20.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 2044.8013 2044.8013 135.4381 < 0.0001
strain 6 38328.6523 6388.1087 423.1186 < 0.0001
sex:strain 6 287.3452 47.8909 3.1721 0.005
Residuals 274 4136.7644 15.0977


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6(AU)-Tubtub/J f 31.6 3.21   24 0.655 0.102 26.6, 39.1 0.0
B6(AU)-Tubtub/J m 39.8 4.66   24 0.95 0.117 28.0, 46.2 0.19
B6.BKS(D)-Leprdb/J m 48.8 4.67   16 1.17 0.0957 37.1, 56.5 0.89
B6.Cg-Ay/J f 26.1 3.33   23 0.693 0.128 19.4, 32.4 -0.42
B6.Cg-Ay/J m 30.1 2.71   34 0.466 0.0902 25.2, 35.5 -0.57
B6.Cg-Lepob/J f 57.3 4.19   17 1.02 0.0732 48.0, 63.7 1.95
B6.Cg-Lepob/J m 59.1 5.85   21 1.28 0.0989 42.8, 66.9 1.7
BKS.Cg-Dock7m +/+ Leprdb/J f 39.9 6.76   18 1.59 0.169 24.9, 47.0 0.63
BKS.Cg-Dock7m +/+ Leprdb/J m 44.9 6.57   15 1.7 0.146 31.0, 55.0 0.59
BKSChpLt.HRS-Cpefat/J f 24.1 4.21   16 1.05 0.175 18.2, 35.0 -0.57
BKSChpLt.HRS-Cpefat/J m 26.4 3.39   18 0.798 0.128 19.6, 33.2 -0.86
C57BL/6J f 21.5 1.22   19 0.28 0.0568 19.6, 24.7 -0.77
C57BL/6J m 25.2 1.47   15 0.38 0.0584 23.2, 28.7 -0.95
C57BLKS/J f 20.6 1.0   27 0.193 0.0487 18.7, 22.1 -0.83
C57BLKS/J m 24.7 1.26   17 0.306 0.051 22.2, 26.6 -0.99


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J f 31.5542 0.7931 33.1156 29.9927
B6(AU)-Tubtub/J m 39.825 0.7931 41.3864 38.2636
B6.Cg-Ay/J f 26.0652 0.8102 27.6602 24.4702
B6.Cg-Ay/J m 30.1 0.6664 31.4119 28.7881
B6.Cg-Lepob/J f 57.3176 0.9424 59.1729 55.4624
B6.Cg-Lepob/J m 59.1048 0.8479 60.774 57.4355
BKS.Cg-Dock7m +/+ Leprdb/J f 39.9222 0.9158 41.7252 38.1192
BKS.Cg-Dock7m +/+ Leprdb/J m 44.8533 1.0033 46.8284 42.8783
BKSChpLt.HRS-Cpefat/J f 24.0563 0.9714 25.9686 22.1439
BKSChpLt.HRS-Cpefat/J m 26.4389 0.9158 28.2419 24.6359
C57BL/6J f 21.5 0.8914 23.2549 19.7451
C57BL/6J m 25.1867 1.0033 27.1617 23.2116
C57BLKS/J f 20.6222 0.7478 22.0943 19.1501
C57BLKS/J m 24.7353 0.9424 26.5905 22.88


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J both 35.6896 0.5608 36.7937 34.5855
B6.Cg-Ay/J both 28.0826 0.5245 29.1152 27.05
B6.Cg-Lepob/J both 58.2112 0.6338 59.459 56.9634
BKS.Cg-Dock7m +/+ Leprdb/J both 42.3878 0.6792 43.7249 41.0507
BKSChpLt.HRS-Cpefat/J both 25.2476 0.6675 26.5617 23.9334
C57BL/6J both 23.3433 0.671 24.6644 22.0223
C57BLKS/J both 22.6788 0.6015 23.8629 21.4946




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA