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Project measure / variable:   Lake1   CHOL

ID, description, units MPD:19925   CHOL   total cholesterol (plasma CHOL)   [mg/dL]  
Data set, strains Lake1   B6.A consomic w/par   23 strains     sex: both     age: 8wks
Procedure lipid profile
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  STRAIN COMPARISON PLOT
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Lake1 - total cholesterol (plasma CHOL)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested23 strains23 strains
Mean of the strain means77.4   mg/dL 101   mg/dL
Median of the strain means77.4   mg/dL 102   mg/dL
SD of the strain means± 6.27 ± 10.4
Coefficient of variation (CV)0.0810 0.103
Min–max range of strain means62.4   –   89.9   mg/dL 75.1   –   117   mg/dL
Mean sample size per strain8.0   mice 8.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 49618.8945 49618.8945 802.8673 < 0.0001
strain 22 21262.4035 966.4729 15.6382 < 0.0001
sex:strain 22 4935.2387 224.329 3.6298 < 0.0001
Residuals 327 20209.2917 61.8021


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 69.9 7.34   8 2.59 0.105 59.0, 81.0 -1.2
A/J m 75.1 5.77   8 2.04 0.0768 69.0, 84.0 -2.48
B6.A-Chr1 f 78.1 11.7   8 4.15 0.15 55.0, 94.0 0.11
B6.A-Chr1 m 111.0 4.55   8 1.61 0.0409 108.0, 121.0 0.98
B6.A-Chr10 f 77.4 6.21   8 2.2 0.0802 64.0, 83.0 0.0
B6.A-Chr10 m 92.8 9.13   8 3.23 0.0984 75.0, 103.0 -0.77
B6.A-Chr11 f 73.6 5.1   8 1.8 0.0692 67.0, 83.0 -0.61
B6.A-Chr11 m 95.2 3.58   8 1.26 0.0375 90.0, 103.0 -0.54
B6.A-Chr12 f 75.5 8.21   8 2.9 0.109 62.0, 85.0 -0.3
B6.A-Chr12 m 101.0 17.8   8 6.28 0.176 78.0, 129.0 0.02
B6.A-Chr13 f 86.6 4.03   8 1.43 0.0466 80.0, 93.0 1.47
B6.A-Chr13 m 108.0 10.3   8 3.64 0.0959 93.0, 123.0 0.69
B6.A-Chr14 f 77.5 6.72   8 2.38 0.0867 68.0, 90.0 0.02
B6.A-Chr14 m 110.0 5.95   8 2.1 0.0543 104.0, 122.0 0.89
B6.A-Chr15 f 75.3 6.42   9 2.14 0.0853 66.0, 85.0 -0.34
B6.A-Chr15 m 109.0 6.1   8 2.16 0.0561 102.0, 117.0 0.79
B6.A-Chr16 f 79.8 6.09   8 2.15 0.0763 69.0, 87.0 0.38
B6.A-Chr16 m 117.0 11.1   8 3.91 0.0948 105.0, 136.0 1.56
B6.A-Chr17 f 73.6 9.59   8 3.39 0.13 61.0, 89.0 -0.61
B6.A-Chr17 m 102.0 4.07   8 1.44 0.0399 95.0, 109.0 0.12
B6.A-Chr18 f 73.4 10.1   8 3.57 0.138 58.0, 88.0 -0.64
B6.A-Chr18 m 92.9 8.25   8 2.92 0.0889 76.0, 103.0 -0.76
B6.A-Chr19 f 81.0 5.83   8 2.06 0.072 74.0, 93.0 0.57
B6.A-Chr19 m 111.0 10.2   8 3.61 0.092 96.0, 124.0 0.98
B6.A-Chr2 f 80.0 7.5   8 2.65 0.0938 68.0, 91.0 0.41
B6.A-Chr2 m 102.0 6.21   8 2.2 0.0607 92.0, 109.0 0.12
B6.A-Chr3 f 74.1 9.01   8 3.19 0.122 60.0, 87.0 -0.53
B6.A-Chr3 m 98.0 6.76   8 2.39 0.069 87.0, 110.0 -0.27
B6.A-Chr4 f 69.1 3.0   8 1.06 0.0434 65.0, 74.0 -1.32
B6.A-Chr4 m 83.4 3.11   8 1.1 0.0373 79.0, 87.0 -1.68
B6.A-Chr5 f 62.4 5.88   8 2.08 0.0942 53.0, 69.0 -2.39
B6.A-Chr5 m 88.4 5.83   8 2.06 0.066 82.0, 97.0 -1.2
B6.A-Chr6 f 73.9 4.36   8 1.54 0.059 70.0, 80.0 -0.56
B6.A-Chr6 m 99.5 5.18   8 1.83 0.0521 91.0, 107.0 -0.13
B6.A-Chr7 f 83.9 10.5   8 3.7 0.125 74.0, 107.0 1.04
B6.A-Chr7 m 105.0 5.37   8 1.9 0.0513 98.0, 114.0 0.4
B6.A-Chr8 f 74.2 7.76   8 2.74 0.105 62.0, 86.0 -0.51
B6.A-Chr8 m 88.7 5.28   12 1.52 0.0595 76.0, 96.0 -1.17
B6.A-Chr9 f 83.0 6.72   8 2.38 0.0809 76.0, 96.0 0.89
B6.A-Chr9 m 110.0 5.48   8 1.94 0.0496 102.0, 118.0 0.89
B6.A-ChrX f 84.1 8.32   8 2.94 0.0989 73.0, 99.0 1.07
B6.A-ChrX m 99.5 8.4   8 2.97 0.0844 85.0, 108.0 -0.13
B6.A-ChrY f 84.0 6.44   8 2.28 0.0766 72.0, 91.0 1.05
B6.A-ChrY m 108.0 12.7   8 4.49 0.118 90.0, 130.0 0.69
C57BL/6J f 89.9 13.5   8 4.77 0.15 78.0, 120.0 1.99
C57BL/6J m 111.0 6.11   8 2.16 0.0552 104.0, 123.0 0.98


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 69.875 2.7794 75.3428 64.4072
A/J m 75.125 2.7794 80.5928 69.6572
B6.A-Chr1 f 78.125 2.7794 83.5928 72.6572
B6.A-Chr1 m 111.125 2.7794 116.5928 105.6572
B6.A-Chr10 f 77.375 2.7794 82.8428 71.9072
B6.A-Chr10 m 92.75 2.7794 98.2178 87.2822
B6.A-Chr11 f 73.625 2.7794 79.0928 68.1572
B6.A-Chr11 m 95.25 2.7794 100.7178 89.7822
B6.A-Chr12 f 75.5 2.7794 80.9678 70.0322
B6.A-Chr12 m 100.625 2.7794 106.0928 95.1572
B6.A-Chr13 f 86.625 2.7794 92.0928 81.1572
B6.A-Chr13 m 107.5 2.7794 112.9678 102.0322
B6.A-Chr14 f 77.5 2.7794 82.9678 72.0322
B6.A-Chr14 m 109.625 2.7794 115.0928 104.1572
B6.A-Chr15 f 75.3333 2.6205 80.4885 70.1782
B6.A-Chr15 m 108.875 2.7794 114.3428 103.4072
B6.A-Chr16 f 79.75 2.7794 85.2178 74.2822
B6.A-Chr16 m 116.625 2.7794 122.0928 111.1572
B6.A-Chr17 f 73.625 2.7794 79.0928 68.1572
B6.A-Chr17 m 102.0 2.7794 107.4678 96.5322
B6.A-Chr18 f 73.375 2.7794 78.8428 67.9072
B6.A-Chr18 m 92.875 2.7794 98.3428 87.4072
B6.A-Chr19 f 81.0 2.7794 86.4678 75.5322
B6.A-Chr19 m 110.875 2.7794 116.3428 105.4072
B6.A-Chr2 f 80.0 2.7794 85.4678 74.5322
B6.A-Chr2 m 102.375 2.7794 107.8428 96.9072
B6.A-Chr3 f 74.125 2.7794 79.5928 68.6572
B6.A-Chr3 m 98.0 2.7794 103.4678 92.5322
B6.A-Chr4 f 69.125 2.7794 74.5928 63.6572
B6.A-Chr4 m 83.375 2.7794 88.8428 77.9072
B6.A-Chr5 f 62.375 2.7794 67.8428 56.9072
B6.A-Chr5 m 88.375 2.7794 93.8428 82.9072
B6.A-Chr6 f 73.875 2.7794 79.3428 68.4072
B6.A-Chr6 m 99.5 2.7794 104.9678 94.0322
B6.A-Chr7 f 83.875 2.7794 89.3428 78.4072
B6.A-Chr7 m 104.625 2.7794 110.0928 99.1572
B6.A-Chr8 f 74.25 2.7794 79.7178 68.7822
B6.A-Chr8 m 88.6667 2.2694 93.1311 84.2022
B6.A-Chr9 f 83.0 2.7794 88.4678 77.5322
B6.A-Chr9 m 110.375 2.7794 115.8428 104.9072
B6.A-ChrX f 84.125 2.7794 89.5928 78.6572
B6.A-ChrX m 99.5 2.7794 104.9678 94.0322
B6.A-ChrY f 84.0 2.7794 89.4678 78.5322
B6.A-ChrY m 107.75 2.7794 113.2178 102.2822
C57BL/6J f 89.875 2.7794 95.3428 84.4072
C57BL/6J m 110.75 2.7794 116.2178 105.2822


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 72.5 1.9654 76.3663 68.6337
B6.A-Chr1 both 94.625 1.9654 98.4913 90.7587
B6.A-Chr10 both 85.0625 1.9654 88.9288 81.1962
B6.A-Chr11 both 84.4375 1.9654 88.3038 80.5712
B6.A-Chr12 both 88.0625 1.9654 91.9288 84.1962
B6.A-Chr13 both 97.0625 1.9654 100.9288 93.1962
B6.A-Chr14 both 93.5625 1.9654 97.4288 89.6962
B6.A-Chr15 both 92.1042 1.91 95.8616 88.3468
B6.A-Chr16 both 98.1875 1.9654 102.0538 94.3212
B6.A-Chr17 both 87.8125 1.9654 91.6788 83.9462
B6.A-Chr18 both 83.125 1.9654 86.9913 79.2587
B6.A-Chr19 both 95.9375 1.9654 99.8038 92.0712
B6.A-Chr2 both 91.1875 1.9654 95.0538 87.3212
B6.A-Chr3 both 86.0625 1.9654 89.9288 82.1962
B6.A-Chr4 both 76.25 1.9654 80.1163 72.3837
B6.A-Chr5 both 75.375 1.9654 79.2413 71.5087
B6.A-Chr6 both 86.6875 1.9654 90.5538 82.8212
B6.A-Chr7 both 94.25 1.9654 98.1163 90.3837
B6.A-Chr8 both 81.4583 1.7941 84.9878 77.9289
B6.A-Chr9 both 96.6875 1.9654 100.5538 92.8212
B6.A-ChrX both 91.8125 1.9654 95.6788 87.9462
B6.A-ChrY both 95.875 1.9654 99.7413 92.0087
C57BL/6J both 100.3125 1.9654 104.1788 96.4462




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA