Project measure / variable:   Auwerx2   chol_HFD

ID, description, units MPD:114686   chol_HFD   plasma cholesterol amount   [mmol/L]  HFD  
Data set, strains Auwerx2   inbred w/CC8   9 strains     sex: both     age: 21wks
Procedure lipid profile
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  STRAIN COMPARISON PLOT
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Auwerx2 - plasma cholesterol amount HFD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means2.8165   mmol/L 3.5172   mmol/L
Median of the strain means2.42   mmol/L 3.18   mmol/L
SD of the strain means± 1.15 ± 1.4778
Coefficient of variation (CV)0.4083 0.4202
Min–max range of strain means1.4   –   5.28   mmol/L 1.86   –   5.775   mmol/L
Mean sample size per strain4.9   mice 3.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 7.6855 7.6855 48.8983 < 0.0001
strain 7 46.618 6.6597 42.372 < 0.0001
sex:strain 7 16.8647 2.4092 15.3286 < 0.0001
Residuals 56 8.8017 0.1572


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 3.8 0.5244   5 0.23452 0.138 3.3, 4.5 0.86
129S1/SvImJ m 4.7 0.28284   2   0.2 0.0602 4.5, 4.9 0.8
A/J f 2.1 0.18257   4 0.09129 0.0869 1.9, 2.3 -0.62
A/J m 2.62 0.08367   5 0.03742 0.0319 2.5, 2.7 -0.61
C57BL/6J f 2.7333 0.15275   3 0.08819 0.0559 2.6, 2.9 -0.07
C57BL/6J m 5.775 0.84212   4 0.42106 0.1458 4.6, 6.6 1.53
CAST/EiJ f 2.42 0.13038   5 0.05831 0.0539 2.3, 2.6 -0.34
CAST/EiJ m 2.0 0.14142   2   0.1 0.0707 1.9, 2.1 -1.03
DBA/2J f 2.12 0.22804   5 0.10198 0.1076 1.9, 2.4 -0.61
DBA/2J m 3.18 0.40249   5 0.18 0.1266 2.8, 3.6 -0.23
NOD/ShiLtJ f 2.32 0.26162   10 0.08273 0.1128 2.0, 2.9 -0.43
NOD/ShiLtJ m 3.54 0.4827   5 0.21587 0.1364 3.0, 4.1 0.02
NZO/HlLtJ f 5.28 0.48683   5 0.21772 0.0922 4.6, 5.8 2.14
NZO/HlLtJ m 5.5 0.0   1   0.0 0.0 5.5, 5.5 1.34
PWK/PhJ f 3.175 0.55603   4 0.27801 0.1751 2.8, 4.0 0.31
PWK/PhJ m 2.48 0.22804   5 0.10198 0.0919 2.2, 2.7 -0.7
WSB/EiJ f 1.4 0.51962   3 0.3 0.3712 0.8, 1.7 -1.23
WSB/EiJ m 1.86 0.53666   5 0.24 0.2885 1.2, 2.4 -1.12


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 3.8 0.1772978393 4.155170251 3.444829749
129S1/SvImJ m 4.7 0.2803324982 5.2615734751 4.1384265249
A/J f 2.1 0.1982250104 2.4970924124 1.7029075876
A/J m 2.62 0.1772978393 2.975170251 2.264829749
C57BL/6J f 2.7333333333 0.2288905263 3.1918561557 2.274810511
C57BL/6J m 5.775 0.1982250104 6.1720924124 5.3779075876
CAST/EiJ f 2.42 0.1772978393 2.775170251 2.064829749
CAST/EiJ m 2.0 0.2803324982 2.5615734751 1.4384265249
DBA/2J f 2.12 0.1772978393 2.475170251 1.764829749
DBA/2J m 3.18 0.1772978393 3.535170251 2.824829749
NOD/ShiLtJ f 2.32 0.1253685044 2.5711432929 2.0688567071
NOD/ShiLtJ m 3.54 0.1772978393 3.895170251 3.184829749
PWK/PhJ f 3.175 0.1982250104 3.5720924124 2.7779075876
PWK/PhJ m 2.48 0.1772978393 2.835170251 2.124829749
WSB/EiJ f 1.4 0.2288905263 1.8585228224 0.9414771776
WSB/EiJ m 1.86 0.1772978393 2.215170251 1.504829749


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 4.25 0.1658469425 4.5822313483 3.9177686517
A/J both 2.36 0.1329733795 2.6263776882 2.0936223118
C57BL/6J both 4.2541666667 0.1513968525 4.5574510063 3.950882327
CAST/EiJ both 2.21 0.1658469425 2.5422313483 1.8777686517
DBA/2J both 2.65 0.1253685044 2.9011432929 2.3988567071
NOD/ShiLtJ both 2.93 0.1085723097 3.1474964717 2.7125035283
PWK/PhJ both 2.8275 0.1329733795 3.0938776882 2.5611223118
WSB/EiJ both 1.63 0.1447630796 1.9199952956 1.3400047044




  GWAS USING LINEAR MIXED MODELS