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Project measure / variable:   Jaxpheno3   ALT8

ID, description, units MPD:22815   ALT8   alanine transaminase (plasma ALT)   [IU/L]  at age 8wks  
Data set, strains Jaxpheno3   inbred   11 strains     sex: both     age: 8wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Jaxpheno3 - alanine transaminase (plasma ALT) at age 8wks



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested11 strains11 strains
Mean of the strain means50.7   IU/L 60.2   IU/L
Median of the strain means45.0   IU/L 59.8   IU/L
SD of the strain means± 13.5 ± 14.9
Coefficient of variation (CV)0.267 0.247
Min–max range of strain means36.2   –   72.8   IU/L 40.4   –   90.9   IU/L
Mean sample size per strain15.8   mice 17.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 7525.8328 7525.8328 8.0284 0.0049
strain 10 57100.3412 5710.0341 6.0914 < 0.0001
sex:strain 10 13697.336 1369.7336 1.4612 0.1519
Residuals 378 354336.1874 937.3973


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6.129P2-Apoetm1Unc/J f 41.7 5.48   10 1.73 0.131 33.0, 51.0 -0.67
B6.129P2-Apoetm1Unc/J m 40.4 13.0   10 4.12 0.323 23.0, 67.0 -1.33
B6D2F1/J f 70.2 44.0   10 13.9 0.627 29.0, 152.0 1.44
B6D2F1/J m 65.8 38.5   10 12.2 0.585 31.0, 163.0 0.38
BALB/cByJ f 72.8 31.7   20 7.08 0.435 34.0, 147.0 1.63
BALB/cByJ m 90.9 42.5   20 9.5 0.467 31.0, 179.0 2.06
BALB/cJ f 68.0 26.1   20 5.83 0.384 38.0, 136.0 1.28
BALB/cJ m 59.8 38.5   22 8.22 0.645 23.0, 168.0 -0.03
C3H/HeJ f 47.3 6.55   10 2.07 0.138 40.0, 60.0 -0.25
C3H/HeJ m 45.7 7.65   10 2.42 0.167 35.0, 59.0 -0.97
C57BL/6J f 43.1 14.6   30 2.67 0.34 30.0, 110.0 -0.56
C57BL/6J m 57.3 39.9   54 5.43 0.696 22.0, 224.0 -0.19
CBA/J f 38.2 10.5   21 2.29 0.275 28.0, 66.0 -0.92
CBA/J m 41.4 8.99   30 1.64 0.217 31.0, 65.0 -1.26
DBA/2J f 54.7 24.6   21 5.37 0.45 32.0, 133.0 0.29
DBA/2J m 58.4 56.1   20 12.5 0.961 25.0, 282.0 -0.12
FVB/NJ f 45.0 6.9   10 2.18 0.153 32.0, 56.0 -0.42
FVB/NJ m 76.1 23.5   12 6.79 0.309 43.0, 119.0 1.07
NOD.CB17-Prkdcscid/J f 40.7 7.9   10 2.5 0.194 34.0, 55.0 -0.74
NOD.CB17-Prkdcscid/J m 64.0 21.6   10 6.83 0.337 41.0, 97.0 0.26
NOD/ShiLtJ f 36.2 9.38   20 2.1 0.259 23.0, 63.0 -1.07
NOD/ShiLtJ m 62.4 47.8   20 10.7 0.766 32.0, 229.0 0.15


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6.129P2-Apoetm1Unc/J f 41.7 9.6819 60.7372 22.6628
B6.129P2-Apoetm1Unc/J m 40.4 9.6819 59.4372 21.3628
B6D2F1/J f 70.2 9.6819 89.2372 51.1628
B6D2F1/J m 65.8 9.6819 84.8372 46.7628
BALB/cByJ f 72.8 6.8462 86.2613 59.3387
BALB/cByJ m 90.9 6.8462 104.3613 77.4387
BALB/cJ f 67.95 6.8462 81.4113 54.4887
BALB/cJ m 59.7727 6.5276 72.6076 46.9379
C3H/HeJ f 47.3 9.6819 66.3372 28.2628
C3H/HeJ m 45.7 9.6819 64.7372 26.6628
C57BL/6J f 43.0667 5.5899 54.0578 32.0755
C57BL/6J m 57.3333 4.1664 65.5256 49.141
CBA/J f 38.1905 6.6812 51.3274 25.0536
CBA/J m 41.3667 5.5899 52.3578 30.3755
DBA/2J f 54.7143 6.6812 67.8512 41.5774
DBA/2J m 58.4 6.8462 71.8613 44.9387
FVB/NJ f 45.0 9.6819 64.0372 25.9628
FVB/NJ m 76.0833 8.8384 93.4618 58.7048
NOD.CB17-Prkdcscid/J f 40.7 9.6819 59.7372 21.6628
NOD.CB17-Prkdcscid/J m 64.0 9.6819 83.0372 44.9628
NOD/ShiLtJ f 36.25 6.8462 49.7113 22.7887
NOD/ShiLtJ m 62.35 6.8462 75.8113 48.8887


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6.129P2-Apoetm1Unc/J both 41.05 6.8462 54.5113 27.5887
B6D2F1/J both 68.0 6.8462 81.4613 54.5387
BALB/cByJ both 81.85 4.841 91.3686 72.3314
BALB/cJ both 63.8614 4.7297 73.1611 54.5616
C3H/HeJ both 46.5 6.8462 59.9613 33.0387
C57BL/6J both 50.2 3.4859 57.0542 43.3458
CBA/J both 39.7786 4.3556 48.3428 31.2144
DBA/2J both 56.5571 4.783 65.9617 47.1525
FVB/NJ both 60.5417 6.5547 73.4299 47.6534
NOD.CB17-Prkdcscid/J both 52.35 6.8462 65.8113 38.8887
NOD/ShiLtJ both 49.3 4.841 58.8186 39.7814




  GWAS USING LINEAR MIXED MODELS