Project measure / variable:   Svenson3   AST

ID, description, units MPD:27367   AST   aspartate transaminase (plasma AST)   [mg/dL]  
Data set, strains Svenson3   B6.PWD consomic w/par   21 strains     sex: both     age: 8wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Svenson3 - aspartate transaminase (plasma AST)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested20 strains21 strains
Mean of the strain means77.6   mg/dL 72.8   mg/dL
Median of the strain means74.1   mg/dL 65.0   mg/dL
SD of the strain means± 18.9 ± 23.5
Coefficient of variation (CV)0.243 0.323
Min–max range of strain means46.0   –   136   mg/dL 49.5   –   154   mg/dL
Mean sample size per strain6.6   mice 7.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 4014.7626 4014.7626 7.0774 0.0084
strain 19 54956.3427 2892.4391 5.0989 < 0.0001
sex:strain 19 10093.5019 531.2369 0.9365 0.5383
Residuals 232 131605.7127 567.266


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6.PWD-Chr1 f 89.2 27.8   8 9.84 0.312 60.0, 131.0 0.61
B6.PWD-Chr1 m 88.3 32.6   7 12.3 0.369 58.0, 135.0 0.66
B6.PWD-Chr11.1 f 136.0 0.707   2   0.5 0.00522 135.0, 136.0 3.09
B6.PWD-Chr11.1 m 154.0 49.5   2   35.0 0.321 119.0, 189.0 3.45
B6.PWD-Chr11.2 f 94.8 36.1   4 18.1 0.381 59.0, 142.0 0.91
B6.PWD-Chr11.2 m 99.5 13.4   2   9.5 0.135 90.0, 109.0 1.13
B6.PWD-Chr11.3 f 75.8 25.1   8 8.89 0.332 56.0, 134.0 -0.1
B6.PWD-Chr11.3 m 72.5 23.1   8 8.17 0.319 40.0, 121.0 -0.01
B6.PWD-Chr12 f 64.8 6.65   6 2.71 0.103 57.0, 74.0 -0.68
B6.PWD-Chr12 m 64.6 20.4   7 7.7 0.316 50.0, 110.0 -0.35
B6.PWD-Chr13 f 71.9 16.9   8 5.98 0.235 48.0, 94.0 -0.3
B6.PWD-Chr13 m 65.0 12.6   8 4.45 0.194 42.0, 81.0 -0.33
B6.PWD-Chr14 f 82.3 29.7   7 11.2 0.361 45.0, 143.0 0.25
B6.PWD-Chr14 m 60.6 4.87   8 1.72 0.0803 55.0, 66.0 -0.52
B6.PWD-Chr15 f 93.0 38.0   8 13.4 0.408 56.0, 180.0 0.81
B6.PWD-Chr15 m 64.0 7.48   8 2.65 0.117 55.0, 77.0 -0.37
B6.PWD-Chr16 f 72.4 33.1   7 12.5 0.458 49.0, 131.0 -0.28
B6.PWD-Chr16 m 52.2 4.3   8 1.52 0.0823 45.0, 57.0 -0.88
B6.PWD-Chr17 f 68.8 28.9   4 14.4 0.42 53.0, 112.0 -0.47
B6.PWD-Chr17 m 51.3 7.37   3 4.26 0.144 43.0, 57.0 -0.91
B6.PWD-Chr18 f 60.6 15.3   5 6.82 0.252 48.0, 84.0 -0.9
B6.PWD-Chr18 m 67.8 21.6   9 7.19 0.318 47.0, 118.0 -0.21
B6.PWD-Chr19 f 91.4 23.4   8 8.26 0.256 61.0, 125.0 0.73
B6.PWD-Chr19 m 67.1 20.9   8 7.38 0.311 53.0, 117.0 -0.24
B6.PWD-Chr2 f 76.4 24.3   7 9.17 0.317 52.0, 123.0 -0.06
B6.PWD-Chr2 m 91.8 37.8   10 12.0 0.412 62.0, 191.0 0.81
B6.PWD-Chr3 f 87.7 37.0   7 14.0 0.422 51.0, 167.0 0.53
B6.PWD-Chr3 m 97.0 27.5   8 9.71 0.283 66.0, 149.0 1.03
B6.PWD-Chr5 f 46.0 2.83   2   2.0 0.0615 44.0, 48.0 -1.67
B6.PWD-Chr5 m 49.5 5.78   8 2.04 0.117 40.0, 60.0 -0.99
B6.PWD-Chr6 f 83.0 24.3   9 8.1 0.293 56.0, 120.0 0.28
B6.PWD-Chr6 m 69.9 27.8   8 9.82 0.398 49.0, 134.0 -0.12
B6.PWD-Chr9 f 66.9 14.5   7 5.47 0.217 58.0, 99.0 -0.57
B6.PWD-Chr9 m 64.0 15.6   8 5.53 0.244 49.0, 97.0 -0.37
B6.PWD-ChrX.1 f 59.4 7.23   8 2.56 0.122 49.0, 69.0 -0.96
B6.PWD-ChrX.1 m 56.9 14.8   8 5.24 0.261 47.0, 90.0 -0.68
B6.PWD-ChrX.2 m 74.2 18.0   4 8.99 0.242 53.0, 97.0 0.06
B6.PWD-ChrY f 61.0 14.5   7 5.49 0.238 44.0, 82.0 -0.88
B6.PWD-ChrY m 55.6 10.7   7 4.05 0.193 47.0, 75.0 -0.73
B6.PWD-mt f 71.1 15.8   7 5.97 0.222 55.0, 100.0 -0.35
B6.PWD-mt m 63.1 44.6   8 15.8 0.706 42.0, 173.0 -0.41


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6.PWD-Chr1 f 89.25 8.4207 105.8408 72.6592
B6.PWD-Chr1 m 88.2857 9.0021 106.0221 70.5494
B6.PWD-Chr11.1 f 135.5 16.8414 168.6816 102.3184
B6.PWD-Chr11.1 m 154.0 16.8414 187.1816 120.8184
B6.PWD-Chr11.2 f 94.75 11.9087 118.213 71.287
B6.PWD-Chr11.2 m 99.5 16.8414 132.6816 66.3184
B6.PWD-Chr11.3 f 75.75 8.4207 92.3408 59.1592
B6.PWD-Chr11.3 m 72.5 8.4207 89.0908 55.9092
B6.PWD-Chr12 f 64.8333 9.7234 83.9908 45.6759
B6.PWD-Chr12 m 64.5714 9.0021 82.3078 46.8351
B6.PWD-Chr13 f 71.875 8.4207 88.4658 55.2842
B6.PWD-Chr13 m 65.0 8.4207 81.5908 48.4092
B6.PWD-Chr14 f 82.2857 9.0021 100.0221 64.5494
B6.PWD-Chr14 m 60.625 8.4207 77.2158 44.0342
B6.PWD-Chr15 f 93.0 8.4207 109.5908 76.4092
B6.PWD-Chr15 m 64.0 8.4207 80.5908 47.4092
B6.PWD-Chr16 f 72.4286 9.0021 90.1649 54.6922
B6.PWD-Chr16 m 52.25 8.4207 68.8408 35.6592
B6.PWD-Chr17 f 68.75 11.9087 92.213 45.287
B6.PWD-Chr17 m 51.3333 13.751 78.426 24.2406
B6.PWD-Chr18 f 60.6 10.6514 81.5859 39.6141
B6.PWD-Chr18 m 67.7778 7.9391 83.4198 52.1358
B6.PWD-Chr19 f 91.375 8.4207 107.9658 74.7842
B6.PWD-Chr19 m 67.125 8.4207 83.7158 50.5342
B6.PWD-Chr2 f 76.4286 9.0021 94.1649 58.6922
B6.PWD-Chr2 m 91.8 7.5317 106.6393 76.9607
B6.PWD-Chr3 f 87.7143 9.0021 105.4506 69.9779
B6.PWD-Chr3 m 97.0 8.4207 113.5908 80.4092
B6.PWD-Chr5 f 46.0 16.8414 79.1816 12.8184
B6.PWD-Chr5 m 49.5 8.4207 66.0908 32.9092
B6.PWD-Chr6 f 83.0 7.9391 98.642 67.358
B6.PWD-Chr6 m 69.875 8.4207 86.4658 53.2842
B6.PWD-Chr9 f 66.8571 9.0021 84.5935 49.1208
B6.PWD-Chr9 m 64.0 8.4207 80.5908 47.4092
B6.PWD-ChrX.1 f 59.375 8.4207 75.9658 42.7842
B6.PWD-ChrX.1 m 56.875 8.4207 73.4658 40.2842
B6.PWD-ChrY f 61.0 9.0021 78.7363 43.2637
B6.PWD-ChrY m 55.5714 9.0021 73.3078 37.8351
B6.PWD-mt f 71.1429 9.0021 88.8792 53.4065
B6.PWD-mt m 63.125 8.4207 79.7158 46.5342


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6.PWD-Chr1 both 88.7679 6.1633 100.9111 76.6246
B6.PWD-Chr11.1 both 144.75 11.9087 168.213 121.287
B6.PWD-Chr11.2 both 97.125 10.3132 117.4445 76.8055
B6.PWD-Chr11.3 both 74.125 5.9543 85.8565 62.3935
B6.PWD-Chr12 both 64.7024 6.6254 77.756 51.6488
B6.PWD-Chr13 both 68.4375 5.9543 80.169 56.706
B6.PWD-Chr14 both 71.4554 6.1633 83.5986 59.3121
B6.PWD-Chr15 both 78.5 5.9543 90.2315 66.7685
B6.PWD-Chr16 both 62.3393 6.1633 74.4825 50.196
B6.PWD-Chr17 both 60.0417 9.0954 77.9618 42.1215
B6.PWD-Chr18 both 64.1889 6.6423 77.2759 51.1019
B6.PWD-Chr19 both 79.25 5.9543 90.9815 67.5185
B6.PWD-Chr2 both 84.1143 5.8687 95.677 72.5516
B6.PWD-Chr3 both 92.3571 6.1633 104.5004 80.2139
B6.PWD-Chr5 both 47.75 9.4146 66.2991 29.2009
B6.PWD-Chr6 both 76.4375 5.7866 87.8385 65.0365
B6.PWD-Chr9 both 65.4286 6.1633 77.5718 53.2853
B6.PWD-ChrX.1 both 58.125 5.9543 69.8565 46.3935
B6.PWD-ChrY both 58.2857 6.3655 70.8272 45.7442
B6.PWD-mt both 67.1339 6.1633 79.2772 54.9907




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA